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anti-TLR2 antibody :: Mouse Toll-like receptor 2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS140320 anti-TLR2 antibody
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Toll-like receptor 2 (TLR2), Monoclonal Antibody

 Also Known As   

Mouse Anti Human Toll-like receptor 2

 Product Synonym Names    TLR2 Antibody; Toll-like receptor 2, Mouse Anti Human; Toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4; CD282; TLR2; TIL4
 Product Gene Name   

anti-TLR2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    246300
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 Clonality    Monoclonal
 Isotype    IgG1 heavy chain and kappa light chain
 Clone Number    P1F10AT
 Host    Mouse
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 Purity/Purification    TLR2 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
 Form/Format    1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
Sterile filtered colorless solution.
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 Immunogen    Anti-human TLR2 mAb, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human TLR2 amino acids 221-384 purified from E Coli.
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 Preparation and Storage    For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.
 Other Notes    Small volumes of anti-TLR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TLR2 antibody

   Introduction: TLR2 belongs to the Toll-like receptor (TLR) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) which are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. TLR2 is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.
 Product Categories/Family for anti-TLR2 antibody    MONOCLONAL/POLYCLONAL ANTIBODIES, MISCELLANEOUS ANTIBODIES; Monoclonal Antibodies
 Applications Tested/Suitable for anti-TLR2 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-TLR2 antibody    TLR2 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1,000. Recommended starting dilution is 1:500.
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NCBI/Uniprot data below describe general gene information for TLR2. It may not necessarily be applicable to this product.
 NCBI GI #    19718734
 NCBI GeneID    7097
 NCBI Accession #    NP_003255.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003264.3 [Other Products]
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 UniProt Secondary Accession #    O15454; Q8NI00; B3Y612; D1CS45; D1CS48; D1CS49 [Other Products]
 UniProt Related Accession #    O60603 [Other Products]
 Molecular Weight    89,838 Da
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 NCBI Official Full Name    toll-like receptor 2
 NCBI Official Synonym Full Names    toll-like receptor 2
 NCBI Official Symbol    TLR2 [Similar Products]
 NCBI Official Synonym Symbols   
TIL4; CD282
[Similar Products]
 NCBI Protein Information    toll-like receptor 2; toll/interleukin 1 receptor-like 4; toll/interleukin-1 receptor-like protein 4
 UniProt Protein Name    Toll-like receptor 2
 UniProt Synonym Protein Names   
Toll/interleukin-1 receptor-like protein 4; CD_antigen: CD282
 Protein Family    Toll-like receptor
 UniProt Gene Name    TLR2 [Similar Products]
 UniProt Synonym Gene Names    TIL4 [Similar Products]
 UniProt Entry Name    TLR2_HUMAN
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 NCBI Summary for TLR2    The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008]
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 UniProt Comments for TLR2    TLR2: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage- activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1. Interacts with CNPY3. Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues. Belongs to the Toll-like receptor family.

Protein type: Cell surface; Receptor, misc.; Apoptosis; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q32

Cellular Component: cell surface; cell projection; integral to plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane

Molecular Function: peptidoglycan binding; protein binding; transmembrane receptor activity; triacylated lipoprotein binding; protein heterodimerization activity; lipopolysaccharide receptor activity; receptor activity; pattern recognition receptor activity; diacylated lipoprotein binding

Biological Process: positive regulation of nitric oxide biosynthetic process; positive regulation of interleukin-12 production; apoptosis; response to toxin; positive regulation of leukocyte migration; microglial cell activation; positive regulation of NF-kappaB import into nucleus; leukotriene metabolic process; response to molecule of fungal origin; detection of triacylated bacterial lipoprotein; positive regulation of interleukin-18 production; signal transduction; nitric oxide metabolic process; positive regulation of interleukin-10 production; activation of NF-kappaB transcription factor; response to insulin stimulus; positive regulation of interleukin-8 production; negative regulation of cell proliferation; positive regulation of interferon-beta production; lipopolysaccharide-mediated signaling pathway; positive regulation of oligodendrocyte differentiation; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of Wnt receptor signaling pathway; positive regulation of tumor necrosis factor biosynthetic process; negative regulation of interleukin-12 production; detection of diacylated bacterial lipoprotein; cell surface pattern recognition receptor signaling pathway; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of chemokine production; positive regulation of toll-like receptor signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; induction by symbiont of defense-related host nitric oxide production; defense response to Gram-positive bacterium; negative regulation of interleukin-17 production; myelin formation in the central nervous system; response to hypoxia; toll-like receptor signaling pathway; innate immune response; immune response; positive regulation of transcription from RNA polymerase II promoter; response to progesterone stimulus; I-kappaB phosphorylation; chloramphenicol transport; positive regulation of inflammatory response; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of cytokine secretion

Disease: Leprosy, Susceptibility To, 3; Mycobacterium Tuberculosis, Susceptibility To
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 Research Articles on TLR2    1. Our results showed that the expression of TLR-2 and TLR-4 proteins in the patients group was significantly higher than that of healthy controls. TLR-2 but not TLR-4 was correlated with expanded disability status scale (EDSS).
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TLR2 antibodyPathways associated with anti-TLR2 antibody
 Reference Product  PubMed Publications
 MYD88 antibody  >1099 publications with TLR2 and MYD88
 CD14 antibody  >727 publications with TLR2 and CD14
 TLR1 antibody  >617 publications with TLR2 and TLR1
 TLR6 antibody  >469 publications with TLR2 and TLR6
 IL6 antibody  >149 publications with TLR2 and IL6
 TIRAP antibody  >115 publications with TLR2 and TIRAP
 LY96 antibody  >73 publications with TLR2 and LY96
 IRAK1 antibody  >58 publications with TLR2 and IRAK1
 TOLLIP antibody  >34 publications with TLR2 and TOLLIP
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Beta Defensins Pathway antibodies  Beta Defensins Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Defensins Pathway antibodies  Defensins Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
Diseases associated with anti-TLR2 antibodyOrgans/Tissues associated with anti-TLR2 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2104 publications with TLR2 and Inflammation
 Necrosis Antibodies  >1502 publications with TLR2 and Necrosis
 Disease Models, Animal Antibodies  >515 publications with TLR2 and Disease Models, Animal
 Respiratory Tract Diseases Antibodies  >452 publications with TLR2 and Respiratory Tract Diseases
 Lung Diseases Antibodies  >429 publications with TLR2 and Lung Diseases
 Atherosclerosis Antibodies  >201 publications with TLR2 and Atherosclerosis
 Liver Diseases Antibodies  >180 publications with TLR2 and Liver Diseases
 Asthma Antibodies  >147 publications with TLR2 and Asthma
 Heart Diseases Antibodies  >139 publications with TLR2 and Heart Diseases
 Kidney Diseases Antibodies  >115 publications with TLR2 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2582 publications with TLR2 and Blood
 Lung Antibodies  >580 publications with TLR2 and Lung
 Bone Marrow Antibodies  >461 publications with TLR2 and Bone Marrow
 Liver Antibodies  >373 publications with TLR2 and Liver
 Brain Antibodies  >308 publications with TLR2 and Brain
 Kidney Antibodies  >280 publications with TLR2 and Kidney
 Skin Antibodies  >268 publications with TLR2 and Skin
 Heart Antibodies  >175 publications with TLR2 and Heart
 Muscle Antibodies  >172 publications with TLR2 and Muscle
 Mouth Antibodies  >154 publications with TLR2 and Mouth
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