NP_003255.2
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
89,838 Da
NCBI Official Full Name
toll-like receptor 2
NCBI Official Synonym Full Names
toll-like receptor 2
NCBI Official Synonym Symbols
NCBI Protein Information
toll-like receptor 2; toll/interleukin 1 receptor-like 4; toll/interleukin-1 receptor-like protein 4
UniProt Protein Name
Toll-like receptor 2
UniProt Synonym Protein Names
Toll/interleukin-1 receptor-like protein 4; CD_antigen: CD282
UniProt Synonym Gene Names
UniProt Entry Name
TLR2_HUMAN
NCBI Summary for TLR2
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. [provided by RefSeq, Jul 2008]
UniProt Comments for TLR2
TLR2: Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage- activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. Interacts with LY96, TLR1 and TLR6 (via extracellular domain). Binds MYD88 (via TIR domain). Interacts with TICAM1. Ligand binding induces the formation of a heterodimer with TLR1. Interacts with CNPY3. Highly expressed in peripheral blood leukocytes, in particular in monocytes, in bone marrow, lymph node and in spleen. Also detected in lung and in fetal liver. Levels are low in other tissues. Belongs to the Toll-like receptor family.
Protein type: Cell surface; Receptor, misc.; Apoptosis; Motility/polarity/chemotaxis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q32
Cellular Component: cell surface; cell projection; integral to plasma membrane; cytoplasm; plasma membrane; external side of plasma membrane
Molecular Function: peptidoglycan binding; protein binding; transmembrane receptor activity; triacylated lipoprotein binding; protein heterodimerization activity; lipopolysaccharide receptor activity; receptor activity; pattern recognition receptor activity; diacylated lipoprotein binding
Biological Process: positive regulation of nitric oxide biosynthetic process; positive regulation of interleukin-12 production; apoptosis; response to toxin; positive regulation of leukocyte migration; microglial cell activation; positive regulation of NF-kappaB import into nucleus; leukotriene metabolic process; response to molecule of fungal origin; detection of triacylated bacterial lipoprotein; positive regulation of interleukin-18 production; signal transduction; nitric oxide metabolic process; positive regulation of interleukin-10 production; activation of NF-kappaB transcription factor; response to insulin stimulus; positive regulation of interleukin-8 production; negative regulation of cell proliferation; positive regulation of interferon-beta production; lipopolysaccharide-mediated signaling pathway; positive regulation of oligodendrocyte differentiation; inflammatory response; toll-like receptor 4 signaling pathway; positive regulation of Wnt receptor signaling pathway; positive regulation of tumor necrosis factor biosynthetic process; negative regulation of interleukin-12 production; detection of diacylated bacterial lipoprotein; cell surface pattern recognition receptor signaling pathway; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of chemokine production; positive regulation of toll-like receptor signaling pathway; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; induction by symbiont of defense-related host nitric oxide production; defense response to Gram-positive bacterium; negative regulation of interleukin-17 production; myelin formation in the central nervous system; response to hypoxia; toll-like receptor signaling pathway; innate immune response; immune response; positive regulation of transcription from RNA polymerase II promoter; response to progesterone stimulus; I-kappaB phosphorylation; chloramphenicol transport; positive regulation of inflammatory response; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of cytokine secretion
Disease: Leprosy, Susceptibility To, 3; Mycobacterium Tuberculosis, Susceptibility To
Research Articles on TLR2
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Products associated with anti-TLR2 antibody
Pathways associated with anti-TLR2 antibody
Diseases associated with anti-TLR2 antibody
Organs/Tissues associated with anti-TLR2 antibody
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