NP_112455.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
toll-like receptor 9
NCBI Official Synonym Full Names
toll-like receptor 9
NCBI Protein Information
toll-like receptor 9
UniProt Protein Name
Toll-like receptor 9
UniProt Synonym Protein Names
CD_antigen: CD289
UniProt Entry Name
TLR9_MOUSE
UniProt Comments for Tlr9
TLR9: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection. Interacts with MYD88 via their respective TIR domains. Interacts (via transmembrane domain) with UNC93B1. Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses. Interacts with BTK. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre- dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver. Belongs to the Toll-like receptor family. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, misc.
Cellular Component: membrane; endoplasmic reticulum; lysosome; basolateral plasma membrane; cytoplasm; apical plasma membrane; plasma membrane; integral to membrane; cytoplasmic vesicle; endosome
Molecular Function: protein binding; siRNA binding; transmembrane receptor activity; interleukin-1 receptor binding; unmethylated CpG binding
Biological Process: positive regulation of JNK activity; regulation of cytokine secretion; positive regulation of interleukin-12 production; maintenance of gastrointestinal epithelium; microglial cell activation; positive regulation of NF-kappaB import into nucleus; regulation of B cell activation; positive regulation of interferon-alpha biosynthetic process; signal transduction; positive regulation of interleukin-18 production; defense response to Gram-negative bacterium; positive regulation of interleukin-10 production; activation of NF-kappaB transcription factor; positive regulation of interleukin-8 production; response to molecule of bacterial origin; positive regulation of interferon-beta production; negative regulation of interleukin-6 production; negative regulation of interleukin-8 production; inflammatory response; defense response to virus; positive regulation of autophagy; regulation of protein amino acid phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB cascade; immune system process; response to virus; positive regulation of interleukin-6 production; positive regulation of tumor necrosis factor production; positive regulation of toll-like receptor signaling pathway; positive regulation of chemokine production; MyD88-dependent toll-like receptor signaling pathway; inhibition of NF-kappaB transcription factor; regulation of inflammatory response; positive regulation of interferon-beta biosynthetic process; negative regulation of toll-like receptor signaling pathway; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; immune response; toll-like receptor 9 signaling pathway; I-kappaB phosphorylation; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of inflammatory response; positive regulation of interferon-gamma biosynthetic process
Research Articles on Tlr9
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Products associated with anti-Tlr9 antibody
Pathways associated with anti-Tlr9 antibody
Diseases associated with anti-Tlr9 antibody
Organs/Tissues associated with anti-Tlr9 antibody
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