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anti-TMEFF2 antibody :: Mouse Tomoregulin-2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS140322 anti-TMEFF2 antibody
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tomoregulin-2 (TMEFF2), Monoclonal Antibody

 Also Known As   

Mouse Anti Human Tomoregulin-2

 Product Synonym Names    TMEFF2 Antibody; Tomoregulin-2, Mouse Anti Human; TMEFF2; Tomoregulin-2; Transmembrane protein with EGF-like and two follistatin-like domains; Hyperplastic polyposis protein 1; HPP1; TENB2; TPEF; TR; CT120.2
 Product Gene Name   

anti-TMEFF2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605734
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 Clonality    Monoclonal
 Isotype    IgG2b heavy chain and kappa light chain
 Clone Number    PJ4B6AT
 Host    Mouse
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 Purity/Purification    TMEFF2 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
 Form/Format    1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
Sterile filtered colorless solution.
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 Immunogen    Anti-human TMEFF2 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human TMEFF2 amino acids 41-150 purified from E Coli.
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 Preparation and Storage    For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.
 Other Notes    Small volumes of anti-TMEFF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TMEFF2 antibody

   Introduction: TMEFF2 is a gene encoding a plasma membrane protein with two follistatin-like domains and one epidermal growth factorlike domain. TMEFF2 has limited normal tissue distribution and is highly overexpressed in prostate cancer. The shedded form of TMEFF2 up-regulates cancer cell proliferation, most likely by promoting ERK1/2 phosphorylation. TMEFF2 is down-regulated in tumor cell lines in response to a high level of methylation in the 5'' region.
 Product Categories/Family for anti-TMEFF2 antibody    MONOCLONAL/POLYCLONAL ANTIBODIES, MISCELLANEOUS ANTIBODIES; Monoclonal Antibodies
 Applications Tested/Suitable for anti-TMEFF2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-TMEFF2 antibody    TMEFF2 antibody has been tested by ELISA, Western blot and immunohistochemistry analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot is 1:1,000~1:2,000 and immunohistochemistry analysis is 1:50~100. Recommended starting dilution for Western blot is 1:1,000 and Immunohistochemistry is 1:50.
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NCBI/Uniprot data below describe general gene information for TMEFF2. It may not necessarily be applicable to this product.
 NCBI GI #    762205501
 NCBI GeneID    23671
 NCBI Accession #    NP_001292074.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001305145.1 [Other Products]
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 UniProt Secondary Accession #    Q2FA44; Q4ZFW4; Q53H90; Q53RE1; Q8N2R5; Q9NR15; Q9NSS5; Q9P2Y9; Q9UK65 [Other Products]
 UniProt Related Accession #    Q9UIK5 [Other Products]
 Molecular Weight    19,472 Da
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 NCBI Official Full Name    tomoregulin-2 isoform 3
 NCBI Official Synonym Full Names    transmembrane protein with EGF-like and two follistatin-like domains 2
 NCBI Official Symbol    TMEFF2 [Similar Products]
 NCBI Official Synonym Symbols   
TR; HPP1; TPEF; TR-2; TENB2; CT120.2
[Similar Products]
 NCBI Protein Information    tomoregulin-2; cancer/testis antigen family 120, member 2; hyperplastic polyposis protein 1; transmembrane protein TENB2
 UniProt Protein Name    Tomoregulin-2
 UniProt Synonym Protein Names   
Hyperplastic polyposis protein 1; Transmembrane protein with EGF-like and two follistatin-like domains
 Protein Family    Tomoregulin
 UniProt Gene Name    TMEFF2 [Similar Products]
 UniProt Synonym Gene Names    HPP1; TENB2; TPEF; TR-2 [Similar Products]
 UniProt Entry Name    TEFF2_HUMAN
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 NCBI Summary for TMEFF2    This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
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 UniProt Comments for TMEFF2    TMEFF2: may be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation. A member of the Cancer-Testis Antigen (CTA) superfamily. CTAs may play roles in embryonal development and tumor transformation or aspects of tumor progression. CTAs were once thought to be silenced in most normal adult tissues, with limited expression in fetal, placental, testis, and ovarian cells. These proteins are now known to be aberrantly expressed in various cancers and many are capable of eliciting humoral and cellular immune responses. Highly expressed in adult and fetal brain, spinal cord and prostate. Expressed in all brain regions except the pituitary gland, with highest levels in amygdala and corpus callosum. Expressed in the pericryptal myofibroblasts and other stromal cells of normal colonic mucosa. Expressed in prostate carcinoma. Down-regulated in colorectal cancer. Present in Alzheimer disease plaques. Down-regulated in tumor cell lines in response to a high level of methylation in the 5' region. The CpG island methylation correlates with TMEFF2 silencing in tumor cell lines. Belongs to the tomoregulin family. Three isoforms of the human protein are produced by alternative splicing. Isoform three is expressed weakly in testis and at high levels in normal and cancerous prostate. Note: This description may include information from RefSeq and UniProtKB

Protein type: Membrane protein, integral; Cancer Testis Antigen (CTA); Cell surface

Chromosomal Location of Human Ortholog: 2q32.3

Cellular Component: integral to membrane; extracellular region
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 Research Articles on TMEFF2    1. TMEFF2 and SARDH cooperate to modulate one-carbon metabolism and invasion of prostate cancer cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-TMEFF2 antibodyDiseases associated with anti-TMEFF2 antibody
 Products by Pathway  Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Repression Pathway antibodies  Validated Targets Of C-MYC Transcriptional Repression Pathway Diagram
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >14 publications with TMEFF2 and Adenocarcinoma
 Prostatic Neoplasms Antibodies  >14 publications with TMEFF2 and Prostatic Neoplasms
 Lung Neoplasms Antibodies  >8 publications with TMEFF2 and Lung Neoplasms
 Lung Diseases Antibodies  >6 publications with TMEFF2 and Lung Diseases
 Respiratory Tract Diseases Antibodies  >6 publications with TMEFF2 and Respiratory Tract Diseases
 Hyperplasia Antibodies  >6 publications with TMEFF2 and Hyperplasia
 Urinary Bladder Neoplasms Antibodies  >4 publications with TMEFF2 and Urinary Bladder Neoplasms
 Brain Diseases Antibodies  >3 publications with TMEFF2 and Brain Diseases
 Nervous System Diseases Antibodies  >3 publications with TMEFF2 and Nervous System Diseases
 Central Nervous System Diseases Antibodies  >3 publications with TMEFF2 and Central Nervous System Diseases
Organs/Tissues associated with anti-TMEFF2 antibody
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >24 publications with TMEFF2 and Prostate
 Brain Antibodies  >17 publications with TMEFF2 and Brain
 Lung Antibodies  >9 publications with TMEFF2 and Lung
 Nerve Antibodies  >7 publications with TMEFF2 and Nerve
 Intestine Antibodies  >3 publications with TMEFF2 and Intestine
 Embryonic Tissue Antibodies  >3 publications with TMEFF2 and Embryonic Tissue
 Bone Antibodies  >2 publications with TMEFF2 and Bone
 Connective Tissue Antibodies  >1 publications with TMEFF2 and Connective Tissue
 Eye Antibodies  >1 publications with TMEFF2 and Eye
 Kidney Antibodies  >1 publications with TMEFF2 and Kidney
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