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anti-TOP2B antibody :: Mouse anti-Mouse, Rat Topoisomerase II Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS530015 anti-TOP2B antibody
Unit / Price
0.1 mg  /  $670 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Topoisomerase II (TOP2B), Monoclonal Antibody

 Also Known As   

Topoisomerase II antibody

 Product Synonym Names    Monoclonal Topoisomerase II; Anti-Topoisomerase II; Anti Topoisomerase II; Topoisomerase II alpha; Topoisomerase II; Topoisomerase II beta
 Product Gene Name   

anti-TOP2B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    126431
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    AK5
 Host    Mouse
 Species Reactivity    Mouse, Rat
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 Specificity    Human
 Purity/Purification    Topoisomerase II antibody was purified by affinity chromatography.
 Form/Format    PBS, pH7.2, with 50% glycerol.
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 Biological Significance    Type II topoisomerases cut both strands of the DNA helix simultaneously in order to unwind it. The energy required for this is the hydrolysis of ATP, unlike type I topoisomerase, which is thermodynamically favored. In this process, these enzymes change the linking number of circular DNA by +/-2.
 Immunogen    Topoisomerase II antibody was raised in mouse using recombinant human DNA-topoisomerase IIa (N-terminal fragment) as the immunogen.
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 Preparation and Storage    Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
 Other Notes    Small volumes of anti-TOP2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TOP2B antibody

   Mouse monoclonal Topoisomerase II antibody
 Product Categories/Family for anti-TOP2B antibody    DNA & RNA
 Applications Tested/Suitable for anti-TOP2B antibody   

Western Blot (WB)

 Application Notes for anti-TOP2B antibody    WB: 5-10 ug/ml
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NCBI/Uniprot data below describe general gene information for TOP2B. It may not necessarily be applicable to this product.
 NCBI GI #    339810
 NCBI Accession #    AAA61210.1 [Other Products]
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 UniProt Secondary Accession #    Q13600; Q9UMG8; Q9UQP8 [Other Products]
 Molecular Weight    182,663 Da [Similar Products]
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 NCBI Official Full Name    topoisomerase II, partial
 UniProt Protein Name    DNA topoisomerase 2-beta
 UniProt Synonym Protein Names   
DNA topoisomerase II, beta isozyme
 Protein Family    DNA topoisomerase
 UniProt Gene Name    TOP2B [Similar Products]
 UniProt Entry Name    TOP2B_HUMAN
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 UniProt Comments for TOP2B    TOP2B: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene. Belongs to the type II topoisomerase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Topoisomerase; DNA-binding; Motility/polarity/chemotaxis; EC 5.99.1.3; Nucleolus; Cell development/differentiation

Chromosomal Location of Human Ortholog: 3p24

Cellular Component: nucleoplasm; heterochromatin; DNA topoisomerase complex (ATP-hydrolyzing); cytoplasm; nucleolus; nucleus; cytosol

Molecular Function: protein C-terminus binding; DNA topoisomerase (ATP-hydrolyzing) activity; enzyme binding; protein kinase C binding; protein heterodimerization activity; metal ion binding; histone deacetylase binding; chromatin binding; DNA bending activity; ATP binding

Biological Process: DNA unwinding during replication; mitotic recombination; DNA topological change; axonogenesis; forebrain development; neuron migration; sister chromatid segregation; resolution of meiotic joint molecules as recombinants
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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