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anti-TGFB1I1 antibody :: Mouse anti-Bovine Transforming Growth Factor, beta Binding Protein 2, latent Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS605150 anti-TGFB1I1 antibody
Unit / Price
0.2 mL  /  $540 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Transforming Growth Factor, beta Binding Protein 2, latent (TGFB1I1), Monoclonal Antibody

 Also Known As   

Transforming Growth Factor, beta Binding Protein 2, NT, latent (LTBP-2)

 Product Synonym Names    Anti -Transforming Growth Factor, beta Binding Protein 2, NT, latent (LTBP-2)
 Product Gene Name   

anti-TGFB1I1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 16; NC_000016.9 (31483476..31489281). Location: 16p11.2
 OMIM    602353
 3D Structure    ModBase 3D Structure for O43294
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    9G2
 Host    Mouse
 Species Reactivity    Bovine
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 Specificity    Recognizes bovine LTBP-2.
 Purity/Purification    Ascites
Ascites
 Form/Format    Supplied as a lyophilized powder. Reconstitute with 200ul sterile ddH2O, 0.01% Thimerosal.
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 Immunogen    Amino-terminal third of bovine LTBP-2.
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O, 0.01% Thimerosal. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
 Other Notes    Small volumes of anti-TGFB1I1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TGFB1I1 antibody

   Elastic fibers play the principal roles in providing elasticity and integrity to various types of human organs, such as the arteries, lung, and skin. However, the molecular mechanism of elastic fiber assembly that leads to deposition and crosslinking of elastin along microfibrils remains largely unknown. It has been previously shown that developing arteries and neural crest EGF-like protein (DANCE) (also designated fibulin-5) is essential for elastogenesis by studying DANCE-deficient mice. It is reported that the identification of latent transforming growth factor--binding protein 2 (LTBP-2), an elastic fiber-associating protein whose function in elastogenesis is not clear, as a DANCE-binding protein. Elastogenesis assays using human skin fibroblasts reveal that fibrillar deposition of DANCE and elastin is largely dependent on fibrillin-1 microfibrils. However, downregulation of LTBP-2 induces fibrillin-1-independent fibrillar deposition of DANCE and elastin. Moreover, recombinant LTBP-2 promotes deposition of DANCE onto fibrillin-1 microfibrils. These results suggest a novel regulatory mechanism of elastic fiber assembly in which LTBP-2 regulates targeting of DANCE on suitable microfibrils to form elastic fibers.
 Product Categories/Family for anti-TGFB1I1 antibody    Antibodies; Abs to Growth Factors, Cytokines
 Applications Tested/Suitable for anti-TGFB1I1 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

 Application Notes for anti-TGFB1I1 antibody    Suitable for Western Blot, ELISA, Immunoprecipitation and Immunohistochemistry.
Dilution: ELISA: 1:1000 -1:2000
Western Blot: 1:200 -1:500
Immunoprecipitation: 1:100 -1:200
Immunohistochemistry: 1:50 -1:100
In many cases, antigenicity of elastic fiber components can be enhanced by treating with 6M guanidine HCl, 50mM dithiothreitol, 20mM Tris pH 8.0 for 15 minutes. After washing with 20mM Tris pH 8.0, the slides are treated with 100mM iodoacetamide in the dark for 15 minutes, washed and stained using normal protocols.
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NCBI/Uniprot data below describe general gene information for TGFB1I1. It may not necessarily be applicable to this product.
 NCBI GI #    150416155
 NCBI GeneID    7041
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 UniProt Primary Accession #    O43294 [Other Products]
 UniProt Secondary Accession #    Q9BPW3; Q9Y2V5; B2R8D5 [Other Products]
 UniProt Related Accession #    O43294 [Other Products]
 Molecular Weight    49,814 Da [Similar Products]
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 NCBI Official Full Name    Transforming growth factor beta-1-induced transcript 1 protein
 NCBI Official Synonym Full Names    transforming growth factor beta 1 induced transcript 1
 NCBI Official Symbol    TGFB1I1 [Similar Products]
 NCBI Official Synonym Symbols   
HIC5; ARA55; HIC-5; TSC-5
[Similar Products]
 NCBI Protein Information    transforming growth factor beta-1-induced transcript 1 protein; OTTHUMP00000163301; OTTHUMP00000197012; androgen receptor coactivator ARA55; hydrogen peroxide-inducible clone 5 protein; androgen receptor coactivator 55 kDa protein; androgen receptor-associated protein of 55 kDa
 UniProt Protein Name    Transforming growth factor beta-1-induced transcript 1 protein
 UniProt Synonym Protein Names   
Androgen receptor coactivator 55 kDa protein; Androgen receptor-associated protein of 55 kDa; Hydrogen peroxide-inducible clone 5 protein
 Protein Family    Transforming growth factor beta-1-induced transcript 1 protein
 UniProt Gene Name    TGFB1I1 [Similar Products]
 UniProt Synonym Gene Names    ARA55 [Similar Products]
 UniProt Entry Name    TGFI1_HUMAN
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 NCBI Summary for TGFB1I1    This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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 UniProt Comments for TGFB1I1    Hic-5: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA- binding activity. Homooligomer. Interacts with CRIP2, HSPB1, ILK, LIMS1, LIMS2, NCK2, NUDT16L1, PAK, PPARG, PTPN12, TCF3, TCF7L2 and VCL. Forms a complex with GIT1 and ARHGEF7. Interacts with AR/androgen receptor in a ligand-dependent manner. Interacts with CSK, LYN, MAPK15, NR3C1, PPARG, PTK2/FAK1, PTK2B/PYK2, SLC6A3, SLC6A4, SMAD3, SRC and talin. Up-regulated by TNF and hydrogen peroxide. Expressed in platelets, smooth muscle and prostate stromal cells. Belongs to the paxillin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: extracellular matrix; focal adhesion; nuclear matrix; cytoskeleton; cytoplasm; intracellular

Molecular Function: protein binding; Roundabout binding; androgen receptor binding; zinc ion binding; transcription coactivator activity

Biological Process: transcription from RNA polymerase II promoter; cell fate commitment; Wnt receptor signaling pathway; positive regulation of transcription, DNA-dependent; positive regulation of transforming growth factor beta receptor signaling pathway; negative regulation of fat cell differentiation; ubiquitin-dependent SMAD protein catabolic process; negative regulation of cell proliferation; morphogenesis of embryonic epithelium; epithelial cell differentiation; response to heat; androgen receptor signaling pathway; negative regulation of transforming growth factor beta receptor signaling pathway; cell adhesion
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 Research Articles on TGFB1I1    1. Hic-5 is essential for adhesion formation in 3D extracellular matrices.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TGFB1I1 antibodyPathways associated with anti-TGFB1I1 antibody
 Reference Product  PubMed Publications
 PTK2 antibody  >10 publications with TGFB1I1 and PTK2
 PTK2B antibody  >4 publications with TGFB1I1 and PTK2B
 PTPN12 antibody  >3 publications with TGFB1I1 and PTPN12
 SMAD3 antibody  >3 publications with TGFB1I1 and SMAD3
 Products by Pathway  Pathway Diagram
 Androgen Receptor Signaling Pathway antibodies  Androgen Receptor Signaling Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 Monoamine Transport Pathway antibodies  Monoamine Transport Pathway Diagram
Diseases associated with anti-TGFB1I1 antibodyOrgans/Tissues associated with anti-TGFB1I1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >24 publications with TGFB1I1 and Neoplasms
 Prostatic Neoplasms Antibodies  >17 publications with TGFB1I1 and Prostatic Neoplasms
 Cell Transformation, Neoplastic Antibodies  >4 publications with TGFB1I1 and Cell Transformation, Neoplastic
 Carcinoma Antibodies  >4 publications with TGFB1I1 and Carcinoma
 Fibrosis Antibodies  >4 publications with TGFB1I1 and Fibrosis
 Hypertrophy Antibodies  >2 publications with TGFB1I1 and Hypertrophy
 Pain Antibodies  >2 publications with TGFB1I1 and Pain
 Kidney Neoplasms Antibodies  >2 publications with TGFB1I1 and Kidney Neoplasms
 Colorectal Neoplasms Antibodies  >2 publications with TGFB1I1 and Colorectal Neoplasms
 Neurodegenerative Diseases Antibodies  >2 publications with TGFB1I1 and Neurodegenerative Diseases
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >22 publications with TGFB1I1 and Prostate
 Muscle Antibodies  >16 publications with TGFB1I1 and Muscle
 Vascular Antibodies  >10 publications with TGFB1I1 and Vascular
 Embryonic Tissue Antibodies  >6 publications with TGFB1I1 and Embryonic Tissue
 Kidney Antibodies  >5 publications with TGFB1I1 and Kidney
 Connective Tissue Antibodies  >4 publications with TGFB1I1 and Connective Tissue
 Skin Antibodies  >4 publications with TGFB1I1 and Skin
 Lung Antibodies  >3 publications with TGFB1I1 and Lung
 Heart Antibodies  >3 publications with TGFB1I1 and Heart
 Bone Antibodies  >3 publications with TGFB1I1 and Bone
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