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anti-TREM2 antibody :: Mouse Triggering receptor expressed on myeloid cells 2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS140325 anti-TREM2 antibody
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
0.1 mg  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Triggering receptor expressed on myeloid cells 2 (TREM2), Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse Anti Human Triggering receptor expressed on myeloid cells 2

 Product Synonym Names    TREM2 Antibody; Triggering receptor expressed on myeloid cells 2, Mouse Anti Human; Triggering receptor expressed on myeloid cells 2; Triggering receptor expressed on monocytes 2; TREM-2; TREM2; Trem2a; Trem2b; Trem2c
 Product Gene Name   

anti-TREM2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    221770
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 Clonality    Monoclonal
 Isotype    IgG3 heavy chain and kappa light chain
 Clone Number    P2B5AT
 Host    Mouse
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 Purity/Purification    TREM2 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
 Form/Format    1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
 Concentration    1mg/ml (lot specific)
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 Immunogen    Anti-human TREM2 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human TREM2 amino acids 19-161 purified from E Coli.
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 Preparation and Storage    For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.
12 months at -20 degree C. 1 month at 4 degree C.
 Other Notes    Small volumes of anti-TREM2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TREM2 antibody

   Introduction: TREM2 is a membrane protein that forms a receptor signaling complex with TYROBP. TREM2 may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in the TREM2 gene are a source of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL).
 Product Categories/Family for anti-TREM2 antibody    MONOCLONAL/POLYCLONAL ANTIBODIES, MISCELLANEOUS ANTIBODIES; Monoclonal Antibodies
 Applications Tested/Suitable for anti-TREM2 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-TREM2 antibody    TREM2 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1,000.Recommended starting dilution is 1:500.
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NCBI/Uniprot data below describe general gene information for TREM2. It may not necessarily be applicable to this product.
 NCBI GI #    9507203
 NCBI GeneID    54209
 NCBI Accession #    NP_061838.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_018965.3 [Other Products]
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 UniProt Secondary Accession #    Q8N5H8; Q8WYN6 [Other Products]
 UniProt Related Accession #    Q9NZC2 [Other Products]
 Molecular Weight    24,669 Da
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 NCBI Official Full Name    triggering receptor expressed on myeloid cells 2 isoform 1
 NCBI Official Synonym Full Names    triggering receptor expressed on myeloid cells 2
 NCBI Official Symbol    TREM2 [Similar Products]
 NCBI Official Synonym Symbols   
TREM-2; Trem2a; Trem2b; Trem2c
[Similar Products]
 NCBI Protein Information    triggering receptor expressed on myeloid cells 2; triggering receptor expressed on monocytes 2; triggering receptor expressed on myeloid cells 2a
 UniProt Protein Name    Triggering receptor expressed on myeloid cells 2
 UniProt Synonym Protein Names   
Triggering receptor expressed on monocytes 2
 Protein Family    Triggering receptor expressed on myeloid cells
 UniProt Gene Name    TREM2 [Similar Products]
 UniProt Synonym Gene Names    TREM-2 [Similar Products]
 UniProt Entry Name    TREM2_HUMAN
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 NCBI Summary for TREM2    This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
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 UniProt Comments for TREM2    TREM2: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. Defects in TREM2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also known as presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: intracellular membrane-bound organelle; extracellular region; plasma membrane; integral to membrane

Molecular Function: peptidoglycan binding; lipopolysaccharide binding; receptor activity

Biological Process: axon guidance; positive regulation of peptidyl-tyrosine phosphorylation; detection of lipopolysaccharide; detection of peptidoglycan; innate immune response; positive regulation of calcium-mediated signaling; humoral immune response; positive regulation of antigen processing and presentation of peptide antigen via MHC class II

Disease: Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy
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 Research Articles on TREM2    1. TREM2 heterozygous mutation si a strong genetic risk factor of frontotemporal dementia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TREM2 antibodyPathways associated with anti-TREM2 antibody
 Reference Product  PubMed Publications
 TYROBP antibody  >50 publications with TREM2 and TYROBP
 SYK antibody  >8 publications with TREM2 and SYK
 PLXNA1 antibody  >2 publications with TREM2 and PLXNA1
 VAV3 antibody  >1 publications with TREM2 and VAV3
 SEMA6D antibody  >1 publications with TREM2 and SEMA6D
 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Osteoclast Differentiation Pathway antibodies  Osteoclast Differentiation Pathway Diagram
 Other Semaphorin Interactions Pathway antibodies  Other Semaphorin Interactions Pathway Diagram
 Semaphorin Interactions Pathway antibodies  Semaphorin Interactions Pathway Diagram
Diseases associated with anti-TREM2 antibodyOrgans/Tissues associated with anti-TREM2 antibody
 Disease Name  Pubmed Publications
 Dementia Antibodies  >91 publications with TREM2 and Dementia
 Nervous System Diseases Antibodies  >83 publications with TREM2 and Nervous System Diseases
 Alzheimer Disease Antibodies  >63 publications with TREM2 and Alzheimer Disease
 Inflammation Antibodies  >55 publications with TREM2 and Inflammation
 Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy Antibodies  >23 publications with TREM2 and Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
 Disease Models, Animal Antibodies  >14 publications with TREM2 and Disease Models, Animal
 Necrosis Antibodies  >12 publications with TREM2 and Necrosis
 Skin Diseases Antibodies  >10 publications with TREM2 and Skin Diseases
 Lung Diseases Antibodies  >8 publications with TREM2 and Lung Diseases
 Memory Disorders Antibodies  >4 publications with TREM2 and Memory Disorders
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >77 publications with TREM2 and Brain
 Lung Antibodies  >12 publications with TREM2 and Lung
 Eye Antibodies  >2 publications with TREM2 and Eye
 Ovary Antibodies  >2 publications with TREM2 and Ovary
 Kidney Antibodies  >1 publications with TREM2 and Kidney
 Adipose Tissue Antibodies  >1 publications with TREM2 and Adipose Tissue
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