Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow TNNI3 rightarrow Monoclonal TNNI3  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • PROTEIN G BINDING ANTIBODY Purification Kit
 • Anti-Oxidized Low Density Lipoprotein Antibody (OLAb) ELISA Kit
 • soluble Cluster of differentiation 40 ligand (Scd40l) ELISA Kit
 • Histone-binding protein RBBP4 (rbbp4) Recombinant Protein
 • Anti-Thrombopoietin Receptor Antibody (anti-TPO R Ab) ELISA Kit
 • Klotho ELISA Kit
 • Glutamate [NMDA] Receptor Subunit Epsilon-3 (GRIN2C) ELISA Kit
 • Jacalin Protein
 • Vitamin K-dependent protein C (PROC) Recombinant Protein
 • Corticosterone ELISA Kit
 • HVEM-TR2 (TNFRSF14) Antibody
 • dopamine, DA ELISA Kit
 • Anti-Glycoprotein 210 Antibody (AGPA) ELISA Kit
 • Golgin A4 (GOLGA4) Antibody
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-TNNI3 antibody :: Mouse anti-Human Troponin I Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS531901 anti-TNNI3 antibody
Unit / Price
1 mg  /  $575 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Troponin I (TNNI3), Monoclonal Antibody

 Also Known As   

Troponin I antibody (Cardiac)

 Product Synonym Names    Monoclonal Troponin I (Cardiac); Anti-Troponin I (Cardiac)
 Product Gene Name   

anti-TNNI3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    115210
 3D Structure    ModBase 3D Structure for P19429
Section Bar
 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    M9011522
 Host    Mouse
 Species Reactivity    Human
Section Bar
 Purity/Purification    Troponin I antibody (Cardiac) was purified by chromatography on protein A Sepharose.
 Form/Format    Protein A purified IgG supplied in PBS, pH 7.4, 0.1 % NaN3.
Section Bar
 Biological Significance    Human troponin I is presented in cardiac muscle tissue by a single isoform with molecular weight 23876 Da and it consists of 209 amino acid residues. cTnI molecule contains two serines in the 22 and 23 positions. Both amino acid residues can be phosphorylated in vivo by protein kinase A, so four forms of protein ? one dephospho, two monophospho and one bisphospho ? can coexist in the cell.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Immunogen    Troponin I antibody (cardiac) was raised in mouse using animo acid residues 169-178 of cTnI as the immunogen.
Section Bar
 Preparation and Storage    Store at 4 degree C.
 Other Notes    Small volumes of anti-TNNI3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for anti-TNNI3 antibody

   Mouse monoclonal Troponin I antibody (Cardiac)
 Product Categories/Family for anti-TNNI3 antibody    Cardiac Markers
 Applications Tested/Suitable for anti-TNNI3 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for TNNI3. It may not necessarily be applicable to this product.
 NCBI GI #    151101270
 NCBI GeneID    7137
 NCBI Accession #    NP_000354.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_000363.4 [Other Products]
Section Bar
 UniProt Primary Accession #    P19429 [Other Products]
 UniProt Related Accession #    P19429 [Other Products]
 Molecular Weight    24,008 Da [Similar Products]
Table BarTOPTable Bar
 NCBI Official Full Name    troponin I, cardiac muscle
 NCBI Official Synonym Full Names    troponin I type 3 (cardiac)
 NCBI Official Symbol    TNNI3 [Similar Products]
 NCBI Official Synonym Symbols   
CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF
[Similar Products]
 NCBI Protein Information    troponin I, cardiac muscle
 UniProt Protein Name    Troponin I, cardiac muscle
 UniProt Synonym Protein Names   
Cardiac troponin I
 Protein Family    Troponin
 UniProt Gene Name    TNNI3 [Similar Products]
 UniProt Synonym Gene Names    TNNC1 [Similar Products]
 UniProt Entry Name    TNNI3_HUMAN
Section Bar
 NCBI Summary for TNNI3    Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008]
Section Bar
 UniProt Comments for TNNI3    TNNI3: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1. Belongs to the troponin I family.

Protein type: Motility/polarity/chemotaxis; Actin-binding; Motor

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: sarcomere; troponin complex; cytosol

Molecular Function: troponin T binding; protein domain specific binding; troponin C binding; protein binding; metal ion binding; calcium channel inhibitor activity; actin binding; protein kinase binding; calcium-dependent protein binding

Biological Process: cellular calcium ion homeostasis; regulation of smooth muscle contraction; heart contraction; heart development; regulation of systemic arterial blood pressure by ischemic conditions; ventricular cardiac muscle morphogenesis; vasculogenesis; negative regulation of ATPase activity; muscle filament sliding; cardiac muscle contraction

Disease: Cardiomyopathy, Dilated, 1ff; Cardiomyopathy, Familial Restrictive, 1; Cardiomyopathy, Familial Hypertrophic, 7; Cardiomyopathy, Dilated, 2a
Table BarTOPTable Bar
 Research Articles on TNNI3    1. the effect of the S23D/S24D troponin I mutation on cardiac troponin structural dynamics
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-TNNI3 antibodyPathways associated with anti-TNNI3 antibody
 Reference Product  PubMed Publications
 TNNT2 antibody  >59 publications with TNNI3 and TNNT2
 TPM1 antibody  >35 publications with TNNI3 and TPM1
 TPM3 antibody  >18 publications with TNNI3 and TPM3
 MYH6 antibody  >13 publications with TNNI3 and MYH6
 TNNC1 antibody  >13 publications with TNNI3 and TNNC1
 TNNT3 antibody  >3 publications with TNNI3 and TNNT3
 TNNT1 antibody  >2 publications with TNNI3 and TNNT1
 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
Diseases associated with anti-TNNI3 antibodyOrgans/Tissues associated with anti-TNNI3 antibody
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >79 publications with TNNI3 and Heart Diseases
 Cardiomyopathies Antibodies  >69 publications with TNNI3 and Cardiomyopathies
 Cardiomyopathy, Hypertrophic, Familial Antibodies  >27 publications with TNNI3 and Cardiomyopathy, Hypertrophic, Familial
 Cardiomyopathy, Dilated Antibodies  >20 publications with TNNI3 and Cardiomyopathy, Dilated
 CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 7 Antibodies  >9 publications with TNNI3 and CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 7
 Cardiomyopathy, Restrictive Antibodies  >9 publications with TNNI3 and Cardiomyopathy, Restrictive
 Nervous System Diseases Antibodies  >5 publications with TNNI3 and Nervous System Diseases
 Fibrosis Antibodies  >5 publications with TNNI3 and Fibrosis
 Hypertension Antibodies  >4 publications with TNNI3 and Hypertension
 Cardiomyopathy, Familial Restrictive, 1 Antibodies  >3 publications with TNNI3 and Cardiomyopathy, Familial Restrictive, 1
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >66 publications with TNNI3 and Heart
 Embryonic Tissue Antibodies  >4 publications with TNNI3 and Embryonic Tissue
 Lung Antibodies  >2 publications with TNNI3 and Lung
 Skin Antibodies  >1 publications with TNNI3 and Skin
 Uterus Antibodies  >1 publications with TNNI3 and Uterus
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions