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anti-Tnnt2 antibody :: Mouse anti-Human Troponin T Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS530117 anti-Tnnt2 antibody
Unit / Price
1 mg  /  $520 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Troponin T (Tnnt2), Monoclonal Antibody

 Also Known As   

Troponin T antibody (Cardiac)

 Product Synonym Names    Monoclonal Troponin T (Cardiac); Anti-Troponin T (Cardiac)
 Product Gene Name   

anti-Tnnt2 antibody

[Similar Products]
 Matching Pairs    Antibody: Troponin T Clone #M401134 (MBS530117)
Antigen: Troponin T (MBS537207)
Comments: >98% pure by SDS-PAGE
 Matching Pairs    Capture Antibody: Troponin T Clone #M322512 (MBS531260)
Detection Antibody: Troponin T Clone #M401134 (MBS530117)
Comments: Quantitative sandwich immunoassay
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P50753
 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    M401134
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    Troponin T antibody (Cardiac) was purified by chromatography on protein A Sepharose.
 Form/Format    IgG purified by DEAE and supplied in PBS, pH 7.4, with 0.1 % NaN3.
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 Biological Significance    Troponin T is a part of the troponin complex. It binds to tropomyosin, interlocking them to form a troponin-tropomyosin complex. Troponin T binds to tropomyosin and helps position it on actin. It also modulates contraction of striated muscle. The tissue specific subtypes are slow skeletal troponin T1, cardiac troponin T2, and fast skeletal troponin T3.
 Biohazard Information    This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
 Immunogen    Troponin T antibody (cardiac) was raised in mouse using free human cTnT as the immunogen.
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 Preparation and Storage    Store at 4 degree C.
 Other Notes    Small volumes of anti-Tnnt2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Tnnt2 antibody

   Mouse monoclonal Troponin T antibody (Cardiac)
 Product Categories/Family for anti-Tnnt2 antibody    Cardiac Markers
 Applications Tested/Suitable for anti-Tnnt2 antibody   

ELISA (EIA)

 Application Notes for anti-Tnnt2 antibody    MBS530117 can be used as the detection antibody along with MBS531260 as the coating antibody
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NCBI/Uniprot data below describe general gene information for Tnnt2. It may not necessarily be applicable to this product.
 NCBI GI #    207522
 NCBI GeneID    24837
 NCBI Accession #    AAA42297.1 [Other Products]
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 UniProt Primary Accession #    P50753 [Other Products]
 UniProt Related Accession #    P50753 [Other Products]
 Molecular Weight    34,452 Da [Similar Products]
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 NCBI Official Full Name    troponin T
 NCBI Official Synonym Full Names    troponin T type 2 (cardiac)
 NCBI Official Symbol    Tnnt2 [Similar Products]
 NCBI Official Synonym Symbols   
Ctt; CTTG; Tnnt3; RATCTTG
[Similar Products]
 NCBI Protein Information    troponin T, cardiac muscle
 UniProt Protein Name    Troponin T, cardiac muscle
 UniProt Synonym Protein Names   
Cardiac muscle troponin T; cTnT
 Protein Family    Troponin
 UniProt Gene Name    Tnnt2 [Similar Products]
 UniProt Synonym Gene Names    TnTc; cTnT [Similar Products]
 UniProt Entry Name    TNNT2_RAT
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 NCBI Summary for Tnnt2    tropomyosin-binding subunit of troponin; confers calcium-sensitivy to actinomysin ATPase activity in striated muscle [RGD, Feb 2006]
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 UniProt Comments for Tnnt2    TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Motor

Cellular Component: sarcomere; troponin complex; myofibril; cytoplasm; striated muscle thin filament

Molecular Function: protein binding, bridging; troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; actin binding; tropomyosin binding

Biological Process: actin crosslink formation; metabolic process; protein heterooligomerization; atrial cardiac muscle morphogenesis; regulation of muscle contraction; heart development; regulation of muscle filament sliding speed; sarcomere organization; regulation of heart contraction; muscle filament sliding; muscle contraction; positive regulation of ATPase activity; ventricular cardiac muscle morphogenesis; response to calcium ion; negative regulation of ATPase activity; cardiac muscle contraction
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 Research Articles on Tnnt2    1. Replacement of the functionally corresponding N-terminal end portion of rat fast skeletal cardiac muscle (RfsTnT) into cardiac muscle troponin T (RcTnT), the observed functional differences associate with a sequence variation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-Tnnt2 antibodyPathways associated with anti-Tnnt2 antibody
 Reference Product  PubMed Publications
 Tnni3 antibody  >59 publications with Tnnt2 and Tnni3
 Tpm1 antibody  >39 publications with Tnnt2 and Tpm1
 Tpm3 antibody  >25 publications with Tnnt2 and Tpm3
 Tnnc1 antibody  >14 publications with Tnnt2 and Tnnc1
 Tnnt1 antibody  >2 publications with Tnnt2 and Tnnt1
 Acta2 antibody  >1 publications with Tnnt2 and Acta2
 Tpm4 antibody  >1 publications with Tnnt2 and Tpm4
 Tpm2 antibody  >1 publications with Tnnt2 and Tpm2
 Tnni2 antibody  >1 publications with Tnnt2 and Tnni2
 Tnni1 antibody  >1 publications with Tnnt2 and Tnni1
 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Striated Muscle Contraction Pathway antibodies  Striated Muscle Contraction Pathway Diagram
Diseases associated with anti-Tnnt2 antibodyOrgans/Tissues associated with anti-Tnnt2 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >174 publications with Tnnt2 and Cardiovascular Diseases
 Heart Diseases Antibodies  >169 publications with Tnnt2 and Heart Diseases
 Cardiomyopathies Antibodies  >131 publications with Tnnt2 and Cardiomyopathies
 Cardiomyopathy, Hypertrophic Antibodies  >106 publications with Tnnt2 and Cardiomyopathy, Hypertrophic
 Cardiomyopathy, Hypertrophic, Familial Antibodies  >49 publications with Tnnt2 and Cardiomyopathy, Hypertrophic, Familial
 Cardiomyopathy, Dilated Antibodies  >47 publications with Tnnt2 and Cardiomyopathy, Dilated
 Cardiomegaly Antibodies  >47 publications with Tnnt2 and Cardiomegaly
 Hypertrophy Antibodies  >41 publications with Tnnt2 and Hypertrophy
 Heart Failure Antibodies  >40 publications with Tnnt2 and Heart Failure
 Death, Sudden, Cardiac Antibodies  >37 publications with Tnnt2 and Death, Sudden, Cardiac
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >132 publications with Tnnt2 and Heart
 Embryonic Tissue Antibodies  >18 publications with Tnnt2 and Embryonic Tissue
 Lung Antibodies  >5 publications with Tnnt2 and Lung
 Connective Tissue Antibodies  >3 publications with Tnnt2 and Connective Tissue
 Prostate Antibodies  >2 publications with Tnnt2 and Prostate
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