Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow TP53BP1 rightarrow Monoclonal TP53BP1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Peroxisome Proliferator-Activated Receptor gamma (PPAR-gamma... ELISA Kit
 • Akt, pan (Akt1) Antibody
 • Transferrin Receptor (TFRC) Antibody
 • IDO (IDO1) Recombinant Protein
 • Telomeric repeat-binding factor 2 (TERF2) ELISA Kit
 • Influenza A Antibody
 • cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibit... ELISA Kit
 • SSB Recombinant Protein
 • Methamphetamine Antibody
 • BDNF ELISA Kit
 • RBC Antibody
 • Thioredoxin Reductase (NTR) Recombinant Protein
 • Caspase-8 (Caspase-8) (CASP8) ELISA Kit
 • S100 Calcium Binding Protein ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-TP53BP1 antibody :: Mouse anti-Human Tumor Protein p53 Binding Protein 1 (TP53BP1) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2090542 anti-TP53BP1 antibody
Unit / Price
0.02 mg  /  $175 +1 FREE 8GB USB
0.1 mg  /  $340 +1 FREE 8GB USB
0.2 mg  /  $475 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tumor Protein p53 Binding Protein 1 (TP53BP1), Monoclonal Antibody

 Also Known As   

Monoclonal Antibody to Tumor Protein p53 Binding Protein 1 (TP53BP1)

 Product Synonym Names    53BP1; p53BP1; p202
 Product Gene Name   

anti-TP53BP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    AF078776 mRNA
 3D Structure    ModBase 3D Structure for Q12888
Section Bar
 Clonality    Monoclonal
 Host    Mouse
 Species Reactivity    Human
Section Bar
 Specificity    The antibody is a mouse monoclonal antibody raised against TP53BP1. It has been selected for its ability to recognize TP53BP1 in immunohistochemical staining and western blotting.
 Purity/Purification    Antigen-specific affinity chromatography followed by Protein A affinity chromatography
 Form/Format    Liquid
 Concentration    1mg/mL (lot specific)
Section Bar
 Buffer Formulation    PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Section Bar
 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of anti-TP53BP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Applications Tested/Suitable for anti-TP53BP1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for TP53BP1. It may not necessarily be applicable to this product.
 NCBI GI #    213972634
 NCBI GeneID    7158
 NCBI Accession #    NP_001135451.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001141979.2 [Other Products]
Section Bar
 UniProt Primary Accession #    Q12888 [Other Products]
 UniProt Secondary Accession #    Q2M1Z7; Q4LE46; Q5FWZ3; Q7Z3U4; F8VY86 [Other Products]
 UniProt Related Accession #    Q12888 [Other Products]
 Molecular Weight    213,989 Da
Table BarTOPTable Bar
 NCBI Official Full Name    TP53-binding protein 1 isoform 2
 NCBI Official Synonym Full Names    tumor protein p53 binding protein 1
 NCBI Official Symbol    TP53BP1 [Similar Products]
 NCBI Official Synonym Symbols   
TP53; p202; 53BP1; TDRD30; p53BP1
[Similar Products]
 NCBI Protein Information    TP53-binding protein 1; tumor suppressor p53-binding protein 1
 UniProt Protein Name    TP53-binding protein 1
 Protein Family    Tumor suppressor p53-binding protein
 UniProt Gene Name    TP53BP1 [Similar Products]
 UniProt Synonym Gene Names    p53BP1 [Similar Products]
Section Bar
 NCBI Summary for TP53BP1    This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Section Bar
 UniProt Comments for TP53BP1    53BP1: a DNA damage checkpoint protein that interacts with HDAC4 protein to mediate the DNA damage response. Inhibits E2F1-mediated apoptosis in prostate cancer cells. Recruited to double strand breaks via the binding of its Tudor domain to dimethylated H3 K20. Asymmetrically dimethylated on Arg residues by PRMT1. Methylation is required for DNA binding. Binds to the central domain of p53. Interacts with Artemis. Interacts with histone H2AFX and this requires phosphorylation of H2AFX on S139. Interacts with histone H4 that has been dimethylated at K20. Has low affinity for histone H4 containing monomethylated K20. Does not bind histone H4 containing unmethylated or trimethylated K20. Has low affinity for histone H3 that has been dimethylated on K79. Does not bind unmethylated histone H3. Phosphorylated at basal level in the absence of DNA damage. Hyper-phosphorylated in an ATM-dependent manner in response to DNA damage induced by ionizing radiation. Hyper-phosphorylated in an ATR-dependent manner in response to DNA damage induced by UV irradiation. Two alternatively spliced human isoforms have been observed.

Protein type: DNA repair, damage; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 15q15.3

Cellular Component: chromosome, telomeric region; cytoplasm; nuclear body; nuclear chromosome, telomeric region; nucleoplasm; nucleus; replication fork

Molecular Function: damaged DNA binding; methylated histone residue binding; p53 binding; protein binding; telomeric DNA binding

Biological Process: DNA damage checkpoint; double-strand break repair via nonhomologous end joining; positive regulation of isotype switching; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein homooligomerization; protein sumoylation; response to DNA damage stimulus; transcription, DNA-dependent
Table BarTOPTable Bar
 Research Articles on TP53BP1    1. Co-localization of gammaH2AX and 53BP1 indicates promotion of (in)effective nonhomologous end-joining repair mechanisms at sites of DSB. Moreover, gammaH2AX/53BP1 foci distribution presumably reveals a non-random spatial organization of the genome in MDS and AML.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-TP53BP1 antibodyPathways associated with anti-TP53BP1 antibody
 Reference Product  PubMed Publications
 ATM antibody  >149 publications with TP53BP1 and ATM
 H2AFX antibody  >145 publications with TP53BP1 and H2AFX
 MDC1 antibody  >74 publications with TP53BP1 and MDC1
 RNF168 antibody  >46 publications with TP53BP1 and RNF168
 CHEK2 antibody  >28 publications with TP53BP1 and CHEK2
 RAD50 antibody  >23 publications with TP53BP1 and RAD50
 MRE11A antibody  >20 publications with TP53BP1 and MRE11A
 PRKDC antibody  >9 publications with TP53BP1 and PRKDC
 XRCC6 antibody  >8 publications with TP53BP1 and XRCC6
 PAXIP1 antibody  >8 publications with TP53BP1 and PAXIP1
 Products by Pathway  Pathway Diagram
 ATM Signaling Network In Development And Disease Pathway antibodies  ATM Signaling Network In Development And Disease Pathway Diagram
 ATM Signaling Pathway antibodies  ATM Signaling Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 DNA Double Strand Break Response Pathway antibodies  DNA Double Strand Break Response Pathway Diagram
 DNA Double-Strand Break Repair Pathway antibodies  DNA Double-Strand Break Repair Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 G2/M Checkpoints Pathway antibodies  G2/M Checkpoints Pathway Diagram
 G2/M DNA Damage Checkpoint Pathway antibodies  G2/M DNA Damage Checkpoint Pathway Diagram
 HDR Through Homologous Recombination (HR) Or Single Strand Annealing (SSA) Pathway antibodies  HDR Through Homologous Recombination (HR) Or Single Strand Annealing (SSA) Pathway Diagram
Diseases associated with anti-TP53BP1 antibodyOrgans/Tissues associated with anti-TP53BP1 antibody
 Disease Name  Pubmed Publications
 Ataxia Antibodies  >127 publications with TP53BP1 and Ataxia
 Breast Neoplasms Antibodies  >57 publications with TP53BP1 and Breast Neoplasms
 Gastrointestinal Diseases Antibodies  >18 publications with TP53BP1 and Gastrointestinal Diseases
 Lung Neoplasms Antibodies  >17 publications with TP53BP1 and Lung Neoplasms
 Adenocarcinoma Antibodies  >17 publications with TP53BP1 and Adenocarcinoma
 Ovarian Neoplasms Antibodies  >16 publications with TP53BP1 and Ovarian Neoplasms
 Carcinoma, Squamous Cell Antibodies  >16 publications with TP53BP1 and Carcinoma, Squamous Cell
 Neoplasms, Experimental Antibodies  >13 publications with TP53BP1 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >13 publications with TP53BP1 and Nervous System Diseases
 Lung Diseases Antibodies  >13 publications with TP53BP1 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >47 publications with TP53BP1 and Blood
 Lung Antibodies  >25 publications with TP53BP1 and Lung
 Skin Antibodies  >18 publications with TP53BP1 and Skin
 Bone Antibodies  >16 publications with TP53BP1 and Bone
 Prostate Antibodies  >13 publications with TP53BP1 and Prostate
 Bone Marrow Antibodies  >11 publications with TP53BP1 and Bone Marrow
 Brain Antibodies  >9 publications with TP53BP1 and Brain
 Lymph Node Antibodies  >7 publications with TP53BP1 and Lymph Node
 Thyroid Antibodies  >4 publications with TP53BP1 and Thyroid
 Pancreas Antibodies  >3 publications with TP53BP1 and Pancreas
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions