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anti-TNFRSF12A antibody :: Mouse Tweak Receptor Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS606293 anti-TNFRSF12A antibody
Unit / Price
0.025 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tweak Receptor (TNFRSF12A), Monoclonal Antibody

 Also Known As   

Tweak Receptor (TWEAK R, TWEAKR, CD266, Fibroblast Growth Factor-inducible Immediate Early Response Protein 14, FGF-inducible 14, FN14, Tumor Necrosis Factor Receptor Superfamily Member 12A, TNFRSF12A, Type I Transmembrane Protein Fn14)

 Product Synonym Names    Anti -Tweak Receptor (TWEAK R, TWEAKR, CD266, Fibroblast Growth Factor-inducible Immediate Early Response Protein 14, FGF-inducible 14, FN14, Tumor Necrosis Factor Receptor Superfamily Member 12A, TNFRSF12A, Type I Transmembrane Protein Fn14)
 Product Gene Name   

anti-TNFRSF12A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 16; NC_000016.9 (3070313..3072384). Location: 16p13.3
 OMIM    605914
 3D Structure    ModBase 3D Structure for Q9NP84
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    9i122
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes human CD266 at ~14kD.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography
 Form/Format    Supplied as a liquid in PBS, pH7.2, 0.09% sodium azide.
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 Immunogen    Human CD266 transfected P815.
 Hybridoma    P3U1 myeloma cells with spleen cells from Balb/c mice.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-TNFRSF12A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-TNFRSF12A antibody

   Tweak Receptor also known as CD266, a 14kD type I transmembrane glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF12A) expressed by a variety of tissues, including the heart, lung and kidney, and at elevated levels by human brain and liver tumors. The interaction between CD266 and its ligand CD255 (TWEAK), induces the proliferation and migration of endothelial cells and also angiogenesis, and studies have shown that CD255-induced apoptosis of some tumor cell lines is mediated by CD266
 Product Categories/Family for anti-TNFRSF12A antibody    Antibodies; Abs to Receptors
 Applications Tested/Suitable for anti-TNFRSF12A antibody   

Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

 Application Notes for anti-TNFRSF12A antibody    Suitable for use in Flow Cytometry, Immunohistochemistry and Western Blot..
Dilution: Flow Cytometry: 1:25-1:200; 10ul labels 10e6 cells in 100ul.
Immunohistochemistry: Frozen sections
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NCBI/Uniprot data below describe general gene information for TNFRSF12A. It may not necessarily be applicable to this product.
 NCBI GI #    7706186
 NCBI GeneID    51330
 NCBI Accession #    NP_057723.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_016639.2 [Other Products]
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 UniProt Primary Accession #    Q9NP84 [Other Products]
 UniProt Secondary Accession #    Q9HCS0; D3DUA6 [Other Products]
 UniProt Related Accession #    Q9NP84 [Other Products]
 Molecular Weight    13,911 Da [Similar Products]
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 NCBI Official Full Name    tumor necrosis factor receptor superfamily member 12A
 NCBI Official Synonym Full Names    tumor necrosis factor receptor superfamily, member 12A
 NCBI Official Symbol    TNFRSF12A [Similar Products]
 NCBI Official Synonym Symbols   
FN14; CD266; TWEAKR
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 12A; tweak-receptor; FGF-inducible 14; type I transmembrane protein Fn14; fibroblast growth factor-inducible immediate-early response protein 14
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 12A
 UniProt Synonym Protein Names   
Fibroblast growth factor-inducible immediate-early response protein 14; FGF-inducible 14; Tweak-receptor
 Protein Family    Tumor necrosis factor receptor superfamily
 UniProt Gene Name    TNFRSF12A [Similar Products]
 UniProt Synonym Gene Names    FN14; FGF-inducible 14; TweakR [Similar Products]
 UniProt Entry Name    TNR12_HUMAN
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 UniProt Comments for TNFRSF12A    TweakR: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. Associates with TRAF1 and TRAF2, and probably also with TRAF3. By FGF1 and phorbol ester. Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell development/differentiation; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: ruffle; cell surface; plasma membrane; integral to membrane

Molecular Function: protein binding

Biological Process: positive regulation of apoptosis; substrate-bound cell migration, cell attachment to substrate; positive regulation of axon extension; angiogenesis; regulation of angiogenesis
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 Research Articles on TNFRSF12A    1. TWEAK/Fn14, by activating macrophages, could be ovarian tumor suppressors.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TNFRSF12A antibodyPathways associated with anti-TNFRSF12A antibody
 Reference Product  PubMed Publications
 TNFSF12 antibody  >3 publications with TNFRSF12A and TNFSF12
 TNFRSF25 antibody  >1 publications with TNFRSF12A and TNFRSF25
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 TWEAK Signaling Pathway antibodies  TWEAK Signaling Pathway Diagram
Diseases associated with anti-TNFRSF12A antibodyOrgans/Tissues associated with anti-TNFRSF12A antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >11 publications with TNFRSF12A and Necrosis
 Inflammation Antibodies  >7 publications with TNFRSF12A and Inflammation
 Neoplasms Antibodies  >5 publications with TNFRSF12A and Neoplasms
 Disease Models, Animal Antibodies  >2 publications with TNFRSF12A and Disease Models, Animal
 Heart Diseases Antibodies  >2 publications with TNFRSF12A and Heart Diseases
 Neoplasms, Experimental Antibodies  >2 publications with TNFRSF12A and Neoplasms, Experimental
 Adenocarcinoma Antibodies  >1 publications with TNFRSF12A and Adenocarcinoma
 Nervous System Diseases Antibodies  >1 publications with TNFRSF12A and Nervous System Diseases
 Lung Neoplasms Antibodies  >1 publications with TNFRSF12A and Lung Neoplasms
 Kidney Diseases Antibodies  >1 publications with TNFRSF12A and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >4 publications with TNFRSF12A and Muscle
 Vascular Antibodies  >4 publications with TNFRSF12A and Vascular
 Lung Antibodies  >4 publications with TNFRSF12A and Lung
 Blood Antibodies  >3 publications with TNFRSF12A and Blood
 Eye Antibodies  >2 publications with TNFRSF12A and Eye
 Kidney Antibodies  >2 publications with TNFRSF12A and Kidney
 Heart Antibodies  >2 publications with TNFRSF12A and Heart
 Brain Antibodies  >1 publications with TNFRSF12A and Brain
 Intestine Antibodies  >1 publications with TNFRSF12A and Intestine
 Testis Antibodies  >1 publications with TNFRSF12A and Testis
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