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anti-TYR antibody :: Mouse Tyrosinase Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245263
Immunohistochemistry (IHC)
Unit / Price
0.125 mL  /  $530 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Tyrosinase, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal (IgG2a) to Human Tyrosinase

 Product Synonym Names    Anti-Tyrosinase Antibody IHC-plus; TYR; CMM8; LB24-AB; SHEP3; SK29-AB; Monophenol monooxygenase; Tumor rejection antigen AB; OCA1A; Tyrosinase; OCAIA; Human Tyrosinase
 Product Gene Name   

anti-TYR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 606952
 3D Structure    ModBase 3D Structure for P14679
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 Clonality    Monoclonal
 Isotype    IgG2a
 Host    Mouse
 Species Reactivity    Cat, Dog, Human
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 Specificity    Recognizes a cluster of proteins between 70-80kD, identified as human tyrosinase. Occasionally a minor band at 55kD is also detected. Does not cross-react with MAGE-1 and tyrosinase-related protein 1, TRP-1/gp75. Species cross-reactivity: canine and feline. Weak cross-reactivity with mouse.
 Purity/Purification    Protein A Purified
 Form/Format    PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide.
 Concentration    0.2 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Recombinant tyrosinase protein. Epitope: 1-433.
 Immunogen Type    Recombinant protein
 Immunogen    Tyrosinase antibody was raised against recombinant tyrosinase protein. Epitope: 1-433.
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 Preparation and Storage    +4 degree C or -20 degree C, Avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-TYR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-TYR antibody

   Tyrosinase is a copper containing oxidase that catalyzes the first step in the conversion of tyrosine to melanin, and other polyphenolic compounds. It also catalyzes the rate-limiting conversion of tyrosine to DOPA. Mutations in tyrosinase are the cause of oculocutaneous albinism 1A.
 Applications Tested/Suitable for anti-TYR antibody   

Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-TYR antibody    ELISA, ICC, IF, IHC-P (10 ug/ml), WB (1 - 2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-TYR antibody    Anti-Tyrosinase antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
anti-TYR antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for TYR. It may not necessarily be applicable to this product.
 NCBI GI #    4507753
 NCBI GeneID    7299
 NCBI Accession #    NP_000363.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000372.4 [Other Products]
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 UniProt Primary Accession #    P14679 [Other Products]
 UniProt Secondary Accession #    Q15675; Q15676; Q15680; Q8TAK4; Q9BYY0; Q9BZX1 [Other Products]
 UniProt Related Accession #    P14679 [Other Products]
 Molecular Weight    42,914 Da
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 NCBI Official Full Name    tyrosinase
 NCBI Official Synonym Full Names    tyrosinase
 NCBI Official Symbol    TYR [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    tyrosinase; LB24-AB; SK29-AB; monophenol monooxygenase; oculocutaneous albinism IA; tumor rejection antigen AB
 UniProt Protein Name    Tyrosinase
 UniProt Synonym Protein Names   
LB24-AB; Monophenol monooxygenase; SK29-AB; Tumor rejection antigen AB
 Protein Family    Tyrosinase
 UniProt Gene Name    TYR [Similar Products]
 UniProt Entry Name    TYRO_HUMAN
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 NCBI Summary for TYR    The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene. [provided by RefSeq, Oct 2008]
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 UniProt Comments for TYR    TYR: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone. Increased expression after UVB irradiation. Belongs to the tyrosinase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cofactor and Vitamin Metabolism - riboflavin; Amino Acid Metabolism - tyrosine; EC; Oxidoreductase; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q14.3

Cellular Component: lysosome; perinuclear region of cytoplasm; cytoplasm; melanosome membrane; melanosome; integral to membrane; Golgi-associated vesicle

Molecular Function: protein binding; copper ion binding; protein homodimerization activity; protein heterodimerization activity; monophenol monooxygenase activity

Biological Process: cell proliferation; visual perception; thymus development; melanin biosynthetic process from tyrosine; eye pigment biosynthetic process

Disease: Albinism, Ocular, With Sensorineural Deafness; Albinism, Oculocutaneous, Type Ib; Albinism, Oculocutaneous, Type Ia; Skin/hair/eye Pigmentation, Variation In, 3
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 Research Articles on TYR    1. cAMP-PKA-CREB-activated microphthalmia-associated transcription factor and tyrosinase expression is inhibited by the novel novel adamantyl benzylbenzamide derivative, AP736
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-TYR antibodyPathways associated with anti-TYR antibody
 Reference Product  PubMed Publications
 TYRP1 antibody  >118 publications with TYR and TYRP1
 TAT antibody  >97 publications with TYR and TAT
 MLANA antibody  >16 publications with TYR and MLANA
 SILV antibody  >13 publications with TYR and SILV
 TPO antibody  >10 publications with TYR and TPO
 GOT1 antibody  >5 publications with TYR and GOT1
 DDC antibody  >5 publications with TYR and DDC
 Products by Pathway  Pathway Diagram
 (S)-reticuline Biosynthesis Pathway antibodies  (S)-reticuline Biosynthesis Pathway Diagram
 (S)-reticuline Biosynthesis II Pathway antibodies  (S)-reticuline Biosynthesis II Pathway Diagram
 Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway antibodies  Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway Diagram
 Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway antibodies  Catecholamine Biosynthesis, Tyrosine => Dopamine => Noradrenaline => Adrenaline Pathway Diagram
 Dopamine Metabolism Pathway antibodies  Dopamine Metabolism Pathway Diagram
 L-dopachrome Biosynthesis Pathway antibodies  L-dopachrome Biosynthesis Pathway Diagram
 L-dopachrome Biosynthesis Pathway antibodies  L-dopachrome Biosynthesis Pathway Diagram
 Melanogenesis Pathway antibodies  Melanogenesis Pathway Diagram
 Melanogenesis Pathway antibodies  Melanogenesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
Diseases associated with anti-TYR antibodyOrgans/Tissues associated with anti-TYR antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >793 publications with TYR and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >420 publications with TYR and Cardiovascular Diseases
 Pain Antibodies  >400 publications with TYR and Pain
 Inflammation Antibodies  >368 publications with TYR and Inflammation
 Melanoma Antibodies  >342 publications with TYR and Melanoma
 Neoplasms, Experimental Antibodies  >278 publications with TYR and Neoplasms, Experimental
 Liver Diseases Antibodies  >213 publications with TYR and Liver Diseases
 Necrosis Antibodies  >210 publications with TYR and Necrosis
 Hypertension Antibodies  >207 publications with TYR and Hypertension
 Liver Neoplasms Antibodies  >181 publications with TYR and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >520 publications with TYR and Skin
 Eye Antibodies  >274 publications with TYR and Eye
 Thyroid Antibodies  >177 publications with TYR and Thyroid
 Connective Tissue Antibodies  >138 publications with TYR and Connective Tissue
 Mammary Gland Antibodies  >41 publications with TYR and Mammary Gland
 Ear Antibodies  >29 publications with TYR and Ear
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