NP_116262.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ubiquitin-associated and SH3 domain-containing protein B
NCBI Official Synonym Full Names
ubiquitin associated and SH3 domain containing B
NCBI Protein Information
ubiquitin-associated and SH3 domain-containing protein B; T-cell ubiquitin ligand 2; cbl-interacting protein p70; Cbl-interacting protein Sts-1; nm23-phosphorylated unknown substrate; tyrosine-protein phosphatase STS1/TULA2; suppressor of T-cell receptor signaling 1; SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling 1, nm23-phosphorylated unknown substrate
UniProt Protein Name
Ubiquitin-associated and SH3 domain-containing protein B
UniProt Synonym Protein Names
Cbl-interacting protein p70; Suppressor of T-cell receptor signaling 1; STS-1; T-cell ubiquitin ligand 2; TULA-2; Tyrosine-protein phosphatase STS1/TULA2
UniProt Synonym Gene Names
UniProt Entry Name
UBS3B_HUMAN
NCBI Summary for UBASH3B
This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008]
UniProt Comments for UBASH3B
Function: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. Ref.7 Ref.8
Catalytic activity: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. Ref.8
Subunit structure: Homodimer
By similarity. Interacts with CBL. Part of a complex containing CBL and activated EGFR. Interacts with ubiquitin and with mono-ubiquitinated proteins. Ref.7
Subcellular location: Cytoplasm
By similarity. Nucleus
Potential.
Sequence similarities: Contains 1 SH3 domain.Contains 1 UBA domain.
Sequence caution: The sequence AAL16953.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB85545.1 differs from that shown. Reason: Erroneous initiation.
Research Articles on UBASH3B
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Products associated with anti-UBASH3B antibody
Diseases associated with anti-UBASH3B antibody
Organs/Tissues associated with anti-UBASH3B antibody
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