NP_001189418.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ubiquitin-conjugating enzyme E2 G2 isoform 3
NCBI Official Synonym Full Names
ubiquitin-conjugating enzyme E2G 2
NCBI Official Synonym Symbols
NCBI Protein Information
ubiquitin-conjugating enzyme E2 G2; ubiquitin-protein ligase G2; ubiquitin carrier protein G2; ubiquitin conjugating enzyme 7; ubiquitin conjugating enzyme G2; ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast); ubiquitin-conjugating enzyme E2G 2 (homologous to yeast UBC7)
UniProt Protein Name
Ubiquitin-conjugating enzyme E2 G2
UniProt Synonym Protein Names
Ubiquitin carrier protein G2; Ubiquitin-protein ligase G2
UniProt Entry Name
UB2G2_HUMAN
NCBI Summary for UBE2G2
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
UniProt Comments for UBE2G2
UBE2G2: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Involved in endoplasmic reticulum- associated degradation (ERAD). Belongs to the ubiquitin-conjugating enzyme family.
Protein type: EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase; Ligase; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: endoplasmic reticulum; cytosol
Molecular Function: identical protein binding; protein binding; small conjugating protein ligase activity; ubiquitin protein ligase binding; ubiquitin-protein ligase activity; ATP binding; ligase activity
Biological Process: ubiquitin-dependent protein catabolic process; ER-associated protein catabolic process; cellular protein catabolic process; protein amino acid N-linked glycosylation via asparagine
Research Articles on UBE2G2
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Products associated with anti-UBE2G2 antibody
Pathways associated with anti-UBE2G2 antibody
Diseases associated with anti-UBE2G2 antibody
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