NP_004214.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,086 Da
NCBI Official Full Name
ubiquitin/ISG15-conjugating enzyme E2 L6 isoform 1
NCBI Official Synonym Full Names
ubiquitin-conjugating enzyme E2L 6
NCBI Official Synonym Symbols
NCBI Protein Information
ubiquitin/ISG15-conjugating enzyme E2 L6; ubiquitin-protein ligase L6; ubiquitin carrier protein L6; retinoic acid induced gene B protein; retinoic acid-induced gene B protein
UniProt Protein Name
Ubiquitin/ISG15-conjugating enzyme E2 L6
UniProt Synonym Protein Names
Retinoic acid-induced gene B protein; RIG-B; UbcH8; Ubiquitin carrier protein L6; Ubiquitin-protein ligase L6
UniProt Synonym Gene Names
UniProt Entry Name
UB2L6_HUMAN
NCBI Summary for UBE2L6
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]
UniProt Comments for UBE2L6
UBE2L6: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. Belongs to the ubiquitin-conjugating enzyme family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Ubiquitin ligase; Ubiquitin conjugating system; Ligase; EC 6.3.2.19
Chromosomal Location of Human Ortholog: 11q12
Cellular Component: cytosol
Molecular Function: protein binding; ISG15 conjugating enzyme activity; ubiquitin-protein ligase activity; ligase activity
Biological Process: modification-dependent protein catabolic process; ISG15-protein conjugation; cytokine and chemokine mediated signaling pathway; protein ubiquitination; innate immune response; protein modification process; negative regulation of interferon type I production
Research Articles on UBE2L6
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Products associated with anti-UBE2L6 antibody
Pathways associated with anti-UBE2L6 antibody
Diseases associated with anti-UBE2L6 antibody
Organs/Tissues associated with anti-UBE2L6 antibody
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