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anti-UBE2S antibody :: Mouse anti-Human UBE2S Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS200167
Unit / Price
0.05 mL  /  $240 +1 FREE 8GB USB
0.1 mL  /  $315 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

UBE2S, Monoclonal Antibody

★Popular Item★
 Also Known As   

UBE2S antibody

 Product Synonym Names    ubiquitin-conjugating enzyme E2S; E2-EPF; E2EPF; EPF5; ubiquitin-conjugating enzyme E2S AA409170; MGC101982; uBE2S; ubiquitin carrier protein S; ubiquitin protein ligase S; ubiquitin conjugating enzyme E2 24 kD; ubiquitin conjugating enzyme E2S
 Product Gene Name   

anti-UBE2S antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M91670 mRNA
 3D Structure    ModBase 3D Structure for Q16763
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 Clonality    Monoclonal
 Isotype    IgG2a, k
 Clone Number    AT2C12
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    By protein-G affinity chromatography
 Form/Format    Liquid. In phosphate-buffered saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol.
 Concentration    1mg/ml (lot specific)
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 Antigen Species    Human
 Immunogen    Recombinant human UBE2S (1-222aa) purified from E. coli
 Clone Note    Anti-human UBE2S mAb, clone AT2C12, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human UBE2S protein.
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 Preparation and Storage    Can be stored at 4 degree C.
For long term storage, aliquot and store at -20 degree C.
Avoid repeated freezing and thawing cycles.
 Other Notes    Small volumes of anti-UBE2S antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-UBE2S antibody

   UBE2S, also known as ubiquitin-conjugating enzyme E2S, is a member of the ubiquitin-conjugating enzyme family. This protein is able to form a thiol ester linkage with ubiquitin in an ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. It catalyzes the covalent attachment of ubiquitin to other proteins.
 Product Categories/Family for anti-UBE2S antibody    Ubiquitination
 Applications Tested/Suitable for anti-UBE2S antibody   

ELISA (EIA), Western Blot (WB), Flow Cytometry (FC/FACS), Immunocytochemistry (ICC), Immunofluorescence (IF)

 Application Notes for anti-UBE2S antibody    WB/IF: 1:250 ~ 500.
Recommended starting dilution is 1:250
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 Western Blot (WB) of anti-UBE2S antibody    The Cell lysates (10ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human UBE2S antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system. Lane 1.: 293T cell lysate Lane 2.: UBE2S transfected 293T cell lysate
anti-UBE2S antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-UBE2S antibody    Immunofluorescence of human HeLa cells stained with Phalloidin-TRITC (Red) for Actin staining and monoclonal anti-human UBE2S antibody (1:500) with Alexa 488 (Green).
anti-UBE2S antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for UBE2S. It may not necessarily be applicable to this product.
 NCBI GI #    112382377
 NCBI GeneID    27338
 NCBI Accession #    NP_055316.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_014501.2 [Other Products]
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 UniProt Primary Accession #    Q16763 [Other Products]
 UniProt Secondary Accession #    Q9BTC1 [Other Products]
 UniProt Related Accession #    Q16763 [Other Products]
 Molecular Weight    23,845 Da
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 NCBI Official Full Name    ubiquitin-conjugating enzyme E2 S
 NCBI Official Synonym Full Names    ubiquitin conjugating enzyme E2 S
 NCBI Official Symbol    UBE2S [Similar Products]
 NCBI Official Synonym Symbols   
EPF5; E2EPF; E2-EPF
[Similar Products]
 NCBI Protein Information    ubiquitin-conjugating enzyme E2 S
 UniProt Protein Name    Ubiquitin-conjugating enzyme E2 S
 UniProt Synonym Protein Names   
E2 ubiquitin-conjugating enzyme S; E2-EPF; Ubiquitin carrier protein S; Ubiquitin-conjugating enzyme E2-24 kDa; Ubiquitin-conjugating enzyme E2-EPF5; Ubiquitin-protein ligase S
 Protein Family    Ubiquitin-conjugating enzyme
 UniProt Gene Name    UBE2S [Similar Products]
 UniProt Synonym Gene Names    E2EPF [Similar Products]
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 NCBI Summary for UBE2S    This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]
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 UniProt Comments for UBE2S    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit (PubMed:19820702, PubMed:19822757, PubMed:27259151). Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A (PubMed:16819549). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination (PubMed:20061386, PubMed:20622874).
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Product References and Citations for anti-UBE2S antibody

   Ye Y, et al. (2009) Nat Rev Mol Cell Biol, 10 (11):755-64.; Windheim M, et al. (2008) Biochem J, 409 (3):723-9.
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 Research Articles on UBE2S    1. High UBE2S expression is associated with drug resistance in glioblastoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-UBE2S antibodyPathways associated with anti-UBE2S antibody
 Reference Product  PubMed Publications
 CDC20 antibody  >5 publications with UBE2S and CDC20
 ANAPC11 antibody  >4 publications with UBE2S and ANAPC11
 CDC27 antibody  >2 publications with UBE2S and CDC27
 ANAPC15 antibody  >1 publications with UBE2S and ANAPC15
 CDC23 antibody  >1 publications with UBE2S and CDC23
 UBC antibody  >1 publications with UBE2S and UBC
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing: Ubiquitination & Proteasome Degradation Pathway antibodies  Antigen Processing: Ubiquitination & Proteasome Degradation Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Protein Ubiquitination Pathway antibodies  Protein Ubiquitination Pathway Diagram
 Synthesis Of Active Ubiquitin: Roles Of E1 And E2 Enzymes Pathway antibodies  Synthesis Of Active Ubiquitin: Roles Of E1 And E2 Enzymes Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
Diseases associated with anti-UBE2S antibodyOrgans/Tissues associated with anti-UBE2S antibody
 Disease Name  Pubmed Publications
 Liver Neoplasms Antibodies  >2 publications with UBE2S and Liver Neoplasms
 Neoplasm Invasiveness Antibodies  >2 publications with UBE2S and Neoplasm Invasiveness
 Lung Diseases Antibodies  >1 publications with UBE2S and Lung Diseases
 Kidney Diseases Antibodies  >1 publications with UBE2S and Kidney Diseases
 Lung Neoplasms Antibodies  >1 publications with UBE2S and Lung Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with UBE2S and Carcinoma, Hepatocellular
 Liver Diseases Antibodies  >1 publications with UBE2S and Liver Diseases
 Cell Transformation, Neoplastic Antibodies  >1 publications with UBE2S and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with UBE2S and Brain
 Liver Antibodies  >2 publications with UBE2S and Liver
 Blood Antibodies  >1 publications with UBE2S and Blood
 Kidney Antibodies  >1 publications with UBE2S and Kidney
 Lung Antibodies  >1 publications with UBE2S and Lung
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