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anti-ULBP-3 antibody :: Mouse anti-Human ULBP-3 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS690155 anti-ULBP-3 antibody
Unit / Price
0.1 mg  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ULBP-3, Monoclonal Antibody

 Also Known As   

Mouse Anti-Human ULBP-3

 Product Synonym Names    ULBP1; RAET1I
 Product Gene Name   

anti-ULBP-3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 6; NC_000006.12 (150062723..150069194, complement). Location: 6q25
 OMIM    605699
 3D Structure    ModBase 3D Structure for Q9BZM4
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 Clonality    Monoclonal
 Isotype    IgG2
 Clone Number    6E12
 Host    Mouse
 Species Reactivity    Human
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 Form/Format    Lyophilized
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 Antibody Generation    This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with Human ULBP-3 recombinant protein.
 Reconstitution    Reconstitute the antibody with 200 ul sterile PBS and the final concentration is 500 ug/ml.
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 Preparation and Storage    Lyophilized samples are stable for 2 years from date of receipt when stored at -70 degree C. Reconstituted antibody can be aliquoted and stored frozen at < -20 degree C for at least for six months without detectable loss of activity.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-ULBP-3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ULBP-3 antibody

   ULBP-1, -2, and -3 were originally identified as ligands for the human cytomegalovirus glycoprotein UL16 and designated UL16-binding proteins (ULBP). These proteins are distantly related to major histocompatibility class I (MHC I) molecules, possessing the alpha 1 and alpha 2 Ig-like domains, but lacking the alpha 3 domain. Unlike MHC Class I, they have no capacity to bind peptide or interact with beta2-microglobulin. ULBP-1, -2, and -3 are known to bind to human NKG2D, an activating receptor expressed on NK cells, NKT cells, gamma delta T cells, and CD8+ alpha beta T cells.
 Applications Tested/Suitable for anti-ULBP-3 antibody   

Western Blot (WB)

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NCBI/Uniprot data below describe general gene information for ULBP-3. It may not necessarily be applicable to this product.
 NCBI GI #    13375656
 NCBI GeneID    79465
 NCBI Accession #    NP_078794.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_024518.1 [Other Products]
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 UniProt Primary Accession #    Q9BZM4 [Other Products]
 UniProt Secondary Accession #    Q5VY82; Q8IZX5; Q8TE75 [Other Products]
 UniProt Related Accession #    Q9BZM4 [Other Products]
 Molecular Weight    27,949 Da
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 NCBI Official Full Name    NKG2D ligand 3
 NCBI Official Synonym Full Names    UL16 binding protein 3
 NCBI Official Symbol    ULBP3 [Similar Products]
 NCBI Official Synonym Symbols   
RAET1N
[Similar Products]
 NCBI Protein Information    NKG2D ligand 3; N2DL-3; NKG2DL3; ALCAN-gamma; UL16-binding protein 3; retinoic acid early transcript 1N
 UniProt Protein Name    NKG2D ligand 3
 UniProt Synonym Protein Names   
ALCAN-gamma; Retinoic acid early transcript 1N
 UniProt Gene Name    ULBP3 [Similar Products]
 UniProt Synonym Gene Names    N2DL3; RAET1N; N2DL-3; NKG2DL3 [Similar Products]
 UniProt Entry Name    N2DL3_HUMAN
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 UniProt Comments for ULBP-3    Function: Ligand for the NKG2D receptor, together with at least ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. Has lower affinity for NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling responses than does ULBP2 or ULBP1.

Subunit structure: Does not bind to beta2-microglobulin. Interacts with human cytomegalovirus/HHV-5 protein UL142. Ref.7 Ref.10

Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor Ref.1.

Miscellaneous: The ULBPs are unusual members of the extended MHC class I superfamily, because they do not contain the alpha 3 domain and they lack a transmembrane domain. They are unlikely to present peptides.The region from chromosome 6q24.1-6q25.3 contains as many as 10 ULBP-related sequences, many of which are pseudogenes.

Sequence similarities: Belongs to the MHC class I family.
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 Research Articles on ULBP-3    1. A greater expression of ULBP3 has also been found in hair follicles in scalp biopsy specimens from patients with active disease
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ULBP-3 antibodyPathways associated with anti-ULBP-3 antibody
 Reference Product  PubMed Publications
 ULBP1 antibody  >48 publications with ULBP-3 and ULBP1
 KLRK1 antibody  >42 publications with ULBP-3 and KLRK1
 NCR1 antibody  >2 publications with ULBP-3 and NCR1
 RAE1 antibody  >1 publications with ULBP-3 and RAE1
 B2M antibody  >1 publications with ULBP-3 and B2M
 HLA-B antibody  >1 publications with ULBP-3 and HLA-B
 HCST antibody  >1 publications with ULBP-3 and HCST
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
Diseases associated with anti-ULBP-3 antibodyOrgans/Tissues associated with anti-ULBP-3 antibody
 Disease Name  Pubmed Publications
 Leukemia Antibodies  >7 publications with ULBP-3 and Leukemia
 Alopecia Areata Antibodies  >3 publications with ULBP-3 and Alopecia Areata
 Leukemia, Lymphocytic, Chronic, B-Cell Antibodies  >2 publications with ULBP-3 and Leukemia, Lymphocytic, Chronic, B-Cell
 Leukemia, Myeloid Antibodies  >2 publications with ULBP-3 and Leukemia, Myeloid
 Leukemia, Lymphoid Antibodies  >2 publications with ULBP-3 and Leukemia, Lymphoid
 Carcinoma, Small Cell Antibodies  >2 publications with ULBP-3 and Carcinoma, Small Cell
 Glioma Antibodies  >2 publications with ULBP-3 and Glioma
 Multiple Myeloma Antibodies  >1 publications with ULBP-3 and Multiple Myeloma
 Neuroblastoma Antibodies  >1 publications with ULBP-3 and Neuroblastoma
 Leukemia, Promyelocytic, Acute Antibodies  >1 publications with ULBP-3 and Leukemia, Promyelocytic, Acute
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >5 publications with ULBP-3 and Lung
 Skin Antibodies  >3 publications with ULBP-3 and Skin
 Vascular Antibodies  >2 publications with ULBP-3 and Vascular
 Brain Antibodies  >1 publications with ULBP-3 and Brain
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