AAC40118.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
UNC-51-like kinase ULK1
NCBI Official Synonym Full Names
unc-51 like kinase 1
NCBI Protein Information
serine/threonine-protein kinase ULK1; unc-51-like kinase 1; serine/threonine-protein kinase Unc51.1
UniProt Protein Name
Serine/threonine-protein kinase ULK1
UniProt Synonym Protein Names
Serine/threonine-protein kinase Unc51.1; Unc-51-like kinase 1
UniProt Entry Name
ULK1_MOUSE
UniProt Comments for Ulk1
ULK1: Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation. Interacts with GABARAP and GABARAPL2. Interacts (via C- terminus) with ATG13/KIAA0652. Part of a complex consisting of ATG13/KIAA0652, ULK1 and RB1CC1. Associates with the mammalian target of rapamycin complex 1 (mTORC1) through an interaction with RPTOR; the association depends on nutrient conditions and is reduced during starvation. Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.
Protein type: EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Autophagy; Kinase, protein; Protein kinase, Other; Other group; ULK family
Cellular Component: neuron projection; cytoplasmic vesicle membrane; cell soma; membrane; cytoplasm; pre-autophagosomal structure membrane; autophagic vacuole; cytosol
Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; protein complex binding; Hsp90 protein binding; kinase activity; protein kinase binding; Rab GTPase binding; ATP binding; protein kinase activity
Biological Process: axon extension; protein amino acid autophosphorylation; neurite regeneration; negative regulation of collateral sprouting; signal transduction; protein amino acid phosphorylation; cerebellar granule cell differentiation; radial glia guided migration of granule cell; response to starvation; protein localization; peptidyl-serine phosphorylation; cellular response to nutrient levels; axonogenesis; regulation of gene expression; receptor internalization; Ras protein signal transduction; autophagy; regulation of autophagy; regulation of nerve growth factor receptor signaling pathway; phosphorylation; positive regulation of macroautophagy; positive regulation of autophagy; neurite development; autophagic vacuole formation
Research Articles on Ulk1
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Pathways associated with anti-Ulk1 antibody
Diseases associated with anti-Ulk1 antibody
Organs/Tissues associated with anti-Ulk1 antibody
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