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anti-PLAUR antibody :: Rat anti-Mouse Urokinase Plasminogen Activator Receptor Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS632008
Testing Data
Unit / Price
100 Tests  /  $670 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Urokinase Plasminogen Activator Receptor (PLAUR), Monoclonal Antibody

★Popular Item★
 Also Known As   

Urokinase Plasminogen Activator Receptor (U Plasminogen Activator Receptor, UPA Receptor, uPAR, U-PAR, CD87, CD87 Antigen, MO3, Monocyte Activation Antigen Mo3, Plasminogen Activator Urokinase Receptor, PLAUR, URKR) (PE)

 Product Synonym Names    Anti -Urokinase Plasminogen Activator Receptor (U Plasminogen Activator Receptor, UPA Receptor, uPAR, U-PAR, CD87, CD87 Antigen, MO3, Monocyte Activation Antigen Mo3, Plasminogen Activator Urokinase Receptor, PLAUR, URKR) (PE)
 Product Gene Name   

anti-PLAUR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (44150248..44174502, complement). Location: 19q13
 OMIM    173391
 3D Structure    ModBase 3D Structure for Q03405
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 Clonality    Monoclonal
 Isotype    IgG2A
 Clone Number    10K37
 Host    Rat
 Species Reactivity    Mouse
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 Specificity    Recognizes mouse uPAR. No crossreactvity with recombinant human uPAR in Western Blot.
 Purity/Purification    Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in saline, 0.5% BSA, 0.09% sodium azide. Labeled with R-Phycoerythrin (PE).
 Concentration    0.025 mg/ml (lot specific)
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 Immunogen    Recombinant protein corresponding to Leu24-Thr297 from mouse uPAR expressed in NS0 cells. UniProt Accession: P35456.
 Hybridoma    Fusion of a mouse myeloma with B cells obtained from a rat immunized with purified, NS0-derived, recombinant mouse uPAR
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 Preparation and Storage    Store product at 4C in the dark. DO NOT FREEZE! Stable at 4C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
 Other Notes    Small volumes of anti-PLAUR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-PLAUR antibody

   CD87, a 45- to 60kD protein, consists of three structurally homologous domains of ~90aa, designated D1, D2, and D3, each containing a conserved arrangement of disulfide bonds and separated by short interdomain linker sequences. uPAR exists in various molecular forms; heavily glycosylated, a cleaved form, a soluble form and spliced forms. CD87 is expressed by monocytes/macrophages, neutrophils, endothelial, smooth muscle cells and epithelial cells. CD87 is overexpressed upon exposure to inflammatory mediators. The protein is also highly expressed by tumor cells and contributes to their invasiveness and metastatic potential. CD87 is a multiligand receptor that operates as a key element in pathophysiological processes involving cell migration and tissue remodelling during inflammation and cancer metastasis. CD87 binds with high affinity the Ser-proteinase urokinase-type plasminogen activator (uPA) which, upon binding catalyzes the conversion of plasminogen into plasmin which activates various matrix metalloproteinase leading to a high potential for pericellular proteolysis. CD87 functions also as an adhesion molecule by binding vitronectin, thus contributing to leukocytic adherence. High-affinity binding of CD87 to both uPA and vitronectin requires the presence of domain 1 (D1). Yet, CD87 participates in cell adherence and migration also through two other routes, a physical association and functional interaction with various integrins and via an intrinsic chemotactic activity associated to the D1-D2 linker sequence.
 Product Categories/Family for anti-PLAUR antibody    Antibodies; Abs to Cancer Markers
 Applications Tested/Suitable for anti-PLAUR antibody   

Western Blot and Flow Cytometry
Other applications not tested.

 Application Notes for anti-PLAUR antibody    Flow Cytometry: 10ul/10e6 cells using mouse whole blood monocytes
Optimal dilutions to be determined by the researcher.
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 Testing Data of anti-PLAUR antibody    Mouse whole blood monocytes were stained with MBS632008 (filled histogram) or isotype control antibody
anti-PLAUR antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for PLAUR. It may not necessarily be applicable to this product.
 NCBI GI #    433901
 NCBI GeneID    5329
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 UniProt Primary Accession #    Q03405 [Other Products]
 UniProt Secondary Accession #    Q12876; Q15845; Q16887; Q6IB52; Q9BWT0; Q9NYC8; Q9UD69; Q9UEA6; Q9UM92; Q9UMV0; A8K409 [Other Products]
 UniProt Related Accession #    Q03405; Q6GY32; Q9UPI5 [Other Products]
 Molecular Weight    36,978 Da [Similar Products]
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 NCBI Official Full Name    urokinase plasminogen activator receptor
 NCBI Official Synonym Full Names    plasminogen activator, urokinase receptor
 NCBI Official Symbol    PLAUR [Similar Products]
 NCBI Official Synonym Symbols   
CD87; UPAR; URKR; U-PAR
[Similar Products]
 NCBI Protein Information    urokinase plasminogen activator surface receptor; monocyte activation antigen Mo3; u-plasminogen activator receptor form 2
 UniProt Protein Name    Urokinase plasminogen activator surface receptor
 UniProt Synonym Protein Names   
Monocyte activation antigen Mo3
 Protein Family    Urokinase plasminogen activator surface receptor
 UniProt Gene Name    PLAUR [Similar Products]
 UniProt Synonym Gene Names    MO3; UPAR [Similar Products]
 UniProt Entry Name    UPAR_HUMAN
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 NCBI Summary for PLAUR    This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq]
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 UniProt Comments for PLAUR    uPAR: Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. Monomer (Probable). Interacts with MRC2. Interacts (via the UPAR/Ly6 domains) with SRPX2. Expressed in neurons of the rolandic area of the brain. Expressed in the brain. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Motility/polarity/chemotaxis; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 19q13

Cellular Component: endoplasmic reticulum membrane; extrinsic to membrane; focal adhesion; endoplasmic reticulum lumen; integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function: protein domain specific binding; protein binding; U-plasminogen activator receptor activity; enzyme binding; receptor activity; receptor binding

Biological Process: fibrinolysis; cellular protein metabolic process; attachment of GPI anchor to protein; regulation of proteolysis; C-terminal protein lipidation; blood coagulation; post-translational protein modification; signal transduction; chemotaxis; cell motility
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 Research Articles on PLAUR    1. uPAR might guide/control the trafficking of mesenchymal stem cells to the injured vascular wall and their differentiation towards functional smooth muscle cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-PLAUR antibodyPathways associated with anti-PLAUR antibody
 Reference Product  PubMed Publications
 ITGAM antibody  >14 publications with PLAUR and ITGAM
 PLAU antibody  >10 publications with PLAUR and PLAU
 HCK antibody  >7 publications with PLAUR and HCK
 Products by Pathway  Pathway Diagram
 Arf6 Downstream Pathway antibodies  Arf6 Downstream Pathway Diagram
 Attachment Of GPI Anchor To UPAR Pathway antibodies  Attachment Of GPI Anchor To UPAR Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Dissolution Of Fibrin Clot Pathway antibodies  Dissolution Of Fibrin Clot Pathway Diagram
 FGF Signaling Pathway antibodies  FGF Signaling Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway antibodies  Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway Diagram
Diseases associated with anti-PLAUR antibodyOrgans/Tissues associated with anti-PLAUR antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >302 publications with PLAUR and Carcinoma
 Neoplasm Invasiveness Antibodies  >254 publications with PLAUR and Neoplasm Invasiveness
 Skin Diseases Antibodies  >173 publications with PLAUR and Skin Diseases
 Breast Neoplasms Antibodies  >158 publications with PLAUR and Breast Neoplasms
 Urogenital Neoplasms Antibodies  >139 publications with PLAUR and Urogenital Neoplasms
 Adenocarcinoma Antibodies  >116 publications with PLAUR and Adenocarcinoma
 Inflammation Antibodies  >102 publications with PLAUR and Inflammation
 Lung Diseases Antibodies  >85 publications with PLAUR and Lung Diseases
 Vascular Diseases Antibodies  >80 publications with PLAUR and Vascular Diseases
 Cardiovascular Diseases Antibodies  >74 publications with PLAUR and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >466 publications with PLAUR and Blood
 Vascular Antibodies  >287 publications with PLAUR and Vascular
 Lung Antibodies  >140 publications with PLAUR and Lung
 Muscle Antibodies  >95 publications with PLAUR and Muscle
 Liver Antibodies  >81 publications with PLAUR and Liver
 Brain Antibodies  >80 publications with PLAUR and Brain
 Embryonic Tissue Antibodies  >79 publications with PLAUR and Embryonic Tissue
 Bone Antibodies  >78 publications with PLAUR and Bone
 Prostate Antibodies  >64 publications with PLAUR and Prostate
 Skin Antibodies  >63 publications with PLAUR and Skin
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