NP_001161046.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
uroplakin-3a isoform 2
NCBI Official Synonym Full Names
uroplakin 3A
NCBI Protein Information
uroplakin-3a; uroplakin 3; uroplakin III
UniProt Protein Name
Uroplakin-3a
UniProt Synonym Protein Names
Uroplakin III; UPIII
UniProt Synonym Gene Names
UniProt Entry Name
UPK3A_HUMAN
NCBI Summary for UPK3A
This gene encodes a member of the uroplakin family, a group of transmembrane proteins that form complexes on the apical surface of the bladder epithelium. Mutations in this gene may be associated with renal adysplasia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009]
UniProt Comments for UPK3A
UPK3A: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence. Defects in UPK3A are a cause of renal adysplasia (RADYS); also known as renal agenesis or renal aplasia. Renal agenesis refers to the absence of one (unilateral) or both (bilateral) kidneys at birth. Bilateral renal agenesis belongs to a group of perinatally lethal renal diseases, including severe bilateral renal dysplasia, unilateral renal agenesis with contralateral dysplasia and severe obstructive uropathy. Belongs to the uroplakin-3 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 22q13.31
Cellular Component: endoplasmic reticulum membrane; apical plasma membrane; integral to membrane
Biological Process: epithelial cell differentiation; urinary bladder development; water transport; urea transport; cell morphogenesis; sodium ion homeostasis; kidney development; potassium ion homeostasis
Disease: Renal Hypodysplasia/aplasia 1
Research Articles on UPK3A
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Products associated with anti-UPK3A antibody
Diseases associated with anti-UPK3A antibody
Organs/Tissues associated with anti-UPK3A antibody
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