NP_001069.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
81,276 Da
NCBI Official Full Name
vascular cell adhesion protein 1 isoform a
NCBI Official Synonym Full Names
vascular cell adhesion molecule 1
NCBI Protein Information
vascular cell adhesion protein 1; CD106 antigen
UniProt Protein Name
Vascular cell adhesion protein 1
UniProt Synonym Protein Names
INCAM-100
UniProt Synonym Gene Names
UniProt Entry Name
VCAM1_HUMAN
NCBI Summary for V-CAM-1
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
UniProt Comments for V-CAM-1
Function: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.
Subunit structure: Binds to ECMV-D capsid proteins and acts as a receptor for this virus
By similarity.
Subcellular location: Membrane; Single-pass type I membrane protein.
Tissue specificity: Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue.
Induction: By cytokines (e.g. IL-1, TNF-alpha).
Domain: Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion. Ref.12
Post-translational modification: Sialoglycoprotein.
Sequence similarities: Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
Research Articles on V-CAM-1
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Products associated with anti-V-CAM-1 antibody
Pathways associated with anti-V-CAM-1 antibody
Organs/Tissues associated with anti-V-CAM-1 antibody
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