AAI48266.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
17,523 Da
NCBI Official Full Name
V-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)
NCBI Official Synonym Full Names
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K
NCBI Official Synonym Symbols
NCBI Protein Information
transcription factor MafK; basic-leucine zipper transcription factor MafK; erythroid transcription factor NF-E2 p18 subunit; nuclear factor erythroid-2, ubiquitous (p18); v-maf avian musculoaponeurotic fibrosarcoma oncogene family, protein K; v-maf musculoaponeurotic fibrosarcoma oncogene homolog K
UniProt Protein Name
Transcription factor MafK
UniProt Synonym Protein Names
Erythroid transcription factor NF-E2 p18 subunit
UniProt Entry Name
MAFK_HUMAN
NCBI Summary for MAFK
The developmentally regulated expression of the globin genes depends on upstream regulatory elements termed locus control regions (LCRs). LCRs are associated with powerful enhancer activity that is mediated by the transcription factor NFE2 (nuclear factor erythroid-2). NFE2 recognition sites are also present in the gene promoters of 2 heme biosynthetic enzymes, porphobilinogen deaminase (PBGD; MIM 609806) and ferrochelatase (FECH; MIM 612386). NFE2 DNA-binding activity consists of a heterodimer containing an 18-kD Maf protein (MafF, MafG (MIM 602020), or MafK) and p45 (MIM 601490). Both subunits are members of the activator protein-1 superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160). Maf homodimers suppress transcription at NFE2 sites.[supplied by OMIM, Nov 2008]
UniProt Comments for MAFK
MAFK: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Belongs to the bZIP family. Maf subfamily.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 7p22.3
Cellular Component: nucleoplasm
Molecular Function: transcription factor activity
Biological Process: nervous system development; transcription, DNA-dependent; regulation of transcription, DNA-dependent; blood coagulation
Research Articles on MAFK
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Products associated with anti-MAFK antibody
Pathways associated with anti-MAFK antibody
Diseases associated with anti-MAFK antibody
Organs/Tissues associated with anti-MAFK antibody
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