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anti-VAMP1 antibody :: Mouse VAMP 1,2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS604808 anti-VAMP1 antibody
Unit / Price
0.025 mL  /  $425 +1 FREE 8GB USB
0.1 mL  /  $610 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VAMP 1,2 (VAMP1), Monoclonal Antibody

 Also Known As   

VAMP 1,2 (Vesicle-Associated Membrane Protein, Synaptobrevin)

 Product Synonym Names    Anti -VAMP 1,2 (Vesicle-Associated Membrane Protein, Synaptobrevin)
 Product Gene Name   

anti-VAMP1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (6571403..6579843, complement). Location: 12p
 OMIM    185880
 3D Structure    ModBase 3D Structure for P23763
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 Clonality    Monoclonal
 Isotype    IgM
 Clone Number    4E240
 Host    Mouse
 Species Reactivity    Bovine, Hamster, Human, Mouse, Porcine, Rat, Xenopus
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 Specificity    Recognizes human VAMP on SDS-PAGE immunoblots at ~18kD. Recognizes the VAMP1 aa1-118 and the VAMP2 aa33-96-GST fusion proteins expressed in E. coli. No reactivity was seen with a ~18kD protein in mouse liver extracts. Species Crossreactivity: mouse, rat, bovine, hamster, porcine and Xenopus.
 Purity/Purification    Purified
Purified by ammonium sulfate pecipitation.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 0.1mM PMSF, 50% glycerol.
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 Immunogen    Immunoprecipitated synaptic vesicle-containing fractions from human brain homogenates.
 Positive Control    Rat Brain Tissue Extract
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-VAMP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-VAMP1 antibody

   Vesicle-associated membrane protein (VAMP), also known as synaptobrevin, is an 18kD integral membrane protein localized to the cytoplasmic surface of synaptic vesicle (2). VAMP consists of a proline-rich amino-terminal region, a highly conserved hydrophilic domain, followed by a transmembrane anchor and a carboxyl-terminal tail (3). Two VAMP homologs, VAMP1 and VAMP2, are differentially expressed in the nervous system (3). VAMP1 expression is localized to neurons involved in modulating overlapping patterns, whereas VAMP2 is found in neurons associated with autonomic, sensory and integrative functions. In non-neuronal tissues, VAMP1 is restricted to pancreas and kidney tubular cells, whereas VAMP2 is predominantly expressed in Langerhans islets and glomerular cells (4). Evidences for VAMP's involvement in vesicular transport and neurotransmission include the requirement of its yeast homologs, SNC 1 and 2, in targeting and fusion of Golgi- derived vesicles with the plasma membrane (5). VAMP is also the target of clostridial neurotoxins that block neurotransmitter release from presynaptic terminals (6). VAMP is a component of a 20S complex implicated in vesicle docking and fusion. The formation of 20S complex involves the interaction of VAMP with syntaxin through an ATP-dependent reaction modulated by synaptotagmin, SNAP-25, alpha-SNAP, and NSF (7).
 Product Categories/Family for anti-VAMP1 antibody    Antibodies; Abs to Membrane Proteins
 Applications Tested/Suitable for anti-VAMP1 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-VAMP1 antibody    Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot (Colorimetric): 1:4000
Immunohistochemistry: 1:50 on human neuroblastoma tissue.
Optimal dilutions to be determined by researcher.
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NCBI/Uniprot data below describe general gene information for VAMP1. It may not necessarily be applicable to this product.
 NCBI GI #    40549446
 NCBI GeneID    6843
 NCBI Accession #    NP_954740.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_199245.1 [Other Products]
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 UniProt Primary Accession #    P23763 [Other Products]
 UniProt Secondary Accession #    O75468; Q15857; Q6FG94; Q8IVC9; A8MVP3; D3DUR3 [Other Products]
 UniProt Related Accession #    P23763 [Other Products]
 Molecular Weight    12,902 Da [Similar Products]
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 NCBI Official Full Name    vesicle-associated membrane protein 1 isoform 2
 NCBI Official Synonym Full Names    vesicle-associated membrane protein 1 (synaptobrevin 1)
 NCBI Official Symbol    VAMP1 [Similar Products]
 NCBI Official Synonym Symbols   
SYB1; VAMP-1; DKFZp686H12131
[Similar Products]
 NCBI Protein Information    vesicle-associated membrane protein 1; synaptobrevin 1; synaptobrevin-1; OTTHUMP00000238453; OTTHUMP00000238454; OTTHUMP00000238455; OTTHUMP00000238560; OTTHUMP00000238561
 UniProt Protein Name    Vesicle-associated membrane protein 1
 UniProt Synonym Protein Names   
 Protein Family    Vesicle-associated membrane protein
 UniProt Gene Name    VAMP1 [Similar Products]
 UniProt Synonym Gene Names    SYB1 [Similar Products]
 UniProt Entry Name    VAMP1_HUMAN
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 NCBI Summary for VAMP1    Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple alternative splice variants that encode proteins with alternative carboxy ends have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq]
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 UniProt Comments for VAMP1    VAMP1: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Belongs to the synaptobrevin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 12p

Cellular Component: SNARE complex; synaptic vesicle; mitochondrial outer membrane; neuron projection; cell surface; synaptic vesicle membrane; integral to plasma membrane; cell junction; cytosol

Molecular Function: SNAP receptor activity; protein binding; SNARE binding

Biological Process: vesicle fusion; exocytosis; pathogenesis

Disease: Spastic Ataxia 1, Autosomal Dominant
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 Research Articles on VAMP1    1. multiple domains outside the R-SNARE of tomosyn are critical to the efficacy of inhibition by tomosyn on exocytotic secretion
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-VAMP1 antibodyPathways associated with anti-VAMP1 antibody
 Reference Product  PubMed Publications
 STX1A antibody  >5 publications with VAMP1 and STX1A
 SNAP23 antibody  >4 publications with VAMP1 and SNAP23
 STX1B antibody  >1 publications with VAMP1 and STX1B
 Products by Pathway  Pathway Diagram
 BoNT Light Chain Types B, D, And F Cleave VAMP/Synaptobrevin Pathway antibodies  BoNT Light Chain Types B, D, And F Cleave VAMP/Synaptobrevin Pathway Diagram
 Botulinum Neurotoxicity Pathway antibodies  Botulinum Neurotoxicity Pathway Diagram
 Proteolytic Cleavage Of SNARE Complex Proteins Pathway antibodies  Proteolytic Cleavage Of SNARE Complex Proteins Pathway Diagram
 SNARE Interactions In Vesicular Transport Pathway antibodies  SNARE Interactions In Vesicular Transport Pathway Diagram
 SNARE Interactions In Vesicular Transport Pathway antibodies  SNARE Interactions In Vesicular Transport Pathway Diagram
Diseases associated with anti-VAMP1 antibodyOrgans/Tissues associated with anti-VAMP1 antibody
 Disease Name  Pubmed Publications
 Schizophrenia Antibodies  >3 publications with VAMP1 and Schizophrenia
 Central Nervous System Diseases Antibodies  >3 publications with VAMP1 and Central Nervous System Diseases
 Wasting Syndrome Antibodies  >2 publications with VAMP1 and Wasting Syndrome
 Dementia Antibodies  >2 publications with VAMP1 and Dementia
 Mental Disorders Antibodies  >2 publications with VAMP1 and Mental Disorders
 Hypertension Antibodies  >1 publications with VAMP1 and Hypertension
 Pain Antibodies  >1 publications with VAMP1 and Pain
 Cognition Disorders Antibodies  >1 publications with VAMP1 and Cognition Disorders
 Inflammation Antibodies  >1 publications with VAMP1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >27 publications with VAMP1 and Nerve
 Brain Antibodies  >26 publications with VAMP1 and Brain
 Blood Antibodies  >6 publications with VAMP1 and Blood
 Heart Antibodies  >5 publications with VAMP1 and Heart
 Embryonic Tissue Antibodies  >2 publications with VAMP1 and Embryonic Tissue
 Bladder Antibodies  >2 publications with VAMP1 and Bladder
 Kidney Antibodies  >2 publications with VAMP1 and Kidney
 Intestine Antibodies  >1 publications with VAMP1 and Intestine
 Eye Antibodies  >1 publications with VAMP1 and Eye
 Uncharacterized Tissue Antibodies  >1 publications with VAMP1 and Uncharacterized Tissue
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