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anti-VCP antibody :: Mouse anti-Human VCP Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS245142
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VCP, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone 4G9] (IgG1) to Human VCP

 Product Synonym Names    Anti-VCP Antibody (clone 4G9) IHC-plus; VCP; 15S Mg(2+)-ATPase p97 subunit; ALS14; TER ATPase; TERA; Valosin containing protein; Yeast Cdc48p homolog; Valosin-containing protein; IBMPFD; p97; Human VCP
 Product Gene Name   

anti-VCP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 613954
 3D Structure    ModBase 3D Structure for P55072
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    4G9
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recombinant human valosin containing protein
 Purity/Purification    Affinity Purified
 Form/Format    Phosphate-buffered solution, pH 7.2, 0.09% sodium azide at 0.5 mg/ml. Sourced in TCS.
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Recombinant human VCP.
 Immunogen Type    Recombinant protein
 Immunogen    VCP antibody was raised against recombinant human VCP.
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 Preparation and Storage    Long term: -20 degree C; Short term: +4 degree C; Avoid freeze-thaw cycles.
 Other Notes    Small volumes of anti-VCP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-VCP antibody

   Valsolin Containing Protein (VCP) is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. VCP, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex.
 Applications Tested/Suitable for anti-VCP antibody   

Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-VCP antibody    IF, IHC-P (5 ug/ml), IP, WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-VCP antibody    Anti-VCP antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-VCP antibody Immunohistochemistry (IHC) (IHC) image
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 Immunocytochemistry (ICC) of anti-VCP antibody    Overnight nocodazole treated Hela cells stained with purified mouse monoclonal antibody against p97/VCP (clone 4G9), followed by Cy3 conjugated goat anti-mouse IgG and DAPI
anti-VCP antibody Immunocytochemistry (ICC) (ICC) image
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 Western Blot (WB) of anti-VCP antibody    Western blot of extracts from HeLa cells (Lane 1), Jurkat cells (Lane 2), MCF7 cells (Lane 3), or mouse splenocytes (Lane 4), using anti-p97/VCP, clone 4G9
anti-VCP antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for VCP. It may not necessarily be applicable to this product.
 NCBI GI #    6005942
 NCBI GeneID    7415
 NCBI Accession #    NP_009057.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007126.3 [Other Products]
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 UniProt Primary Accession #    P55072 [Other Products]
 UniProt Secondary Accession #    Q0V924; Q2TAI5; Q969G7; Q9UCD5; B2R5T8 [Other Products]
 UniProt Related Accession #    P55072 [Other Products]
 Molecular Weight    89,322 Da
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 NCBI Official Full Name    transitional endoplasmic reticulum ATPase
 NCBI Official Synonym Full Names    valosin containing protein
 NCBI Official Symbol    VCP [Similar Products]
 NCBI Official Synonym Symbols   
p97; TERA; ALS14; IBMPFD; HEL-220; IBMPFD1; HEL-S-70
[Similar Products]
 NCBI Protein Information    transitional endoplasmic reticulum ATPase; TER ATPase; yeast Cdc48p homolog; valosin-containing protein; 15S Mg(2+)-ATPase p97 subunit; epididymis luminal protein 220; epididymis secretory protein Li 70
 UniProt Protein Name    Transitional endoplasmic reticulum ATPase
 UniProt Synonym Protein Names   
15S Mg(2+)-ATPase p97 subunit; Valosin-containing protein; VCP
 Protein Family    VCP-like ATPase
 UniProt Gene Name    VCP [Similar Products]
 UniProt Synonym Gene Names    TER ATPase; VCP [Similar Products]
 UniProt Entry Name    TERA_HUMAN
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 NCBI Summary for VCP    The protein encoded by this gene is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. This protein, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. It has been implicated in a number of cellular events that are regulated during mitosis, including homotypic membrane fusion, spindle pole body function, and ubiquitin-dependent protein degradation. [provided by RefSeq, Jul 2008]
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 UniProt Comments for VCP    VCP: valosin-containing protein (VCP) is a member of a family that includes putative ATP-binding proteins involved in vesicle transport and fusion, 26S proteasome function, and assembly of peroxisomes. VCP, as a structural protein, is associated with clathrin, and heat-shock protein Hsc70, to form a complex. Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope and of the transitional endoplasmic reticulum (tER). Regulates NFKappaB pathway, which is important for metastasis of osteosarcoma. Tyrosine phosphorylation regulates its cell cycle-dependent nuclear localization.

Protein type: DNA repair, damage; Endoplasmic reticulum; Chaperone; EC 3.6.4.6; Hydrolase

Chromosomal Location of Human Ortholog: 9p13.3

Cellular Component: proteasome complex; nucleoplasm; endoplasmic reticulum membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; lipid particle; cytosol; nucleus

Molecular Function: protein domain specific binding; identical protein binding; protein binding; ATPase activity; protein complex binding; polyubiquitin binding; ADP binding; protein phosphatase binding; lipid binding; ATP binding; receptor binding

Biological Process: caspase activation; proteasomal ubiquitin-dependent protein catabolic process; ER-associated protein catabolic process; ER to Golgi vesicle-mediated transport; unfolded protein response; protein ubiquitination; DNA repair; regulation of apoptosis; retrograde protein transport, ER to cytosol; establishment of protein localization; bypass DNA synthesis; positive regulation of protein complex assembly; double-strand break repair; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein catabolic process; protein amino acid N-linked glycosylation via asparagine; response to DNA damage stimulus; protein homooligomerization

Disease: Inclusion Body Myopathy With Early-onset Paget Disease With Or Without Frontotemporal Dementia 1; Amyotrophic Lateral Sclerosis 14, With Or Without Frontotemporal Dementia
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 Research Articles on VCP    1. findings uncovered an important role of USP7 in regulating NER via deubiquitinating XPC and by preventing its VCP/p97-regulated proteolysis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-VCP antibodyPathways associated with anti-VCP antibody
 Reference Product  PubMed Publications
 UFD1L antibody  >22 publications with VCP and UFD1L
 AMFR antibody  >16 publications with VCP and AMFR
 FAF1 antibody  >10 publications with VCP and FAF1
 ATXN3 antibody  >8 publications with VCP and ATXN3
 UBE4B antibody  >7 publications with VCP and UBE4B
 SYVN1 antibody  >7 publications with VCP and SYVN1
 DERL1 antibody  >7 publications with VCP and DERL1
 UBC antibody  >1 publications with VCP and UBC
 NSFL1C antibody  >1 publications with VCP and NSFL1C
 Products by Pathway  Pathway Diagram
 Cellular Response To Heat Stress Pathway antibodies  Cellular Response To Heat Stress Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 HRD1/SEL1 ERAD Complex Pathway antibodies  HRD1/SEL1 ERAD Complex Pathway Diagram
 HRD1/SEL1 ERAD Complex Pathway antibodies  HRD1/SEL1 ERAD Complex Pathway Diagram
 HSF1 Activation Pathway antibodies  HSF1 Activation Pathway Diagram
 Hedgehog Ligand Biogenesis Pathway antibodies  Hedgehog Ligand Biogenesis Pathway Diagram
 Hh Ligand Biogenesis Disease Pathway antibodies  Hh Ligand Biogenesis Disease Pathway Diagram
 IL-9 Signaling Pathway antibodies  IL-9 Signaling Pathway Diagram
 Legionellosis Pathway antibodies  Legionellosis Pathway Diagram
Diseases associated with anti-VCP antibodyOrgans/Tissues associated with anti-VCP antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >46 publications with VCP and Carcinoma
 Immune System Diseases Antibodies  >42 publications with VCP and Immune System Diseases
 Disease Models, Animal Antibodies  >38 publications with VCP and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >38 publications with VCP and Cardiovascular Diseases
 Atrophy Antibodies  >28 publications with VCP and Atrophy
 Inflammation Antibodies  >27 publications with VCP and Inflammation
 Heart Diseases Antibodies  >22 publications with VCP and Heart Diseases
 Necrosis Antibodies  >16 publications with VCP and Necrosis
 Lung Neoplasms Antibodies  >16 publications with VCP and Lung Neoplasms
 Adenocarcinoma Antibodies  >13 publications with VCP and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >134 publications with VCP and Bone
 Brain Antibodies  >117 publications with VCP and Brain
 Blood Antibodies  >112 publications with VCP and Blood
 Muscle Antibodies  >105 publications with VCP and Muscle
 Nerve Antibodies  >93 publications with VCP and Nerve
 Vascular Antibodies  >38 publications with VCP and Vascular
 Lung Antibodies  >33 publications with VCP and Lung
 Heart Antibodies  >32 publications with VCP and Heart
 Liver Antibodies  >31 publications with VCP and Liver
 Skin Antibodies  >27 publications with VCP and Skin
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