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anti-VEGF antibody :: Mouse anti-Rabbit VEGF Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS530756 anti-VEGF antibody
Unit / Price
0.2 mg  /  $780 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VEGF, Monoclonal Antibody

 Also Known As   

VEGF antibody (BSA/Azide Free)

 Product Synonym Names    Monoclonal VEGF; Anti-VEGF; Vascular Endothelial Growth Factor; VPF; VEGF; Anti VEGF; Glioma-derived endothelial cell mitogen; Folliculostellate cell-derived growth factor
 Product Gene Name   

anti-VEGF antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    192240
 3D Structure    ModBase 3D Structure for P15692
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 Clonality    Monoclonal
 Isotype    IgG1 kappa
 Clone Number    JH121
 Host    Mouse
 Species Reactivity    Rabbit
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 Specificity    Human
 Purity/Purification    VEGF antibody (BSA/Azide Free) was purified by Protein G chromatography.
 Form/Format    Antibody purified from ascites and supplied in 10mM PBS, pH 7.4
 Concentration    1.0 mg/ml (lot specific)
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 Biological Significance    VEGF (vascular endothelial growth factor) is a homodimeric, disulfide-linked glycoprotein involved in angiogenesis which promotes tumor progression and metastasis. It exhibits potent mitogenic and permeability inducing properties specific for the vascular endothelium. Of the four isoforms of VEGF, the smaller two, VEGF165 and VEGF121, are secreted proteins and act as diffusible agents, whereas the larger two (VEGF189 and VEGF206) remain cell associated.
 Immunogen    VEGF antibody (BSA/Azide Free) was raised in mouse using recombinant human VEGF121 as the immunogen.
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 Preparation and Storage    Store at 4 degree C.
 Other Notes    Small volumes of anti-VEGF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-VEGF antibody

   Mouse monoclonal VEGF antibody (BSA/Azide Free)
 Product Categories/Family for anti-VEGF antibody    Cytokines & Growth Factors
 Applications Tested/Suitable for anti-VEGF antibody   

Neutralization

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NCBI/Uniprot data below describe general gene information for VEGF. It may not necessarily be applicable to this product.
 NCBI GI #    181971
 NCBI GeneID    7422
 NCBI Accession #    AAA35789.1 [Other Products]
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 UniProt Primary Accession #    P15692 [Other Products]
 UniProt Secondary Accession #    O60720; O75875; Q074Z4; Q16889; B5BU86; H0Y2S8; H0Y407; H0Y414; H0Y462; H0Y8N2; H3BLW7 [Other Products]
 UniProt Related Accession #    P15692 [Other Products]
 Molecular Weight    19-22 kDa (predicted detection band MW)
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 NCBI Official Full Name    vascular endothelial growth factor
 NCBI Official Synonym Full Names    vascular endothelial growth factor A
 NCBI Official Symbol    VEGFA [Similar Products]
 NCBI Official Synonym Symbols   
VPF; VEGF; MVCD1
[Similar Products]
 NCBI Protein Information    vascular endothelial growth factor A
 UniProt Protein Name    Vascular endothelial growth factor A
 UniProt Synonym Protein Names   
Vascular permeability factor; VPF
 Protein Family    VEGF coregulated chemokine
 UniProt Gene Name    VEGFA [Similar Products]
 UniProt Synonym Gene Names    VEGF; VEGF-A; VPF [Similar Products]
 UniProt Entry Name    VEGFA_HUMAN
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 NCBI Summary for VEGF    This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for VEGF    Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth.
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 Research Articles on VEGF    1. increased peritoneal expression of connective tissue growth factor (CCN2), transforming growth factor-beta1, and vascular endothelial growth factor in encapsulating peritoneal sclerosis encapsulating peritoneal sclerosis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-VEGF antibodyPathways associated with anti-VEGF antibody
 Reference Product  PubMed Publications
 HIF1A antibody  >562 publications with VEGF and HIF1A
 KDR antibody  >277 publications with VEGF and KDR
 FLT1 antibody  >183 publications with VEGF and FLT1
 TGFB1 antibody  >154 publications with VEGF and TGFB1
 MMP9 antibody  >103 publications with VEGF and MMP9
 SRC antibody  >63 publications with VEGF and SRC
 NRP1 antibody  >57 publications with VEGF and NRP1
 VWF antibody  >50 publications with VEGF and VWF
 IGF1 antibody  >30 publications with VEGF and IGF1
 PGF antibody  >26 publications with VEGF and PGF
 Products by Pathway  Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Cellular Response To Hypoxia Pathway antibodies  Cellular Response To Hypoxia Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPH-Ephrin Signaling Pathway antibodies  EPH-Ephrin Signaling Pathway Diagram
Diseases associated with anti-VEGF antibodyOrgans/Tissues associated with anti-VEGF antibody
 Disease Name  Pubmed Publications
 Neovascularization, Pathologic Antibodies  >1970 publications with VEGF and Neovascularization, Pathologic
 Retinal Diseases Antibodies  >1502 publications with VEGF and Retinal Diseases
 Macular Degeneration Antibodies  >1025 publications with VEGF and Macular Degeneration
 Neoplasm Metastasis Antibodies  >507 publications with VEGF and Neoplasm Metastasis
 Choroidal Neovascularization Antibodies  >497 publications with VEGF and Choroidal Neovascularization
 Inflammation Antibodies  >480 publications with VEGF and Inflammation
 Diabetic Retinopathy Antibodies  >473 publications with VEGF and Diabetic Retinopathy
 Lung Diseases Antibodies  >413 publications with VEGF and Lung Diseases
 Macular Edema Antibodies  >364 publications with VEGF and Macular Edema
 Heart Diseases Antibodies  >280 publications with VEGF and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >8090 publications with VEGF and Vascular
 Blood Antibodies  >3064 publications with VEGF and Blood
 Eye Antibodies  >1462 publications with VEGF and Eye
 Bone Antibodies  >539 publications with VEGF and Bone
 Lung Antibodies  >534 publications with VEGF and Lung
 Muscle Antibodies  >466 publications with VEGF and Muscle
 Embryonic Tissue Antibodies  >413 publications with VEGF and Embryonic Tissue
 Heart Antibodies  >377 publications with VEGF and Heart
 Liver Antibodies  >358 publications with VEGF and Liver
 Kidney Antibodies  >343 publications with VEGF and Kidney
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