NP_647480
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
64,991 Da
NCBI Official Full Name
vesicular glutamate transporter 3 isoform 1
NCBI Official Synonym Full Names
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
NCBI Protein Information
vesicular glutamate transporter 3; solute carrier family 17 member 8
UniProt Protein Name
Vesicular glutamate transporter 3
UniProt Synonym Protein Names
Solute carrier family 17 member 8
UniProt Synonym Gene Names
UniProt Entry Name
VGLU3_HUMAN
NCBI Summary for VGLUT3
This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft. Mutations in this gene are the cause of autosomal-dominant nonsyndromic type 25 deafness. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
UniProt Comments for VGLUT3
Function: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Ref.1
Subcellular location: Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane
By similarity. Membrane; Multi-pass membrane protein
Potential. Cell junction › synapse › synaptosome
By similarity.
Tissue specificity: Expressed in amygdala, cerebellum, hippocampus, medulla, spinal cord and thalamus. Ref.1
Involvement in disease: Deafness, autosomal dominant, 25 (DFNA25) [MIM:605583]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA25 expression is variable in terms of onset and rate of progression, with an age-dependent penetrance resembling an early-onset presbycusis, or senile deafness, a progressive bilateral loss of hearing that occurs in the aged.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.5
Sequence similarities: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
Research Articles on VGLUT3
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Pathways associated with anti-VGLUT3 antibody
Diseases associated with anti-VGLUT3 antibody
Organs/Tissues associated with anti-VGLUT3 antibody
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