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anti-VGLUT3 antibody :: Mouse anti-Human VGLUT3 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS680020 anti-VGLUT3 antibody
Unit / Price
0.1 mg  /  $380 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VGLUT3, Monoclonal Antibody

 Also Known As   

mAb to VGLUT3

 Product Synonym Names    VGLUT3 Monoclonal Antibody; Vesicular glutamate transporter 3; SLC17A8
 Product Gene Name   

anti-VGLUT3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (100750857..100815837). Location: 12q23.1
 OMIM    605583
 3D Structure    ModBase 3D Structure for Q8NDX2
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    3D11
 Host    Mouse
 Species Reactivity    Human
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 Specificity    VGLUT3 (Human VGLUT3)
 Form/Format    Affinity Purified
 Concentration    1 mg/ml in PBS pH 7.2 (lot specific)
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 Immunogen    Recombinant Protein
 Reconstitution    Add 100ul of ddH2O to the tube containing antibody and mix to dissolve
 Product Note    *Cross reactivity and Applications data is per published literature and/or unpublished data.
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 Preparation and Storage    Store at -20 degree C lyophilized, 4 degree C reconstituted
 Other Notes    Small volumes of anti-VGLUT3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-VGLUT3 antibody

   VGLUT3 is a neural transport protein
VGLUT3 is a 65 kDa Neural transport protein
65 kDa Neural transport protein

Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
 Applications Tested/Suitable for anti-VGLUT3 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-VGLUT3 antibody    ELISA (EIA): Positive
Western Blot: Yes - dilute at 1:1000
Immuno-isolation of Vesicles: Yes
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NCBI/Uniprot data below describe general gene information for VGLUT3. It may not necessarily be applicable to this product.
 NCBI GI #    21322234
 NCBI GeneID    246213
 NCBI Accession #    NP_647480 [Other Products]
 NCBI GenBank Nucleotide #    NM_139319.2 [Other Products]
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 UniProt Primary Accession #    Q8NDX2 [Other Products]
 UniProt Secondary Accession #    Q17RQ8; B3KXZ6; B7ZKV4 [Other Products]
 UniProt Related Accession #    Q8NDX2 [Other Products]
 Molecular Weight    64,991 Da
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 NCBI Official Full Name    vesicular glutamate transporter 3 isoform 1
 NCBI Official Synonym Full Names    solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8
 NCBI Official Symbol    SLC17A8 [Similar Products]
 NCBI Official Synonym Symbols   
DFNA25; VGLUT3
[Similar Products]
 NCBI Protein Information    vesicular glutamate transporter 3; solute carrier family 17 member 8
 UniProt Protein Name    Vesicular glutamate transporter 3
 UniProt Synonym Protein Names   
Solute carrier family 17 member 8
 UniProt Gene Name    SLC17A8 [Similar Products]
 UniProt Synonym Gene Names    VGLUT3; VGluT3 [Similar Products]
 UniProt Entry Name    VGLU3_HUMAN
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 NCBI Summary for VGLUT3    This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft. Mutations in this gene are the cause of autosomal-dominant nonsyndromic type 25 deafness. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
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 UniProt Comments for VGLUT3    Function: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Ref.1

Subcellular location: Cytoplasmic vesicle › secretory vesicle › synaptic vesicle membrane

By similarity. Membrane; Multi-pass membrane protein

Potential. Cell junction › synapse › synaptosome

By similarity.

Tissue specificity: Expressed in amygdala, cerebellum, hippocampus, medulla, spinal cord and thalamus. Ref.1

Involvement in disease: Deafness, autosomal dominant, 25 (DFNA25) [MIM:605583]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA25 expression is variable in terms of onset and rate of progression, with an age-dependent penetrance resembling an early-onset presbycusis, or senile deafness, a progressive bilateral loss of hearing that occurs in the aged.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.5

Sequence similarities: Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
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 Research Articles on VGLUT3    1. SLC17A8 encodes vesicular glutamate transporter-3, VGLUT3 and its impairment has a role in nonsyndromic deafness DFNA25 and inner hair cell dysfunction
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-VGLUT3 antibodyDiseases associated with anti-VGLUT3 antibody
 Products by Pathway  Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Glutamatergic Synapse Pathway antibodies  Glutamatergic Synapse Pathway Diagram
 Nicotine Addiction Pathway antibodies  Nicotine Addiction Pathway Diagram
 Nicotine Addiction Pathway antibodies  Nicotine Addiction Pathway Diagram
 Organic Anion Transporters Pathway antibodies  Organic Anion Transporters Pathway Diagram
 Retrograde Endocannabinoid Signaling Pathway antibodies  Retrograde Endocannabinoid Signaling Pathway Diagram
 Retrograde Endocannabinoid Signaling Pathway antibodies  Retrograde Endocannabinoid Signaling Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Synaptic Vesicle Pathway antibodies  Synaptic Vesicle Pathway Diagram
 Synaptic Vesicle Cycle Pathway antibodies  Synaptic Vesicle Cycle Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with VGLUT3 and Nervous System Diseases
 Brain Diseases Antibodies  >1 publications with VGLUT3 and Brain Diseases
 Disease Models, Animal Antibodies  >1 publications with VGLUT3 and Disease Models, Animal
 Inflammation Antibodies  >1 publications with VGLUT3 and Inflammation
Organs/Tissues associated with anti-VGLUT3 antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1 publications with VGLUT3 and Bone
 Intestine Antibodies  >1 publications with VGLUT3 and Intestine
 Testis Antibodies  >1 publications with VGLUT3 and Testis
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