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anti-VLDLR antibody :: Mouse anti-Human VLDL receptor, clone 1H10 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS135058 anti-VLDLR antibody
Unit / Price
1 mg  /  $535 +1 FREE 8GB USB
10 mg  /  $3,810 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VLDL receptor, clone 1H10 (VLDLR), Monoclonal Antibody

★Popular Item★
 Also Known As   

Anti Human VLDL receptor, clone 1H10

 Product Gene Name   

anti-VLDLR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 9; NC_000009.11 (2621793..2654485). Location: 9p24
 OMIM    192977
 3D Structure    ModBase 3D Structure for P98155
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 Clonality    Monoclonal
 Isotype    IgG1 kappa
 Clone Number    1H10
 Host    Mouse
 Species Reactivity    Human
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 Purity/Purification    IgG fraction
 Form/Format    Frozen liquid
 Concentration    4.74 mg/ml (lot specific)
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 Source    Hybridoma cell culture.
 Immunogen    Recombinant fragment of soluble VLDL receptor containing ligand binding repeats 1-8 (sVLDLr1-8).
 Target    Recognises the C-terminus of VLDL receptor ligand binding domain (191-355)
 Target Molecular Weight    85,000
 Antigen    Recombinant fragment of soluble VLDL receptor containing ligand repeats 1-8 (sVLDLr1-8).
 Buffer    0.05M Sodium Phosphate; 0.1M NaCl; 1mM EDTA; pH 6.6
 Extinction Coefficient    1.36
 Aliquot    1 x 1.0mg
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 Preparation and Storage    Store at -70C.
Shelf Life: 5 years from delivery
Shipping: Ships in Blue Ice.
 Other Notes    Small volumes of anti-VLDLR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-VLDLR antibody

   Monoclonal antibody produced in mouse. Useful for ELISA and western blot under non-reducing conditions. Binds to an epitope on the C-terminus of VLDL receptor ligand binding domain (amino acids 191-355, UniProtKB: locus VLDLR_HUMAN, accession P98155) and blocks apoE4 binding. Purified by immobilized Protein A. IgG1 class.
 Product Categories/Family for anti-VLDLR antibody    Receptor Associated Protein (RAP); Monoclonal Antibodies to Human VLDL Receptor
 Applications Tested/Suitable for anti-VLDLR antibody   

ELISA (EIA), Western Blot (WB), BL

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NCBI/Uniprot data below describe general gene information for VLDLR. It may not necessarily be applicable to this product.
 NCBI GI #    65301164
 NCBI GeneID    7436
 NCBI Accession #    NP_001018066.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001018056.1 [Other Products]
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 UniProt Primary Accession #    P98155 [Other Products]
 UniProt Secondary Accession #    Q5VVF6; B2RMZ7; D3DRH6 [Other Products]
 UniProt Related Accession #    P98155 [Other Products]
 Molecular Weight    160,000
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 NCBI Official Full Name    very low-density lipoprotein receptor isoform b
 NCBI Official Synonym Full Names    very low density lipoprotein receptor
 NCBI Official Symbol    VLDLR [Similar Products]
 NCBI Official Synonym Symbols   
CARMQ1; CHRMQ1; VLDLRCH
[Similar Products]
 NCBI Protein Information    very low-density lipoprotein receptor; VLDL-R; VLDL receptor
 UniProt Protein Name    Very low-density lipoprotein receptor
 Protein Family    Very low-density lipoprotein receptor
 UniProt Gene Name    VLDLR [Similar Products]
 UniProt Synonym Gene Names    VLDL receptor; VLDL-R [Similar Products]
 UniProt Entry Name    VLDLR_HUMAN
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 NCBI Summary for VLDLR    The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009]
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 UniProt Comments for VLDLR    VLDLR: Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation. Defects in VLDLR are the cause of cerebellar ataxia mental retardation and dysequilibrium syndrome type 1 (CMARQ1); also known as dysequilibrium syndrome (DES) or non- progressive cerebellar disorder with mental retardation. CMARQ1 is a congenital, non-progressive cerebellar ataxia associated with disturbed equilibrium, delayed ambulation, mental retardation and cerebellar hypoplasia. Additional features include short stature, strabismus, pes planus and, rarely, seizures. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 9p24

Cellular Component: membrane; plasma membrane; integral to membrane; coated pit; receptor complex

Molecular Function: low-density lipoprotein receptor activity; very-low-density lipoprotein receptor activity; very-low-density lipoprotein binding; protein binding; apolipoprotein binding; calcium ion binding; glycoprotein binding; calcium-dependent protein binding

Biological Process: cholesterol metabolic process; nervous system development; receptor-mediated endocytosis; positive regulation of protein kinase activity; ventral spinal cord development; negative regulation of transcription from RNA polymerase II promoter; lipid transport; signal transduction; memory

Disease: Cerebellar Ataxia, Mental Retardation, And Dysequilibrium Syndrome 1
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 Research Articles on VLDLR    1. The pathological increase of HIF-1alpha in clear-cell renal cell carcinoma cells upregulates VLDL-R, which mediates increased uptake and accumulation of lipids.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-VLDLR antibodyPathways associated with anti-VLDLR antibody
 Reference Product  PubMed Publications
 DAB1 antibody  >62 publications with VLDLR and DAB1
 APOE antibody  >44 publications with VLDLR and APOE
 RELN antibody  >19 publications with VLDLR and RELN
 LPL antibody  >15 publications with VLDLR and LPL
 SNX17 antibody  >1 publications with VLDLR and SNX17
 LRPAP1 antibody  >1 publications with VLDLR and LRPAP1
 Products by Pathway  Pathway Diagram
 Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway antibodies  Lissencephaly Gene (LIS1) In Neuronal Migration And Development Pathway Diagram
 Reelin Signaling Pathway antibodies  Reelin Signaling Pathway Diagram
Diseases associated with anti-VLDLR antibodyOrgans/Tissues associated with anti-VLDLR antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >37 publications with VLDLR and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >25 publications with VLDLR and Cardiovascular Diseases
 Brain Diseases Antibodies  >24 publications with VLDLR and Brain Diseases
 Neoplasms Antibodies  >16 publications with VLDLR and Neoplasms
 Disease Models, Animal Antibodies  >15 publications with VLDLR and Disease Models, Animal
 Fatty Liver Antibodies  >8 publications with VLDLR and Fatty Liver
 Obesity Antibodies  >8 publications with VLDLR and Obesity
 Adenocarcinoma Antibodies  >6 publications with VLDLR and Adenocarcinoma
 Dysequilibrium syndrome Antibodies  >6 publications with VLDLR and Dysequilibrium syndrome
 Inflammation Antibodies  >5 publications with VLDLR and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >111 publications with VLDLR and Brain
 Blood Antibodies  >51 publications with VLDLR and Blood
 Vascular Antibodies  >36 publications with VLDLR and Vascular
 Liver Antibodies  >31 publications with VLDLR and Liver
 Embryonic Tissue Antibodies  >30 publications with VLDLR and Embryonic Tissue
 Muscle Antibodies  >30 publications with VLDLR and Muscle
 Adipose Tissue Antibodies  >22 publications with VLDLR and Adipose Tissue
 Heart Antibodies  >21 publications with VLDLR and Heart
 Ovary Antibodies  >18 publications with VLDLR and Ovary
 Eye Antibodies  >14 publications with VLDLR and Eye
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