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anti-VNN2  antibody :: Rabbit anti-Human VNN2  Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2544280 anti-VNN2  antibody
Unit / Price
0.06 mL  /  $215 +1 FREE 8GB USB
0.12 mL  /  $330 +1 FREE 8GB USB
0.2 mL  /  $500 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

VNN2 , Monoclonal Antibody

 Also Known As   

Rabbit anti Human VNN2  Monoclonal Antibody

 Product Gene Name   

anti-VNN2  antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AJ132100 mRNA
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 Clonality    Monoclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Immunogen    Recombinant Human VNN2/Vanin-2 protein
 Buffer    This antibody was obtained from a rabbit immunized with purified, recombinant Human VNN2/Vanin-2 (rh VNN2/Vanin-2; NP_004656.2; Met 1-Ser 492).
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 Preparation and Storage    This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -70 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-VNN2  antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-VNN2  antibody

   Vascular non-inflammatory molecule 2, also known as glycosyl-phosphatidyl inositol-anchored protein GPI-80, Vanin-2, Protein FOAP-4 and VNN2, is a cell membrane protein which belongs to the CN hydrolase family and Vanin subfamily. VNN2 is widely expressed with higher expression in spleen and blood. VNN2 is a member of the vanin family of proteins which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. VNN2 is an amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. It is involved in the thymus homing of bone marrow cells. VNN2 plays a role in transendothelial migration of neutrophils and may regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil.
 Applications Tested/Suitable for anti-VNN2  antibody   

ELISA (EIA)

 Application Notes for anti-VNN2  antibody    ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human VNN2. The detection limit for Human VNN2 is approximately 0. 078 ng/well.
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NCBI/Uniprot data below describe general gene information for VNN2 . It may not necessarily be applicable to this product.
 NCBI GI #    334278906
 NCBI GeneID    8875
 NCBI GenBank Nucleotide #    NM_001242350.2 [Other Products]
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 UniProt Secondary Accession #    Q2XUN1; Q9UJF3; A0AUZ3; A6NDY1; A8K4E3; A8K7W0; B2DFZ0; B2DFZ1; B2DFZ2; B2DFZ3; F6XL73 [Other Products]
 UniProt Related Accession #    O95498 [Other Products]
 Molecular Weight    52,844 Da
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 NCBI Official Full Name    vascular non-inflammatory molecule 2 isoform 3
 NCBI Official Synonym Full Names    vanin 2
 NCBI Official Symbol    VNN2 [Similar Products]
 NCBI Official Synonym Symbols   
FOAP-4; GPI-80
[Similar Products]
 NCBI Protein Information    vascular non-inflammatory molecule 2
 UniProt Protein Name    Vascular non-inflammatory molecule 2
 UniProt Synonym Protein Names   
Glycosylphosphatidyl inositol-anchored protein GPI-80; Protein FOAP-4
 UniProt Gene Name    VNN2 [Similar Products]
 UniProt Synonym Gene Names    Vanin-2 [Similar Products]
 UniProt Entry Name    VNN2_HUMAN
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 NCBI Summary for VNN2     This gene product is a member of the Vanin family of proteins that share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. The encoded protein is a GPI-anchored cell surface molecule that plays a role in transendothelial migration of neutrophils. This gene lies in close proximity to, and in same transcriptional orientation as two other vanin genes on chromosome 6q23-q24. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]
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 UniProt Comments for VNN2     VNN2: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Involved in the thymus homing of bone marrow cells. May regulate beta-2 integrin-mediated cell adhesion, migration and motility of neutrophil. Belongs to the CN hydrolase family. BTD/VNN subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.5.1.92; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 6q23-q24

Molecular Function: pantetheine hydrolase activity

Biological Process: biotin metabolic process; cell motility; central nervous system development; pantothenate metabolic process
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 Research Articles on VNN2     1. GPI-80 defines a subpopulation of human fetal liver hematopoietic stem/progenitor cells (HSPCs) with self-renewal ability.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-VNN2  antibodyDiseases associated with anti-VNN2  antibody
 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram
 Metabolism Of Water-soluble Vitamins And Cofactors Pathway antibodies  Metabolism Of Water-soluble Vitamins And Cofactors Pathway Diagram
 Pantothenate And CoA Biosynthesis Pathway antibodies  Pantothenate And CoA Biosynthesis Pathway Diagram
 Pantothenate And CoA Biosynthesis Pathway antibodies  Pantothenate And CoA Biosynthesis Pathway Diagram
 Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway antibodies  Post-translational Modification: Synthesis Of GPI-anchored Proteins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Vitamin B5 (pantothenate) Metabolism Pathway antibodies  Vitamin B5 (pantothenate) Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >8 publications with VNN2  and Inflammation
 Chromosome Aberrations Antibodies  >2 publications with VNN2  and Chromosome Aberrations
 Cardiovascular Diseases Antibodies  >2 publications with VNN2  and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >1 publications with VNN2  and Disease Models, Animal
 Vascular Diseases Antibodies  >1 publications with VNN2  and Vascular Diseases
 Neoplasm Metastasis Antibodies  >1 publications with VNN2  and Neoplasm Metastasis
 Anemia Antibodies  >1 publications with VNN2  and Anemia
 Necrosis Antibodies  >1 publications with VNN2  and Necrosis
 Psoriasis Antibodies  >1 publications with VNN2  and Psoriasis
 Myocardial Ischemia Antibodies  >1 publications with VNN2  and Myocardial Ischemia
Organs/Tissues associated with anti-VNN2  antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >23 publications with VNN2  and Blood
 Thymus Antibodies  >4 publications with VNN2  and Thymus
 Lung Antibodies  >2 publications with VNN2  and Lung
 Kidney Antibodies  >1 publications with VNN2  and Kidney
 Heart Antibodies  >1 publications with VNN2  and Heart
 Connective Tissue Antibodies  >1 publications with VNN2  and Connective Tissue
 Lymph Antibodies  >1 publications with VNN2  and Lymph
 Skin Antibodies  >1 publications with VNN2  and Skin
 Lymph Node Antibodies  >1 publications with VNN2  and Lymph Node
 Uncharacterized Tissue Antibodies  >1 publications with VNN2  and Uncharacterized Tissue
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