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anti-VCAM1 antibody :: Mouse anti-Rabbit Vascular Cell Adhesion Molecule 1 (VCAM1) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2001285 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Western Blot (WB)
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $245 +1 FREE 8GB USB
0.2 mg  /  $330 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Vascular Cell Adhesion Molecule 1 (VCAM1), Monoclonal Antibody

 Also Known As   

Monoclonal Antibody to Vascular Cell Adhesion Molecule 1 (VCAM1)

 Product Gene Name   

anti-VCAM1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    The target protein is fused with two N-terminal Tags, His-tag and S-tag and its sequence is listed below.
MHHHHHHSSG LVPRGSGMKE TAAAKFERQH MDSPDLGTDD DDKAMADIGS EF- IE LSGPPVNGRP VTVSCKVPNV YPFDXLEIEL LKGETMMKNK EFLEEEDKKS LETKSLEMTF IPTMEDTGKV LVCQAKLHID EMEFEPKQRQ STQPLFVNVA PRDIAVWVSP SSIVEEGRSV NMTCSSYGLP APKILWSRQL KNGDLQPLSE NTTLALISTK LEDSGIYVCE GINLAGKSRK EVELVIQVAP KDIQLTAFPS KSVKEGDTVI ISCTCGNVPE TWIILKKKAE TGDTVLKSID
 Chromosome Location    Chromosome: 1; NC_000001.10 (101185196..101204601). Location: 1p32-p31
 OMIM    192225
 3D Structure    ModBase 3D Structure for P19320
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 Clonality    Monoclonal
 Isotype    IgG
 Host    Mouse
 Species Reactivity    Rabbit
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 Specificity    The antibody is a mouse monoclonal antibody raised against VCAM1. It has been selected for its ability to recognize VCAM1 in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    500ug/ml (lot specific)
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 Immunogen    Recombinant VCAM1 (Ile409~Thr682) expressed in E.coli.
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-VCAM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-VCAM1 antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-VCAM1 antibody    Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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 Western Blot (WB) of anti-VCAM1 antibody    anti-VCAM1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for VCAM1. It may not necessarily be applicable to this product.
 NCBI GI #    179886
 NCBI GeneID    7412
 NCBI Accession #    AAA51917.1 [Other Products]
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 UniProt Primary Accession #    P19320 [Other Products]
 UniProt Secondary Accession #    Q6NUP8; A8K6R7; B4DKS4; E9PDD1 [Other Products]
 UniProt Related Accession #    P19320 [Other Products]
 Molecular Weight    81,276 Da
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 NCBI Official Full Name    vascular cell adhesion molecule 1
 NCBI Official Synonym Full Names    vascular cell adhesion molecule 1
 NCBI Official Symbol    VCAM1 [Similar Products]
 NCBI Official Synonym Symbols   
CD106; INCAM-100
[Similar Products]
 NCBI Protein Information    vascular cell adhesion protein 1; CD106 antigen
 UniProt Protein Name    Vascular cell adhesion protein 1
 UniProt Synonym Protein Names   
INCAM-100
 Protein Family    Vascular cell adhesion protein
 UniProt Gene Name    VCAM1 [Similar Products]
 UniProt Synonym Gene Names    L1CAM; V-CAM 1; VCAM-1 [Similar Products]
 UniProt Entry Name    VCAM1_HUMAN
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 NCBI Summary for VCAM1    This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010]
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 UniProt Comments for VCAM1    VCAM1: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p32-p31

Cellular Component: Golgi apparatus; extracellular space; microvillus; cell surface; apical part of cell; endoplasmic reticulum; early endosome; plasma membrane; integral to membrane; podosome; sarcolemma; filopodium; external side of plasma membrane

Molecular Function: integrin binding; amine oxidase activity; cell adhesion molecule binding

Biological Process: response to nicotine; extracellular matrix organization and biogenesis; chronic inflammatory response; regulation of immune response; viral reproduction; heart development; cytokine and chemokine mediated signaling pathway; cell-matrix adhesion; response to lipopolysaccharide; heterophilic cell adhesion; leukocyte adhesion; response to ethanol; response to zinc ion; B cell differentiation; membrane to membrane docking; response to hypoxia; positive regulation of T cell proliferation; response to ionizing radiation; amine metabolic process; cell adhesion; leukocyte tethering or rolling; response to nutrient; acute inflammatory response; aging
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 Research Articles on VCAM1    1. SphK1 regulates tumor cell proliferation, apoptosis and invasion, which ultimately contributes to tumor progression and malignancy phenotype in colon cancer. FAK pathway, ICAM-1 and VCAM-1 may play critical roles in this SphK1mediated effect.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-VCAM1 antibodyPathways associated with anti-VCAM1 antibody
 Reference Product  PubMed Publications
 CD44 antibody  >13 publications with VCAM1 and CD44
 ITGA4 antibody  >7 publications with VCAM1 and ITGA4
 ITGB2 antibody  >5 publications with VCAM1 and ITGB2
 VEGFA antibody  >3 publications with VCAM1 and VEGFA
 ITGB1 antibody  >2 publications with VCAM1 and ITGB1
 ITGAD antibody  >1 publications with VCAM1 and ITGAD
 SRC antibody  >1 publications with VCAM1 and SRC
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cellular Roles Of Anthrax Toxin Pathway antibodies  Cellular Roles Of Anthrax Toxin Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
Diseases associated with anti-VCAM1 antibodyOrgans/Tissues associated with anti-VCAM1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >62 publications with VCAM1 and Inflammation
 Cardiovascular Diseases Antibodies  >46 publications with VCAM1 and Cardiovascular Diseases
 Necrosis Antibodies  >43 publications with VCAM1 and Necrosis
 Neoplasms Antibodies  >35 publications with VCAM1 and Neoplasms
 Atherosclerosis Antibodies  >31 publications with VCAM1 and Atherosclerosis
 Hypertension Antibodies  >11 publications with VCAM1 and Hypertension
 Heart Diseases Antibodies  >10 publications with VCAM1 and Heart Diseases
 Kidney Diseases Antibodies  >10 publications with VCAM1 and Kidney Diseases
 Myocardial Ischemia Antibodies  >8 publications with VCAM1 and Myocardial Ischemia
 Myocardial Infarction Antibodies  >7 publications with VCAM1 and Myocardial Infarction
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >166 publications with VCAM1 and Vascular
 Blood Antibodies  >95 publications with VCAM1 and Blood
 Kidney Antibodies  >19 publications with VCAM1 and Kidney
 Embryonic Tissue Antibodies  >19 publications with VCAM1 and Embryonic Tissue
 Brain Antibodies  >15 publications with VCAM1 and Brain
 Liver Antibodies  >13 publications with VCAM1 and Liver
 Heart Antibodies  >11 publications with VCAM1 and Heart
 Lung Antibodies  >9 publications with VCAM1 and Lung
 Placenta Antibodies  >7 publications with VCAM1 and Placenta
 Skin Antibodies  >6 publications with VCAM1 and Skin
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