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anti-VEGF121 antibody :: Mouse anti-Human Vascular Endothelial Growth Factor 121 (VEGF121) Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2090565
Unit / Price
0.01 mg  /  $110 +1 FREE 8GB USB
0.02 mg  /  $115 +1 FREE 8GB USB
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $195 +1 FREE 8GB USB
0.2 mg  /  $255 +1 FREE 8GB USB
1 mg  /  $590 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Vascular Endothelial Growth Factor 121 (VEGF121), Monoclonal Antibody

 Also Known As   

Monoclonal Antibody to Vascular Endothelial Growth Factor 121 (VEGF121)

 Product Gene Name   

anti-VEGF121 antibody

[Similar Products]
 Matching Pairs    Antibody: Vascular Endothelial Growth Factor 121 (VEGF121) Clone #C2 (MBS2090565)
Antigen: Vascular Endothelial Growth Factor 121 (MBS2029726)
 Matching Pairs    Unconjugated Antibody: Vascular Endothelial Growth Factor 121 (VEGF121) Clone #C2 (MBS2090565)
APC: Vascular Endothelial Growth Factor 121 (VEGF121) (MBS2059837)
 Matching Pairs    Unconjugated Antibody: Vascular Endothelial Growth Factor 121 (VEGF121) Clone #C2 (MBS2090565)
PE Conjugated Antibody: Vascular Endothelial Growth Factor 121 (VEGF121) (MBS2059839)
 Matching Pairs    Unconjugated Antibody: Vascular Endothelial Growth Factor 121 (VEGF121) Clone #C2 (MBS2090565)
APC: Vascular Endothelial Growth Factor 121 (VEGF121) (MBS2059841)
 Matching Pairs    Unconjugated Antibody: Vascular Endothelial Growth Factor 121 (VEGF121) Clone #C2 (MBS2090565)
Cy3 Conjugated Antibody: Vascular Endothelial Growth Factor 121 (VEGF121) (MBS2059843)
 Matching Pairs    Unconjugated Antibody: Vascular Endothelial Growth Factor 121 (VEGF121) Clone #C2 (MBS2090565)
FITC Conjugated Antibody: Vascular Endothelial Growth Factor 121 (VEGF121) (MBS2059845)
 Matching Pairs    Unconjugated Antibody: Vascular Endothelial Growth Factor 121 (VEGF121) Clone #C2 (MBS2090565)
HRP Conjugated Antibody: Vascular Endothelial Growth Factor 121 (VEGF121) (MBS2059847)
 Matching Pairs    Unconjugated Antibody: Vascular Endothelial Growth Factor 121 (VEGF121) Clone #C2 (MBS2090565)
Biotin Conjugated Secondary Antibody: IgG (MBS2086030)
 Matching Pairs    Unconjugated Antibody: Vascular Endothelial Growth Factor 121 (VEGF121) Clone #C2 (MBS2090565)
FITC Conjugated Secondary Antibody: IgG (MBS2086031)
 Matching Pairs    Unconjugated Antibody: Vascular Endothelial Growth Factor 121 (VEGF121) Clone #C2 (MBS2090565)
Biotin Conjugated Secondary Antibody: IgG (MBS2086033)
 Matching Pairs    Unconjugated Antibody: Vascular Endothelial Growth Factor 121 (VEGF121) Clone #C2 (MBS2090565)
FITC Conjugated Secondary Antibody: IgG (MBS2086034)
 Matching Pairs    Unconjugated Antibody: Vascular Endothelial Growth Factor 121 (VEGF121) Clone #C2 (MBS2090565)
HRP Conjugated Secondary Antibody: IgG (MBS2086035)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M32977 mRNA
 3D Structure    ModBase 3D Structure for P15692
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 Clonality    Monoclonal
 Isotype    IgG2b Kappa
 Clone Number    C2
 Host    Mouse
 Species Reactivity    Human
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 Specificity    The antibody is a mouse monoclonal antibody raised against VEGF121. It has been selected for its ability to recognize VEGF121 in immunohistochemical staining and western blotting.
 Purity/Purification    Protein A + Protein G affinity chromatography
 Form/Format    Liquid
 Concentration    1mg/mL (lot specific)
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 Immunogen    Recombinant Vascular Endothelial Growth Factor 121 (VEGF121)
 Buffer Formulation    0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2059841
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-VEGF121 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-VEGF121 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)

 Application Notes for anti-VEGF121 antibody    Western Blot: 0.5-5ug/mL
Immunocytochemistry in formalin fixed cells: 5-30ug/mL
Immunohistochemistry in formalin fixed frozen section: 5-30ug/mL
Immunohistochemistry in paraffin section: 5-30ug/mL
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 Western Blot (WB) of anti-VEGF121 antibody    (Figure. Western Blot; Sample: Recombinant VEGF121, Human.)
anti-VEGF121 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-VEGF121 antibody    (Figure. DAB staining on IHC-P; Samples: Human Liver Tissue.)
anti-VEGF121 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-VEGF121 antibody    (Figure. DAB staining on IHC-P; Samples: Human Liver Cancer Tissue.)
anti-VEGF121 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-VEGF121 antibody    (Figure. DAB staining on IHC-P; Samples: Human Thyroid Cancer Tissue.)
anti-VEGF121 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-VEGF121 antibody    (Figure. DAB staining on IHC-P; Samples: Human Lung Cancer Tissue.)
anti-VEGF121 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for VEGF121. It may not necessarily be applicable to this product.
 NCBI GI #    76781480
 NCBI GeneID    7422
 NCBI Accession #    NP_001020537.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001025366.2 [Other Products]
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 UniProt Primary Accession #    P15692 [Other Products]
 UniProt Secondary Accession #    O60720; O75875; Q074Z4; Q16889; B5BU86; H0Y2S8; H0Y407; H0Y414; H0Y462; H0Y8N2; H3BLW7 [Other Products]
 UniProt Related Accession #    P15692 [Other Products]
 Molecular Weight    34,406 Da
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 NCBI Official Full Name    vascular endothelial growth factor A isoform a
 NCBI Official Synonym Full Names    vascular endothelial growth factor A
 NCBI Official Symbol    VEGFA [Similar Products]
 NCBI Official Synonym Symbols   
VPF; VEGF; MVCD1
[Similar Products]
 NCBI Protein Information    vascular endothelial growth factor A
 UniProt Protein Name    Vascular endothelial growth factor A
 UniProt Synonym Protein Names   
Vascular permeability factor; VPF
 UniProt Gene Name    VEGFA [Similar Products]
 UniProt Synonym Gene Names    VEGF; VEGF-A; VPF [Similar Products]
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 NCBI Summary for VEGF121    This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]
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 UniProt Comments for VEGF121    Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development ().
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 Research Articles on VEGF121    1. AAV-CRISRP/Cas9-mediated depletion of VEGFR2 is a potential therapeutic strategy for pathologic angiogenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-VEGF121 antibodyDiseases associated with anti-VEGF121 antibody
 Products by Pathway  Pathway Diagram
 Angiogenesis Pathway antibodies  Angiogenesis Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Cellular Response To Hypoxia Pathway antibodies  Cellular Response To Hypoxia Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2318 publications with VEGF121 and Neoplasms
 Neovascularization, Pathologic Antibodies  >1534 publications with VEGF121 and Neovascularization, Pathologic
 Retinal Diseases Antibodies  >1048 publications with VEGF121 and Retinal Diseases
 Macular Degeneration Antibodies  >705 publications with VEGF121 and Macular Degeneration
 Choroidal Neovascularization Antibodies  >381 publications with VEGF121 and Choroidal Neovascularization
 Neoplasm Metastasis Antibodies  >379 publications with VEGF121 and Neoplasm Metastasis
 Inflammation Antibodies  >340 publications with VEGF121 and Inflammation
 Diabetic Retinopathy Antibodies  >337 publications with VEGF121 and Diabetic Retinopathy
 Macular Edema Antibodies  >245 publications with VEGF121 and Macular Edema
 Heart Diseases Antibodies  >225 publications with VEGF121 and Heart Diseases
Organs/Tissues associated with anti-VEGF121 antibody
 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >6105 publications with VEGF121 and Vascular
 Blood Antibodies  >2386 publications with VEGF121 and Blood
 Eye Antibodies  >1052 publications with VEGF121 and Eye
 Bone Antibodies  >422 publications with VEGF121 and Bone
 Lung Antibodies  >401 publications with VEGF121 and Lung
 Muscle Antibodies  >376 publications with VEGF121 and Muscle
 Embryonic Tissue Antibodies  >340 publications with VEGF121 and Embryonic Tissue
 Heart Antibodies  >299 publications with VEGF121 and Heart
 Kidney Antibodies  >256 publications with VEGF121 and Kidney
 Liver Antibodies  >251 publications with VEGF121 and Liver
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