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anti-VIM antibody :: Mouse Vimentin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS140125 anti-VIM antibody
Unit / Price
0.5 mg  /  $410 +1 FREE 8GB USB
1 mg  /  $550 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Vimentin, Monoclonal Antibody

 Also Known As   

Mouse Anti Human Vimentin FITC

 Product Synonym Names    Vimentin Antibody, FITC; Vimentin, Mouse Anti Human Antibody, FITC; Vimentin FITC
 Product Gene Name   

anti-VIM antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    116300
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    hVimentin
 Host    Mouse
 Species Reactivity    Vimentin antibody will recognize most mammalian Vimentin except mouse and rat.
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 Purity/Purification    Ion exchange column.
 Concentration    1mg/ml in PBS (after reconstitution). (lot specific)
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 Other Available Forms    This antibody is also available conjugated to Biotin and non conjugate form.
 Reconstitution    Reconstitute with H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
 Immunogen    Purified Human Vimentin.
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 Preparation and Storage    In lyophilized form, for long periods, store at 4 degree C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C.
Antibody is shipped lyophilized at ambient temperature.
 Other Notes    Small volumes of anti-VIM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-VIM antibody

   Introduction: Vimentin expression in human malignant glioma cells depends on cellular density, algorithms of drug delivery and chemo/radio treatment. Vimentin and detyrosinated microtubules provide structural support for the extensive microtentacles observed in detached tumor cells and a mechanism to promote successful metastatic spread. Primary colorectal carcinomas display aberrant expression of vimentin, and have activated Notch and TGFbeta signaling pathways. Vimentin is a strong arterial substrate for transglutaminases. Transglutaminase-mediated vimentin dimerization results in a novel unifying pathway by which vasodilatory and remodeling responses may be regulated. Ablation of vimentin expression inhibits migration and invasion of colon and breast cancer cell lines.
 Product Categories/Family for anti-VIM antibody    MONOCLONAL/POLYCLONAL ANTIBODIES, MISCELLANEOUS ANTIBODIES; Monoclonal Antibodies
 Applications Tested/Suitable for anti-VIM antibody   

Immunohistochemistry (IHC)

 Application Notes for anti-VIM antibody    For intra-cellular staining, use 5-10 ul/1,000,000 cells. Wash twice with PBS/Azide before adding the appropriate amount of secondary fluorescent reagent.
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NCBI/Uniprot data below describe general gene information for VIM. It may not necessarily be applicable to this product.
 NCBI GI #    62414289
 NCBI GeneID    7431
 NCBI Accession #    NP_003371.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003380.3 [Other Products]
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 UniProt Secondary Accession #    Q15867; Q15868; Q15869; Q548L2; Q6LER9; Q8N850; Q96ML2; Q9NTM3; B0YJC2; D3DRU4 [Other Products]
 UniProt Related Accession #    P08670 [Other Products]
 Molecular Weight    53,652 Da [Similar Products]
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 NCBI Official Full Name    vimentin
 NCBI Official Synonym Full Names    vimentin
 NCBI Official Symbol    VIM [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    vimentin; epididymis luminal protein 113
 UniProt Protein Name    Vimentin
 Protein Family    Vimentin
 UniProt Gene Name    VIM [Similar Products]
 UniProt Entry Name    VIME_HUMAN
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 NCBI Summary for VIM    This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009]
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 UniProt Comments for VIM    Vimentin: an intermediate filament protein. Intermediate filament proteins are expressed in a tissue-specific manner. Desmin is the subunit specific for muscle and vimentin the subunit specific for mesenchymal tissue.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10p13

Cellular Component: intermediate filament cytoskeleton; neuron projection; cytoskeleton; focal adhesion; cytoplasm; leading edge; plasma membrane; intermediate filament; peroxisome; cytosol

Molecular Function: protein C-terminus binding; identical protein binding; protein binding; structural constituent of cytoskeleton; double-stranded RNA binding; glycoprotein binding; structural constituent of eye lens

Biological Process: Bergmann glial cell differentiation; viral reproduction; apoptosis; intermediate filament organization; cell motility; astrocyte development; muscle filament sliding; cell structure disassembly during apoptosis

Disease: Cataract 30
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 Research Articles on VIM    1. Vimentin, an antigenic feature of inflammation, is a dominant autoantigen targeted in situ in lupus nephritis (LN) tubulointerstitial inflammation (TII). This adaptive autoimmune response likely feeds forward to worsen TII and renal damage.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-VIM antibodyDiseases associated with anti-VIM antibody
 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway antibodies  Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >420 publications with VIM and Nervous System Diseases
 Neurodegenerative Diseases Antibodies  >178 publications with VIM and Neurodegenerative Diseases
 Inflammation Antibodies  >56 publications with VIM and Inflammation
 Kidney Diseases Antibodies  >40 publications with VIM and Kidney Diseases
 Pain Antibodies  >37 publications with VIM and Pain
 Disease Models, Animal Antibodies  >36 publications with VIM and Disease Models, Animal
 Hemorrhage Antibodies  >34 publications with VIM and Hemorrhage
 Neoplasm Metastasis Antibodies  >33 publications with VIM and Neoplasm Metastasis
 Liver Diseases Antibodies  >33 publications with VIM and Liver Diseases
 Breast Neoplasms Antibodies  >31 publications with VIM and Breast Neoplasms
Organs/Tissues associated with anti-VIM antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >505 publications with VIM and Brain
 Blood Antibodies  >216 publications with VIM and Blood
 Muscle Antibodies  >118 publications with VIM and Muscle
 Nerve Antibodies  >83 publications with VIM and Nerve
 Bone Antibodies  >77 publications with VIM and Bone
 Kidney Antibodies  >60 publications with VIM and Kidney
 Liver Antibodies  >57 publications with VIM and Liver
 Bone Marrow Antibodies  >52 publications with VIM and Bone Marrow
 Eye Antibodies  >48 publications with VIM and Eye
 Lung Antibodies  >40 publications with VIM and Lung
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