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anti-VIM antibody :: Mouse anti-Human, Rat Vimentin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS246052
Unit / Price
0.05 mL  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Vimentin, Monoclonal Antibody

 Also Known As   

Mouse Monoclonal [clone 35E2] (IgG1,k) to Human Vimentin

 Product Synonym Names    Anti-Vimentin Antibody (clone 35E2) IHC-plus; Vimentin; Human Vimentin
 Product Gene Name   

anti-VIM antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 193060
 3D Structure    ModBase 3D Structure for P08670
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 Clonality    Monoclonal
 Isotype    IgG1,k
 Clone Number    35E2
 Host    Mouse
 Species Reactivity    Human, Rat
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 Purity/Purification    Ammonium sulfate precipitation
 Form/Format    HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol
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 Target Species    Human
 Immunogen Description    Recombinant human protein purified from E Coli (His-Vimentin).
 Immunogen Type    Recombinant protein
 Immunogen    Vimentin antibody was raised against recombinant human protein purified from E Coli (His-Vimentin).
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-VIM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-VIM antibody

   Vimentin (VIM) is a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. Vimentin is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification.
 Applications Tested/Suitable for anti-VIM antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-VIM antibody    IHC-P (1:400), WB (1:2000)
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 Immunohistochemistry (IHC) of anti-VIM antibody    Anti-Vimentin antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:400.
anti-VIM antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-VIM antibody     
anti-VIM antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for VIM. It may not necessarily be applicable to this product.
 NCBI GI #    62414289
 NCBI GeneID    7431
 NCBI Accession #    NP_003371.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_003380.3 [Other Products]
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 UniProt Primary Accession #    P08670 [Other Products]
 UniProt Secondary Accession #    Q15867; Q15868; Q15869; Q548L2; Q6LER9; Q8N850; Q96ML2; Q9NTM3; B0YJC2; D3DRU4 [Other Products]
 UniProt Related Accession #    P08670 [Other Products]
 Molecular Weight    53,652 Da
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 NCBI Official Full Name    vimentin
 NCBI Official Synonym Full Names    vimentin
 NCBI Official Symbol    VIM [Similar Products]
 NCBI Official Synonym Symbols   
HEL113; CTRCT30
[Similar Products]
 NCBI Protein Information    vimentin; epididymis luminal protein 113
 UniProt Protein Name    Vimentin
 Protein Family    Vimentin
 UniProt Gene Name    VIM [Similar Products]
 UniProt Entry Name    VIME_HUMAN
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 NCBI Summary for VIM    This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009]
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 UniProt Comments for VIM    Vimentin: an intermediate filament protein. Intermediate filament proteins are expressed in a tissue-specific manner. Desmin is the subunit specific for muscle and vimentin the subunit specific for mesenchymal tissue.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 10p13

Cellular Component: intermediate filament cytoskeleton; neuron projection; focal adhesion; cytoskeleton; cytoplasm; leading edge; plasma membrane; intermediate filament; peroxisome; cytosol

Molecular Function: protein C-terminus binding; identical protein binding; protein binding; structural constituent of cytoskeleton; double-stranded RNA binding; glycoprotein binding; structural constituent of eye lens

Biological Process: Bergmann glial cell differentiation; viral reproduction; apoptosis; intermediate filament organization; cell motility; astrocyte development; muscle filament sliding; cell structure disassembly during apoptosis

Disease: Cataract 30
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 Research Articles on VIM    1. In the doxorubicin resistant MCF-7 cells, high levels of vimentin expression were observed.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-VIM antibodyDiseases associated with anti-VIM antibody
 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway antibodies  Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >418 publications with VIM and Nervous System Diseases
 Neurodegenerative Diseases Antibodies  >177 publications with VIM and Neurodegenerative Diseases
 Inflammation Antibodies  >53 publications with VIM and Inflammation
 Kidney Diseases Antibodies  >41 publications with VIM and Kidney Diseases
 Pain Antibodies  >37 publications with VIM and Pain
 Disease Models, Animal Antibodies  >36 publications with VIM and Disease Models, Animal
 Hemorrhage Antibodies  >34 publications with VIM and Hemorrhage
 Liver Diseases Antibodies  >34 publications with VIM and Liver Diseases
 Neoplasm Metastasis Antibodies  >32 publications with VIM and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >29 publications with VIM and Breast Neoplasms
Organs/Tissues associated with anti-VIM antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >504 publications with VIM and Brain
 Blood Antibodies  >217 publications with VIM and Blood
 Muscle Antibodies  >116 publications with VIM and Muscle
 Nerve Antibodies  >83 publications with VIM and Nerve
 Bone Antibodies  >77 publications with VIM and Bone
 Kidney Antibodies  >60 publications with VIM and Kidney
 Liver Antibodies  >58 publications with VIM and Liver
 Bone Marrow Antibodies  >52 publications with VIM and Bone Marrow
 Eye Antibodies  >48 publications with VIM and Eye
 Ganglia Antibodies  >41 publications with VIM and Ganglia
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