NM_006103.3
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
11,043 Da
NCBI Official Full Name
WAP four-disulfide core domain protein 2
NCBI Official Synonym Full Names
WAP four-disulfide core domain 2
NCBI Protein Information
WAP four-disulfide core domain protein 2
UniProt Protein Name
WAP four-disulfide core domain protein 2
UniProt Synonym Protein Names
Epididymal secretory protein E4; Major epididymis-specific protein E4; Putative protease inhibitor WAP5
UniProt Synonym Gene Names
UniProt Entry Name
WFDC2_HUMAN
NCBI Summary for WAP5/WFDC2/HE4
This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]
UniProt Comments for WAP5/WFDC2/HE4
WFDC2: a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 20q13.12
Cellular Component: extracellular space
Molecular Function: aspartic-type endopeptidase inhibitor activity; endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity
Biological Process: proteolysis; spermatogenesis
Research Articles on WAP5/WFDC2/HE4
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Products associated with anti-WAP5/WFDC2/HE4 antibody
Diseases associated with anti-WAP5/WFDC2/HE4 antibody
Organs/Tissues associated with anti-WAP5/WFDC2/HE4 antibody
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