NP_003922.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,652 Da
NCBI Official Full Name
wiskott-Aldrich syndrome protein family member 1
NCBI Official Synonym Full Names
WAS protein family, member 1
NCBI Protein Information
wiskott-Aldrich syndrome protein family member 1; protein WAVE-1; WASP family protein member 1; homology of dictyostelium scar 1; verprolin homology domain-containing protein 1
UniProt Protein Name
Wiskott-Aldrich syndrome protein family member 1
UniProt Synonym Protein Names
Protein WAVE-1; Verprolin homology domain-containing protein 1
UniProt Synonym Gene Names
UniProt Entry Name
WASF1_HUMAN
NCBI Summary for WASF1
The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for WASF1
WAVE1: Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Belongs to the SCAR/WAVE family.
Protein type: Motility/polarity/chemotaxis; Cytoskeletal
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: cytoskeleton; synapse; cell junction; actin cytoskeleton
Molecular Function: protein binding; protein complex binding; Rac GTPase binding; actin binding
Biological Process: actin filament polymerization; Rac protein signal transduction; protein complex assembly; cell motility
Research Articles on WASF1
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Products associated with anti-WASF1 antibody
Pathways associated with anti-WASF1 antibody
Diseases associated with anti-WASF1 antibody
Organs/Tissues associated with anti-WASF1 antibody
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