NP_077007.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,651 Da
NCBI Official Full Name
methylosome protein 50
NCBI Official Synonym Full Names
WD repeat domain 77
NCBI Official Synonym Symbols
p44; MEP50; MEP-50; HKMT1069; Nbla10071; p44/Mep50 [Similar Products]
NCBI Protein Information
methylosome protein 50; androgen receptor cofactor p44; WD repeat-containing protein 77
UniProt Protein Name
Methylosome protein 50
UniProt Synonym Protein Names
Androgen receptor cofactor p44; WD repeat-containing protein 77; p44/Mep50
UniProt Synonym Gene Names
UniProt Entry Name
MEP50_HUMAN
NCBI Summary for WDR77
WDR77 is a component of the 20S PRMT5 (MIM 604045)-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins (see MIM 601061). This modification targets Sm proteins to the survival of motor neurons (SMN) complex (see MIM 600354) for assembly into small nuclear ribonucleoprotein core particles (Friesen et al., 2002 [PubMed 11756452]).[supplied by OMIM, Mar 2008]
UniProt Comments for WDR77
WDR77: a WD40 repeat protein. Component of the methylosome, a 20S complex containing at least ICLN, SKB1 and WDR77. Interacts with SKB1 and with SM proteins. The methylosome may regulate an early step in the assembly of U snRNPs, possibly the transfer of Sm proteins to the SMN-complex. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly.
Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator; Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1p13.2
Cellular Component: nucleoplasm; Golgi apparatus; cytoplasm; nucleus; cytosol
Molecular Function: protein binding; ligand-dependent nuclear receptor transcription coactivator activity
Biological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; spliceosomal snRNP biogenesis; positive regulation of cell proliferation; gene expression
Research Articles on WDR77
Precautions
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Products associated with anti-WDR77 antibody
Pathways associated with anti-WDR77 antibody
Diseases associated with anti-WDR77 antibody
Organs/Tissues associated with anti-WDR77 antibody
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