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anti-WISP2 antibody :: Mouse anti-Human WISP2 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS246020
Unit / Price
0.05 mg  /  $595 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

WISP2, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse Monoclonal [clone 1E11] (IgG2a,k) to Human WISP2

 Product Synonym Names    Anti-WISP2 Antibody (clone 1E11) IHC-plus; WISP2; CCN5; CCN family member 5; CTGFL; CT58; CTGF-L; WISP-2; Human WISP2
 Product Gene Name   

anti-WISP2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603399
 3D Structure    ModBase 3D Structure for O76076
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 Clonality    Monoclonal
 Isotype    IgG2a,k
 Clone Number    1E11
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Human WISP2
 Purity/Purification    Protein A purified
 Form/Format    PBS, pH 7.4. Sourced in Ascites.
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    WISP2 antibody was raised against recombinant protein
 Antigen Type    Recombinant protein
 Presentation    PBS, pH 7.4. Sourced in Ascites
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-WISP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-WISP2 antibody

   WISP2 is a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
 Applications Tested/Suitable for anti-WISP2 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-WISP2 antibody    ELISA, IHC-P (5 ug/ml), WB (1:500 - 1:1000), ELISA (Optimal dilution to be determined by the researcher)
Usage: Western Blot: Transfected lysate, Recombinant protein.
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 Immunohistochemistry (IHC) of anti-WISP2 antibody    Anti-WISP2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-WISP2 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-WISP2 antibody    Western blot of WISP2 expression in transfected 293T cell line by WISP2 monoclonal antibody, clone 1E11.
anti-WISP2 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for WISP2. It may not necessarily be applicable to this product.
 NCBI GI #    4507923
 NCBI GeneID    8839
 NCBI Accession #    NP_003872.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003881.2 [Other Products]
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 UniProt Primary Accession #    O76076 [Other Products]
 UniProt Secondary Accession #    Q6PEG3; B2R9N4; E1P612 [Other Products]
 UniProt Related Accession #    O76076 [Other Products]
 Molecular Weight    22,577 Da
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 NCBI Official Full Name    WNT1-inducible-signaling pathway protein 2
 NCBI Official Synonym Full Names    WNT1 inducible signaling pathway protein 2
 NCBI Official Symbol    WISP2 [Similar Products]
 NCBI Official Synonym Symbols   
CCN5; CT58; CTGF-L
[Similar Products]
 NCBI Protein Information    WNT1-inducible-signaling pathway protein 2; WISP-2; CCN family member 5; wnt-1 signaling pathway protein 2; connective tissue growth factor-like protein; connective tissue growth factor-related protein 58
 UniProt Protein Name    WNT1-inducible-signaling pathway protein 2
 UniProt Synonym Protein Names   
CCN family member 5; Connective tissue growth factor-like protein; CTGF-L; Connective tissue growth factor-related protein 58
 Protein Family    WNT1-inducible-signaling pathway protein
 UniProt Gene Name    WISP2 [Similar Products]
 UniProt Synonym Gene Names    CCN5; CT58; CTGFL; WISP-2; CTGF-L [Similar Products]
 UniProt Entry Name    WISP2_HUMAN
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 NCBI Summary for WISP2    This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008]
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 UniProt Comments for WISP2    WISP2: May play an important role in modulating bone turnover. Promotes the adhesion of osteoblast cells and inhibits the binding of fibrinogen to integrin receptors. In addition, inhibits osteocalcin production. Belongs to the CCN family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: extracellular space; proteinaceous extracellular matrix; plasma membrane

Molecular Function: integrin binding; heparin binding; insulin-like growth factor binding

Biological Process: cell-cell signaling; regulation of cell growth; cell adhesion; signal transduction
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 Research Articles on WISP2    1. The obtained results indicate that the changes in gene expression in bone marrow progenitor cells can be involved into space flight-induced osteopenia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-WISP2 antibodyDiseases associated with anti-WISP2 antibody
 Reference Product  PubMed Publications
 IGF1 antibody  >2 publications with WISP2 and IGF1
 TGFB1 antibody  >2 publications with WISP2 and TGFB1
 HDAC1 antibody  >1 publications with WISP2 and HDAC1
 IGF2 antibody  >1 publications with WISP2 and IGF2
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >28 publications with WISP2 and Breast Neoplasms
 Inflammation Antibodies  >7 publications with WISP2 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >6 publications with WISP2 and Cell Transformation, Neoplastic
 Hyperplasia Antibodies  >6 publications with WISP2 and Hyperplasia
 Liver Diseases Antibodies  >5 publications with WISP2 and Liver Diseases
 Cardiovascular Diseases Antibodies  >4 publications with WISP2 and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with WISP2 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >3 publications with WISP2 and Liver Neoplasms
 Neoplasms, Experimental Antibodies  >2 publications with WISP2 and Neoplasms, Experimental
 Heart Diseases Antibodies  >2 publications with WISP2 and Heart Diseases
Organs/Tissues associated with anti-WISP2 antibody
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >25 publications with WISP2 and Connective Tissue
 Bone Antibodies  >16 publications with WISP2 and Bone
 Muscle Antibodies  >14 publications with WISP2 and Muscle
 Blood Antibodies  >6 publications with WISP2 and Blood
 Liver Antibodies  >5 publications with WISP2 and Liver
 Lung Antibodies  >5 publications with WISP2 and Lung
 Uterus Antibodies  >3 publications with WISP2 and Uterus
 Pancreas Antibodies  >3 publications with WISP2 and Pancreas
 Lymph Node Antibodies  >2 publications with WISP2 and Lymph Node
 Ovary Antibodies  >2 publications with WISP2 and Ovary
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