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anti-WNT4 antibody :: Mouse anti-Human, Mouse WNT4 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9217056
Western Blot (WB)
Unit / Price
0.05 mL  /  $150 +1 FREE 8GB USB
0.2 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

WNT4, Monoclonal Antibody

★Popular Item★
 Also Known As   

WNT4 Antibody

 Product Synonym Names    Protein Wnt-4; WNT4
 Product Gene Name   

anti-WNT4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    158330
 3D Structure    ModBase 3D Structure for P56705
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 Clonality    Monoclonal
 Isotype    IgG1,k
 Clone Number    1698CT540.169.185
 Host    Mouse
 Species Reactivity    Human, Mouse
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 Specificity    This WNT4 antibody is generated from a mouse immunized with a recombinant protein between 30-351 amino acids from human WNT4.
 Form/Format    Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
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 Subtitle    Purified Mouse Monoclonal Antibody (Mab)
 Cellular Location    Secreted, extracellular space, extracellular matrix.
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 2 weeks. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-WNT4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-WNT4 antibody

   Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity). Overexpression may be associated with abnormal proliferation in human breast tissue.
 Product Categories/Family for anti-WNT4 antibody    Crown Antibodies; New Antibodies; Primary Antibodies; Cancer; Developmental Biology; Signal Transduction; Stem Cells
 Applications Tested/Suitable for anti-WNT4 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-WNT4 antibody    WB:~~1:4000
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 Western Blot (WB) of anti-WNT4 antibody    All lanes : Anti-WNT4 Antibody at 1:4000 dilution
Lane 1: Hela whole cell lysate
Lane 2: MCF-7 whole cell lysate
Lane 3: mouse lung lysate
Lane 4: SK-BR-3 whole cell lysate
Lane 5: MDA-MB-231 whole cell lysate
Lysates/proteins at 20 ug per lane.
Secondary
Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution.
Predicted band size : 39 kDa
Blocking/Dilution buffer: 5% NFDM/TBST.
anti-WNT4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for WNT4. It may not necessarily be applicable to this product.
 NCBI GI #    17402922
 NCBI GeneID    54361
 NCBI Accession #    NP_110388.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_030761.4 [Other Products]
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 UniProt Primary Accession #    P56705 [Other Products]
 UniProt Secondary Accession #    Q5TZQ0; Q96T81; Q9BXF5; Q9H1J8; Q9UJM2; B4DJF9 [Other Products]
 UniProt Related Accession #    P56705 [Other Products]
 Molecular Weight    39052
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 NCBI Official Full Name    protein Wnt-4
 NCBI Official Synonym Full Names    Wnt family member 4
 NCBI Official Symbol    WNT4 [Similar Products]
 NCBI Official Synonym Symbols   
WNT-4; SERKAL
[Similar Products]
 NCBI Protein Information    protein Wnt-4
 UniProt Protein Name    Protein Wnt-4
 UniProt Gene Name    WNT4 [Similar Products]
 UniProt Entry Name    WNT4_HUMAN
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 NCBI Summary for WNT4    The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008]
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 UniProt Comments for WNT4    WNT4: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Overexpression may be associated with abnormal proliferation in human breast tissue. Defects in WNT4 are a cause of Rokitansky-Kuster-Hauser syndrome (RKH syndrome); also called Mayer- Rokitansky-Kuster-Hauser syndrome (MRKH syndrome or MRKH anomaly). RKH syndrome is characterized by utero-vaginal atresia in otherwise phenotypically normal female with a normal 46,XX karyotype. Anomalies of the genital tract range from upper vaginal atresia to total Muellerian agenesis with urinary tract abnormalities. It has an incidence of approximately 1 in 5'000 newborn girls. Defects in WNT4 are the cause of female sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL); also known as SERKAL syndrome. Defects in WNT4 are the cause of Muellerian aplasia (MULLAPL). Belongs to the Wnt family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1p36.23-p35.1

Cellular Component: cell surface; cytoplasm; endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi lumen; plasma membrane; proteinaceous extracellular matrix

Molecular Function: frizzled binding; receptor agonist activity; transcription corepressor activity

Biological Process: adrenal gland development; androgen biosynthetic process; cell fate commitment; cellular response to starvation; embryonic epithelial tube formation; epithelial to mesenchymal transition; female gonad development; female sex determination; immature T cell proliferation in the thymus; kidney development; liver development; male gonad development; negative regulation of cell differentiation; negative regulation of cell migration; negative regulation of fibroblast growth factor receptor signaling pathway; negative regulation of transcription, DNA-dependent; neuron differentiation; oocyte development; positive regulation of aldosterone biosynthetic process; positive regulation of bone mineralization; positive regulation of collagen biosynthetic process; positive regulation of focal adhesion formation; positive regulation of GTPase activity; positive regulation of meiosis; positive regulation of osteoblast differentiation; positive regulation of stress fiber formation; positive regulation of transcription, DNA-dependent; regulation of cell-cell adhesion; smooth muscle cell differentiation; somatotropin secreting cell differentiation; thyroid stimulating hormone secreting cell differentiation; ureteric bud branching; Wnt receptor signaling pathway; Wnt receptor signaling pathway through beta-catenin

Disease: 46,xx Sex Reversal With Dysgenesis Of Kidneys, Adrenals, And Lungs; Mullerian Aplasia And Hyperandrogenism
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Product References and Citations for anti-WNT4 antibody

   Testa T.T.,et al.Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases. Jordan B.K.,et al.Am. J. Hum. Genet. 68:1102-1109 (2001). Clark H.F.,et al.Genome Res. 13:2265-2270 (2003). Ota T.,et al.Nat. Genet. 36:40-45 (2004). Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
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 Research Articles on WNT4    1. Polymorphisms on WNT4 gene might be involved in the pathogenesis of endometriosis in the infertile women.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-WNT4 antibodyPathways associated with anti-WNT4 antibody
 Reference Product  PubMed Publications
 PAX2 antibody  >23 publications with WNT4 and PAX2
 SFRP1 antibody  >12 publications with WNT4 and SFRP1
 SFRP2 antibody  >12 publications with WNT4 and SFRP2
 FZD6 antibody  >7 publications with WNT4 and FZD6
 SFRP4 antibody  >6 publications with WNT4 and SFRP4
 FZD4 antibody  >6 publications with WNT4 and FZD4
 FZD10 antibody  >5 publications with WNT4 and FZD10
 FZD9 antibody  >3 publications with WNT4 and FZD9
 FZD8 antibody  >1 publications with WNT4 and FZD8
 Products by Pathway  Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
Diseases associated with anti-WNT4 antibodyOrgans/Tissues associated with anti-WNT4 antibody
 Disease Name  Pubmed Publications
 Female Urogenital Diseases Antibodies  >70 publications with WNT4 and Female Urogenital Diseases
 Urogenital Abnormalities Antibodies  >36 publications with WNT4 and Urogenital Abnormalities
 Disorders of Sex Development Antibodies  >33 publications with WNT4 and Disorders of Sex Development
 Disease Models, Animal Antibodies  >17 publications with WNT4 and Disease Models, Animal
 Kidney Diseases Antibodies  >16 publications with WNT4 and Kidney Diseases
 Rokitansky Kuster Hauser syndrome Antibodies  >11 publications with WNT4 and Rokitansky Kuster Hauser syndrome
 Fibrosis Antibodies  >11 publications with WNT4 and Fibrosis
 Infertility, Female Antibodies  >8 publications with WNT4 and Infertility, Female
 Breast Neoplasms Antibodies  >8 publications with WNT4 and Breast Neoplasms
 Liver Diseases Antibodies  >7 publications with WNT4 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >94 publications with WNT4 and Kidney
 Embryonic Tissue Antibodies  >75 publications with WNT4 and Embryonic Tissue
 Ovary Antibodies  >74 publications with WNT4 and Ovary
 Uterus Antibodies  >39 publications with WNT4 and Uterus
 Brain Antibodies  >27 publications with WNT4 and Brain
 Mammary Gland Antibodies  >23 publications with WNT4 and Mammary Gland
 Eye Antibodies  >17 publications with WNT4 and Eye
 Heart Antibodies  >8 publications with WNT4 and Heart
 Lung Antibodies  >7 publications with WNT4 and Lung
 Placenta Antibodies  >5 publications with WNT4 and Placenta
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