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anti-RPL10 antibody :: Mouse anti-Human Wilm's Tumor Protein Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS603217 anti-RPL10 antibody
Unit / Price
0.2 mg  /  $620 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Wilm's Tumor Protein (RPL10), Monoclonal Antibody

 Also Known As   

Wilm's Tumor Protein (Wt1)

 Product Synonym Names    Anti -Wilm's Tumor Protein (Wt1)
 Product Gene Name   

anti-RPL10 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: X; NC_000023.10 (153626571..153630680). Location: Xq28
 OMIM    312173
 3D Structure    ModBase 3D Structure for P27635
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    4H383
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes human WT1, Mr ~55-60kD. A nonspecific protein was also detected, Mr ~68kD.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 0.105M sodium chloride, 0.05% sodium azide, 30% glycerol.
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 Immunogen    6 His-tagged fusion protein corresponding to residues 1-181 of human WT1 (Wilms' tumor).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-RPL10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-RPL10 antibody

   Wilm's Tumor (WT), a sporadic and familial childhood kidney tumor, is genetically heterogeneous. Wilms' tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilms tumor and mesothelioma.
 Product Categories/Family for anti-RPL10 antibody    Antibodies; Abs to Cancer Markers
 Applications Tested/Suitable for anti-RPL10 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

 Application Notes for anti-RPL10 antibody    Suitable for use in Western Blot, Immunocytochemistry and Immunohistochemistry.
Dilution: Western Blot: 0.5-1ug/ml detects WT1 in RIPA lysates from Jurkat and Raji cells. Raji cell lysate was resolved by electrophoresis, transferred to nitrocellulose and probed with W1125-11A. Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP* and a chemiluminescence detection system.
Immunocytochemistry: Reported to detect WT1 in mesothelioma cells.
Immunohistochemistry: Reported to detect WT1 in malignant mesothelioma sections.
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NCBI/Uniprot data below describe general gene information for RPL10. It may not necessarily be applicable to this product.
 NCBI GI #    190814
 NCBI GeneID    6134
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 UniProt Primary Accession #    P27635 [Other Products]
 UniProt Secondary Accession #    Q16470; Q2HXT7; Q53FH7; Q6FGN8; Q8TDA5; A3KQT0; D3DWW6 [Other Products]
 UniProt Related Accession #    P27635; Q5HY50; Q9GZW2 [Other Products]
 Molecular Weight    24,604 Da [Similar Products]
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 NCBI Official Full Name    Wilm's tumor-related protein
 NCBI Official Synonym Full Names    ribosomal protein L10
 NCBI Official Symbol    RPL10 [Similar Products]
 NCBI Official Synonym Symbols   
QM; L10; NOV; AUTSX5; DXS648; DXS648E; FLJ23544; FLJ27072; DKFZp686J1851
[Similar Products]
 NCBI Protein Information    60S ribosomal protein L10; OTTHUMP00000031945; OTTHUMP00000063212; OTTHUMP00000063213; OTTHUMP00000183506; OTTHUMP00000196447; tumor suppressor QM; laminin receptor homolog; Wilms tumor-related protein
 UniProt Protein Name    60S ribosomal protein L10
 UniProt Synonym Protein Names   
Laminin receptor homolog; Protein QM; Tumor suppressor QM
 Protein Family    60S ribosomal protein
 UniProt Gene Name    RPL10 [Similar Products]
 UniProt Synonym Gene Names    DXS648E; QM [Similar Products]
 UniProt Entry Name    RL10_HUMAN
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 NCBI Summary for RPL10    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L10E family of ribosomal proteins. It is located in the cytoplasm. In vitro studies have shown that the chicken protein can bind to c-Jun and can repress c-Jun-mediated transcriptional activation, but these activities have not been demonstrated in vivo. This gene was initially identified as a candidate for a Wilms tumor suppressor gene, but later studies determined that this gene is not involved in the suppression of Wilms tumor. This gene has been referred to as 'laminin receptor homolog' because a chimeric transcript consisting of sequence from this gene and sequence from the laminin receptor gene was isolated; however, it is not believed that this gene encodes a laminin receptor. Transcript variants utilizing alternative polyA signals exist. The variant with the longest 3' UTR overlaps the deoxyribonuclease I-like 1 gene on the opposite strand. This gene is co-transcribed with the small nucleolar RNA gene U70, which is located in its fifth intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq]
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 UniProt Comments for RPL10    RPL10: Defects in RPL10 are a cause of susceptibility to autism X-linked type 5 (AUTSX5). A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation. RPL10 is involved in autism only in rare cases. Two hypomorphic variants affecting the translation process have been found in families with autism spectrum disorders, suggesting that aberrant translation may play a role in disease mechanisms. Belongs to the ribosomal protein L10e family.

Protein type: Ribosomal; Translation

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: membrane; endoplasmic reticulum; cytosol

Molecular Function: protein binding; structural constituent of ribosome

Biological Process: SRP-dependent cotranslational protein targeting to membrane; cellular protein metabolic process; translational elongation; viral reproduction; translation; mRNA catabolic process, nonsense-mediated decay; translational initiation; gene expression; viral transcription; translational termination; viral infectious cycle

Disease: Autism, Susceptibility To, X-linked 5
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 Research Articles on RPL10    1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-RPL10 antibodyDiseases associated with anti-RPL10 antibody
 Products by Pathway  Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 Cytoplasmic Ribosomal Proteins Pathway antibodies  Cytoplasmic Ribosomal Proteins Pathway Diagram
 Diabetes Pathways antibodies  Diabetes Pathways Diagram
 Eukaryotic Translation Elongation Pathway antibodies  Eukaryotic Translation Elongation Pathway Diagram
 Eukaryotic Translation Initiation Pathway antibodies  Eukaryotic Translation Initiation Pathway Diagram
 Eukaryotic Translation Termination Pathway antibodies  Eukaryotic Translation Termination Pathway Diagram
 Formation Of A Pool Of Free 40S Subunits Pathway antibodies  Formation Of A Pool Of Free 40S Subunits Pathway Diagram
 GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway antibodies  GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Influenza Infection Pathway antibodies  Influenza Infection Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with RPL10 and Neoplasms
 Carcinoma Antibodies  >2 publications with RPL10 and Carcinoma
 Neurologic Manifestations Antibodies  >2 publications with RPL10 and Neurologic Manifestations
 Autistic Disorder Antibodies  >2 publications with RPL10 and Autistic Disorder
 Male Urogenital Diseases Antibodies  >1 publications with RPL10 and Male Urogenital Diseases
 Pancreatic Neoplasms Antibodies  >1 publications with RPL10 and Pancreatic Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with RPL10 and Carcinoma, Hepatocellular
 Cell Transformation, Neoplastic Antibodies  >1 publications with RPL10 and Cell Transformation, Neoplastic
 Adenoma Antibodies  >1 publications with RPL10 and Adenoma
 Liver Neoplasms Antibodies  >1 publications with RPL10 and Liver Neoplasms
Organs/Tissues associated with anti-RPL10 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3 publications with RPL10 and Brain
 Liver Antibodies  >2 publications with RPL10 and Liver
 Heart Antibodies  >2 publications with RPL10 and Heart
 Kidney Antibodies  >2 publications with RPL10 and Kidney
 Vascular Antibodies  >1 publications with RPL10 and Vascular
 Stomach Antibodies  >1 publications with RPL10 and Stomach
 Intestine Antibodies  >1 publications with RPL10 and Intestine
 Prostate Antibodies  >1 publications with RPL10 and Prostate
 Spleen Antibodies  >1 publications with RPL10 and Spleen
 Muscle Antibodies  >1 publications with RPL10 and Muscle
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