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anti-WNT4 antibody :: Rat anti-Human, Mouse Wnt4 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS606929 anti-WNT4 antibody
Unit / Price
0.1 mg  /  $605 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Wnt4, Monoclonal Antibody

 Also Known As   

Wnt4 (Wingless-type MMTV (Mouse Mammary Tumor Virus) Integration Site Family Member)

 Product Synonym Names    Anti -Wnt4 (Wingless-type MMTV (Mouse Mammary Tumor Virus) Integration Site Family Member)
 Product Gene Name   

anti-WNT4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (22443798..22469519, complement). Location: 1p36.23-p35.1
 OMIM    158330
 3D Structure    ModBase 3D Structure for P56705
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    9H192
 Host    Rat
 Species Reactivity    Human, Mouse
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 Specificity    Recognizes mouse Wnt-4. Species crossreactivity: human. Does not cross-react with recombinant mouse Wnt-1, 2b, 5a, 5b, 8a, 8b, 9b, 10a, 10b, 11, 16, or with recombinant human Wnt-2, 3a, 7a, or 7b.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.
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 Immunogen    Recombinant corresponding to aa37-76 from mouse Wnt-4, expressed in E. coli (NP_033549).
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-WNT4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-WNT4 antibody

   Wnt-4 is a secreted glycoprotein that binds to receptors of the Frizzled family. Wnt-4 is important for multiple embryonic development processes including kidney morphogenesis.
 Product Categories/Family for anti-WNT4 antibody    Antibodies; Abs to Wnt Proteins
 Applications Tested/Suitable for anti-WNT4 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-WNT4 antibody    Suitable for use in Direct ELISA and Western Blot.
Dilution: ELISA: 0.5-1.0ug/ml. The detection limit is ~1ng/well.
Western Blot: 5ug/ml. The detection limit is ~1ng/lane under non-reducing and reducing conditions.
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NCBI/Uniprot data below describe general gene information for WNT4. It may not necessarily be applicable to this product.
 NCBI GI #    13430197
 NCBI GeneID    54361
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 UniProt Primary Accession #    P56705 [Other Products]
 UniProt Secondary Accession #    Q5TZQ0; Q96T81; Q9BXF5; Q9H1J8; Q9UJM2 [Other Products]
 UniProt Related Accession #    P56705; Q5JYX2; Q8IUM6 [Other Products]
 Molecular Weight    39,052 Da [Similar Products]
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 NCBI Official Full Name    WNT4
 NCBI Official Synonym Full Names    wingless-type MMTV integration site family, member 4
 NCBI Official Symbol    WNT4 [Similar Products]
 NCBI Official Synonym Symbols   
WNT-4; SERKAL
[Similar Products]
 NCBI Protein Information    protein Wnt-4; OTTHUMP00000002937
 UniProt Protein Name    Protein Wnt-4
 UniProt Gene Name    WNT4 [Similar Products]
 UniProt Entry Name    WNT4_HUMAN
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 NCBI Summary for WNT4    The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq]
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 UniProt Comments for WNT4    WNT4: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Overexpression may be associated with abnormal proliferation in human breast tissue. Defects in WNT4 are a cause of Rokitansky-Kuster-Hauser syndrome (RKH syndrome); also called Mayer- Rokitansky-Kuster-Hauser syndrome (MRKH syndrome or MRKH anomaly). RKH syndrome is characterized by utero-vaginal atresia in otherwise phenotypically normal female with a normal 46,XX karyotype. Anomalies of the genital tract range from upper vaginal atresia to total Muellerian agenesis with urinary tract abnormalities. It has an incidence of approximately 1 in 5'000 newborn girls. Defects in WNT4 are the cause of female sex reversal with dysgenesis of kidneys, adrenals, and lungs (SERKAL); also known as SERKAL syndrome. Defects in WNT4 are the cause of Muellerian aplasia (MULLAPL). Belongs to the Wnt family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.23-p35.1

Cellular Component: proteinaceous extracellular matrix; extracellular space; cell surface; endoplasmic reticulum lumen; Golgi lumen; cytoplasm; plasma membrane; extracellular region

Molecular Function: frizzled binding; receptor agonist activity; transcription corepressor activity

Biological Process: negative regulation of fibroblast growth factor receptor signaling pathway; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; thyroid stimulating hormone secreting cell differentiation; androgen biosynthetic process; Wnt receptor signaling pathway through beta-catenin; somatotropin secreting cell differentiation; neuron differentiation; regulation of cell-cell adhesion; positive regulation of focal adhesion formation; positive regulation of aldosterone biosynthetic process; positive regulation of stress fiber formation; embryonic epithelial tube formation; kidney development; negative regulation of cell migration; female gonad development; cell fate commitment; positive regulation of meiosis; adrenal gland development; male gonad development; immature T cell proliferation in the thymus; cellular response to starvation; liver development; positive regulation of bone mineralization; positive regulation of osteoblast differentiation; negative regulation of cell differentiation; protein palmitoylation; ureteric bud branching; epithelial to mesenchymal transition; female sex determination; smooth muscle cell differentiation; negative regulation of transcription, DNA-dependent; oocyte development

Disease: Mullerian Aplasia And Hyperandrogenism; 46,xx Sex Reversal With Dysgenesis Of Kidneys, Adrenals, And Lungs
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 Research Articles on WNT4    1. These observations highlight the distinct roles of WNT11 and WNT4 during the early stages of retinoic acid-induced neuronal differentiation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-WNT4 antibodyPathways associated with anti-WNT4 antibody
 Reference Product  PubMed Publications
 SFRP2 antibody  >9 publications with WNT4 and SFRP2
 SFRP1 antibody  >7 publications with WNT4 and SFRP1
 FZD6 antibody  >4 publications with WNT4 and FZD6
 Products by Pathway  Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 DNA Damage Response (only ATM Dependent) Pathway antibodies  DNA Damage Response (only ATM Dependent) Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Melanogenesis Pathway antibodies  Melanogenesis Pathway Diagram
Diseases associated with anti-WNT4 antibodyOrgans/Tissues associated with anti-WNT4 antibody
 Disease Name  Pubmed Publications
 Female Urogenital Diseases Antibodies  >34 publications with WNT4 and Female Urogenital Diseases
 Male Urogenital Diseases Antibodies  >27 publications with WNT4 and Male Urogenital Diseases
 Congenital Abnormalities Antibodies  >26 publications with WNT4 and Congenital Abnormalities
 Neoplasms Antibodies  >23 publications with WNT4 and Neoplasms
 Gonadal Disorders Antibodies  >22 publications with WNT4 and Gonadal Disorders
 Carcinoma Antibodies  >9 publications with WNT4 and Carcinoma
 MAYER-ROKITANSKY-KUSTER-HAUSER SYNDROME Antibodies  >9 publications with WNT4 and MAYER-ROKITANSKY-KUSTER-HAUSER SYNDROME
 Breast Neoplasms Antibodies  >7 publications with WNT4 and Breast Neoplasms
 Fibrosis Antibodies  >6 publications with WNT4 and Fibrosis
 Liver Diseases Antibodies  >5 publications with WNT4 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >55 publications with WNT4 and Ovary
 Kidney Antibodies  >47 publications with WNT4 and Kidney
 Embryonic Tissue Antibodies  >42 publications with WNT4 and Embryonic Tissue
 Uterus Antibodies  >24 publications with WNT4 and Uterus
 Brain Antibodies  >20 publications with WNT4 and Brain
 Eye Antibodies  >8 publications with WNT4 and Eye
 Mammary Gland Antibodies  >7 publications with WNT4 and Mammary Gland
 Heart Antibodies  >4 publications with WNT4 and Heart
 Lung Antibodies  >4 publications with WNT4 and Lung
 Placenta Antibodies  >3 publications with WNT4 and Placenta
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