NP_000371
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
31,368 Da
NCBI Official Full Name
DNA repair protein complementing XP-A cells
NCBI Official Synonym Full Names
xeroderma pigmentosum, complementation group A
NCBI Official Synonym Symbols
NCBI Protein Information
DNA repair protein complementing XP-A cells; excision repair-controlling; mutant xeroderma pigmentosum complementation group A; xeroderma pigmentosum group A-complementing protein
UniProt Protein Name
DNA repair protein complementing XP-A cells
UniProt Synonym Protein Names
Xeroderma pigmentosum group A-complementing protein
UniProt Synonym Gene Names
UniProt Entry Name
XPA_HUMAN
NCBI Summary for XPA
This gene encodes a zinc finger protein involved in DNA excision repair. The encoded protein is part of the NER (nucleotide excision repair) complext which is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens. Mutations in this gene are associated with xeroderma pigmentosum complementation group A. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
UniProt Comments for XPA
XPA: Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation. Interacts with GPN1 and RPA1. Interacts (via N-terminus) with CEP164 upon UV irradiation. Interacts with HERC2. Expressed in various cell lines and in skin fibroblasts. Belongs to the XPA family.
Protein type: DNA repair, damage
Chromosomal Location of Human Ortholog: 9q22.3
Cellular Component: nucleoplasm; Golgi apparatus; intercellular bridge; DNA replication factor A complex; cytoplasm; nucleus
Molecular Function: protein domain specific binding; protein binding; protein homodimerization activity; metal ion binding; damaged DNA binding
Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; nucleotide-excision repair; multicellular organism growth; response to toxin; nucleotide-excision repair, DNA damage removal; response to oxidative stress; DNA repair; response to UV
Disease: Xeroderma Pigmentosum, Complementation Group A
Product References and Citations for anti-XPA antibody
Pan Y.R., et al. (2009) Cell Cycle 8:655-664
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Products associated with anti-XPA antibody
Pathways associated with anti-XPA antibody
Diseases associated with anti-XPA antibody
Organs/Tissues associated with anti-XPA antibody
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