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anti-XRCC1 antibody :: Mouse anti-Human, Rat XRCC1 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS602221 anti-XRCC1 antibody
Unit / Price
0.5 mL  /  $675 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

XRCC1, Monoclonal Antibody

 Also Known As   

XRCC1 (X-Ray Repair Cross Complementing Protein1)

 Product Synonym Names    Anti -XRCC1 (X-Ray Repair Cross Complementing Protein1)
 Product Gene Name   

anti-XRCC1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    Not determined
 Chromosome Location    Chromosome: 19; NC_000019.9 (44047464..44079730, complement). Location: 19q13.2
 OMIM    194360
 3D Structure    ModBase 3D Structure for P18887
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 Clonality    Monoclonal
 Isotype    IgG2b
 Clone Number    3F400
 Host    Mouse
 Species Reactivity    Human, Rat
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 Specificity    Recognizes XRCC1 (X-Ray Repair Cross Complementing Protein1). Species Crossreactivity: human and rat.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in 10mM PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide. Also available without BSA and azide. See X9501-01X
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 Immunogen    Recombinant human XRCC1 protein
 Cellular Localization    Nuclear
 Positive Control    Ls174T, HT29, or HeLa cells. Normal testis.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at-20 degree C or colder. Aliquots are stable for at least 12 months at-20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-XRCC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-XRCC1 antibody

   X-Ray Repair Cross Complementing (XRCC1) plays a role in excision repair of DNA after ionizing irradiation. XRCC1 binds to DNA ligase III through the C-terminal 96 amino acids and to DNA polymerase beta through the N-terminal half.. In testis XRCC1 is expressed at high levels. Cells with a mutation of this gene exhibit decreased single strand break repair and reduced recombination repair. They show increased double strand breaks, and sister chromatid exchange is increased up to 10-fold. The XRCC1 might serve as a scaffold protein during base excision-repair.
 Product Categories/Family for anti-XRCC1 antibody    Antibodies; Abs to Transcription Factors
 Applications Tested/Suitable for anti-XRCC1 antibody   

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

 Application Notes for anti-XRCC1 antibody    Dilution: Immunoprecipitation (Native verified) (Use Protein A) (Ab 2ug/mg protein lysate)
Western Blotting (Ab 1-2ug/ml for 2hrs at RT)
Immunohistochemistry (Formalin/paraffin) (1-2ug/ml for 30 min at RT; is better) * [Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 min.] The optimal dilution for a specific application should be determined by the investigator.
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NCBI/Uniprot data below describe general gene information for XRCC1. It may not necessarily be applicable to this product.
 NCBI GI #    48145573
 NCBI GeneID    7515
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 UniProt Primary Accession #    P18887 [Other Products]
 UniProt Secondary Accession #    Q6IBS4; Q9HCB1 [Other Products]
 UniProt Related Accession #    P18887; Q59HH7 [Other Products]
 Molecular Weight    85kD [Similar Products]
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 NCBI Official Full Name    XRCC1
 NCBI Official Synonym Full Names    X-ray repair complementing defective repair in Chinese hamster cells 1
 NCBI Official Symbol    XRCC1 [Similar Products]
 NCBI Official Synonym Symbols   
RCC
[Similar Products]
 NCBI Protein Information    DNA repair protein XRCC1; X-ray repair cross-complementing protein 1; X-ray-repair, complementing defective, repair in Chinese hamster
 UniProt Protein Name    DNA repair protein XRCC1
 UniProt Synonym Protein Names   
X-ray repair cross-complementing protein 1
 Protein Family    DNA repair protein
 UniProt Gene Name    XRCC1 [Similar Products]
 UniProt Entry Name    XRCC1_HUMAN
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 NCBI Summary for XRCC1    The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq]
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 UniProt Comments for XRCC1    XRCC1: Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts with APEX1; the interaction is induced by SIRT1 and increases with the acetylated form of APEX1.

Protein type: DNA repair, damage

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; enzyme binding; damaged DNA binding

Biological Process: single strand break repair; base-excision repair; DNA repair
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 Research Articles on XRCC1    1. XRCC1 codon 399 Gln/Gln genotype is associated with reduced susceptibility to CpG island hyper methylation especially DAP-kinase.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-XRCC1 antibodyPathways associated with anti-XRCC1 antibody
 Reference Product  PubMed Publications
 OGG1 antibody  >71 publications with XRCC1 and OGG1
 APEX1 antibody  >70 publications with XRCC1 and APEX1
 PARP1 antibody  >39 publications with XRCC1 and PARP1
 Products by Pathway  Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 FOXM1 Transcription Factor Network Pathway antibodies  FOXM1 Transcription Factor Network Pathway Diagram
 Resolution Of AP Sites Via The Single-nucleotide Replacement Pathway antibodies  Resolution Of AP Sites Via The Single-nucleotide Replacement Pathway Diagram
 Resolution Of Abasic Sites (AP Sites) Pathway antibodies  Resolution Of Abasic Sites (AP Sites) Pathway Diagram
Diseases associated with anti-XRCC1 antibodyOrgans/Tissues associated with anti-XRCC1 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >510 publications with XRCC1 and Neoplasms
 Carcinoma Antibodies  >189 publications with XRCC1 and Carcinoma
 Gastrointestinal Neoplasms Antibodies  >110 publications with XRCC1 and Gastrointestinal Neoplasms
 Lung Neoplasms Antibodies  >99 publications with XRCC1 and Lung Neoplasms
 Lung Diseases Antibodies  >98 publications with XRCC1 and Lung Diseases
 Skin Diseases Antibodies  >91 publications with XRCC1 and Skin Diseases
 Breast Neoplasms Antibodies  >84 publications with XRCC1 and Breast Neoplasms
 Urogenital Neoplasms Antibodies  >78 publications with XRCC1 and Urogenital Neoplasms
 Head and Neck Neoplasms Antibodies  >76 publications with XRCC1 and Head and Neck Neoplasms
 Adenocarcinoma Antibodies  >75 publications with XRCC1 and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >171 publications with XRCC1 and Blood
 Lung Antibodies  >126 publications with XRCC1 and Lung
 Bladder Antibodies  >41 publications with XRCC1 and Bladder
 Prostate Antibodies  >30 publications with XRCC1 and Prostate
 Ovary Antibodies  >28 publications with XRCC1 and Ovary
 Brain Antibodies  >27 publications with XRCC1 and Brain
 Liver Antibodies  >24 publications with XRCC1 and Liver
 Skin Antibodies  >22 publications with XRCC1 and Skin
 Thyroid Antibodies  >10 publications with XRCC1 and Thyroid
 Bone Antibodies  >10 publications with XRCC1 and Bone
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