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anti-XRCC5 antibody :: Mouse anti-Human XRCC5 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS120221
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

XRCC5, Monoclonal Antibody

★Popular Item★
 Also Known As   

Mouse monoclonal antibody Anti-Human XRCC5

 Product Synonym Names    Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining; Ku autoantigen, 80kDa) (XRCC5); KU80; KUB2; Ku86; NFIV;KARP1; KARP-1; FLJ39089
 Product Gene Name   

anti-XRCC5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    194364
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    3241C1a
 Host    Mouse
 Species Reactivity    Human
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 Concentration    100 ug/ml (1.0 ml) (lot specific)
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 Preparation    This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
 Sterility    Filtered through a 0.22 um membrane.
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 Other Notes    Small volumes of anti-XRCC5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-XRCC5 antibody

   The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [NCBI Entrez Gene Summary]
 Applications Tested/Suitable for anti-XRCC5 antibody   

Dot Blot (DB), Immunocytochemistry (ICC), Immunoprecipitation (IP), Western Blot (WB), Flow Cytometry (FC/FACS)

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 Quality Control of anti-XRCC5 antibody    Western blot analysis of immunized recombinant protein, using anti-XRCC5 monoclonal antibody.
anti-XRCC5 antibody Quality Control image
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 Quality Control #2 of anti-XRCC5 antibody    Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.
anti-XRCC5 antibody Quality Control #2 image
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 Western Blot (WB) of anti-XRCC5 antibody    Detection of human XRCC5 by Western blot.

Samples: Whole cell lysate (25 ug) from HEK293 cells. [Lot No. 3241C1a-1]

Predicted molecular weight: 82 kDa
anti-XRCC5 antibody Western Blot (WB) (WB) image
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 Immunoprecipitation (IP) of anti-XRCC5 antibody    Immunoprecipitation: RIPA lysate of HeLa cells was incubated with anti-XRCC5 mAb. [Lot No. 3241C1a-1]

Predicted molecular weight: 82 kDa
anti-XRCC5 antibody Immunoprecipitation (IP) (IP) image
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 Flow Cytometry (FC/FACS) of anti-XRCC5 antibody    HeLa cells were fixed in 2% paraformaldehyde/PBS and then permeabilized in 90% methanol. Cells were stained with anti-XRCC5 mAb (shaded) or isotype control (unshaded) followed by Alexa Fluor(R) 488-conjugated goat anti-mouse IgG. [Lot No. 3241C1a-1]
anti-XRCC5 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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 Immunocytochemistry (ICC) of anti-XRCC5 antibody    Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-XRCC5 mAb. [Lot No. 3241C1a-1]
anti-XRCC5 antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for XRCC5. It may not necessarily be applicable to this product.
 NCBI GI #    195963391
 NCBI GeneID    7520
 NCBI Accession #    NP_066964.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021141 [Other Products]
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 UniProt Secondary Accession #    Q0Z7V0; Q4VBQ5; Q53HH7; Q7M4N0; Q9UCQ0; Q9UCQ1; A8K3X5 [Other Products]
 UniProt Related Accession #    P13010 [Other Products]
 Molecular Weight    82,705 Da
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 NCBI Official Full Name    Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) (XRCC5), mRNA
 NCBI Official Synonym Full Names    X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
 NCBI Official Symbol    XRCC5 [Similar Products]
 NCBI Official Synonym Symbols   
KU80; KUB2; Ku86; NFIV; KARP1; KARP-1
[Similar Products]
 NCBI Protein Information    X-ray repair cross-complementing protein 5; 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; Ku autoantigen, 80kDa; Ku86 autoantigen related protein 1; TLAA; lupus Ku autoantigen protein p86; nuclear factor IV; thyroid-lupus autoantigen
 UniProt Protein Name    X-ray repair cross-complementing protein 5
 UniProt Synonym Protein Names   
86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; Ku80; Ku86; Lupus Ku autoantigen protein p86; Nuclear factor IV; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
 UniProt Gene Name    XRCC5 [Similar Products]
 UniProt Entry Name    XRCC5_HUMAN
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 NCBI Summary for XRCC5    The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
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 UniProt Comments for XRCC5    Ku80: the 80-kilodalton subunit of the Ku complex, also known as ATP-dependant DNA helicase II. A single stranded DNA-dependent ATP-dependent helicase. It functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by p70.

Protein type: RNA-binding; Nucleolus; EC 3.6.1.-; Helicase; Nuclear receptor co-regulator; EC 3.6.4.-; DNA-binding

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: nucleoplasm; nuclear telomere cap complex; nuclear chromosome, telomeric region; membrane; nucleolus; plasma membrane; nucleus; cytosol

Molecular Function: ATP-dependent DNA helicase activity; protein C-terminus binding; protein binding; DNA binding; ubiquitin protein ligase binding; double-stranded DNA binding; telomeric DNA binding; damaged DNA binding; double-stranded telomeric DNA binding; 5'-deoxyribose-5-phosphate lyase activity; ATP binding

Biological Process: response to drug; positive regulation of neurogenesis; transcription, DNA-dependent; viral reproduction; DNA repair; double-strand break repair via nonhomologous end joining; DNA duplex unwinding; DNA recombination; cell proliferation; double-strand break repair; positive regulation of interferon type I production; innate immune response; brain development; negative regulation of transcription, DNA-dependent; telomere maintenance
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 Research Articles on XRCC5    1. RECQL4 stimulates higher order DNA binding of Ku70/Ku80 to a blunt end DNA substrate. Taken together, these results implicate that RECQL4 participates in the NHEJ pathway of DSB repair via a functional interaction with the Ku70/Ku80 complex.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-XRCC5 antibodyPathways associated with anti-XRCC5 antibody
 Reference Product  PubMed Publications
 PRKDC antibody  >169 publications with XRCC5 and PRKDC
 XRCC4 antibody  >70 publications with XRCC5 and XRCC4
 XRCC6 antibody  >24 publications with XRCC5 and XRCC6
 WRN antibody  >18 publications with XRCC5 and WRN
 PCNA antibody  >15 publications with XRCC5 and PCNA
 LIG4 antibody  >14 publications with XRCC5 and LIG4
 PARP1 antibody  >5 publications with XRCC5 and PARP1
 NHEJ1 antibody  >4 publications with XRCC5 and NHEJ1
 APLF antibody  >3 publications with XRCC5 and APLF
 Products by Pathway  Pathway Diagram
 2-LTR Circle Formation Pathway antibodies  2-LTR Circle Formation Pathway Diagram
 BARD1 Signaling Events Pathway antibodies  BARD1 Signaling Events Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 DNA-PK Complex Pathway antibodies  DNA-PK Complex Pathway Diagram
 DNA-PK Complex Pathway antibodies  DNA-PK Complex Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Double-Strand Break Repair Pathway antibodies  Double-Strand Break Repair Pathway Diagram
 Early Phase Of HIV Life Cycle Pathway antibodies  Early Phase Of HIV Life Cycle Pathway Diagram
Diseases associated with anti-XRCC5 antibodyOrgans/Tissues associated with anti-XRCC5 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >50 publications with XRCC5 and Carcinoma
 Nervous System Diseases Antibodies  >42 publications with XRCC5 and Nervous System Diseases
 Leukemia Antibodies  >24 publications with XRCC5 and Leukemia
 Lung Diseases Antibodies  >17 publications with XRCC5 and Lung Diseases
 Neoplasms, Experimental Antibodies  >15 publications with XRCC5 and Neoplasms, Experimental
 Breast Neoplasms Antibodies  >15 publications with XRCC5 and Breast Neoplasms
 Adenocarcinoma Antibodies  >14 publications with XRCC5 and Adenocarcinoma
 Liver Diseases Antibodies  >14 publications with XRCC5 and Liver Diseases
 Lung Neoplasms Antibodies  >12 publications with XRCC5 and Lung Neoplasms
 Glioma Antibodies  >11 publications with XRCC5 and Glioma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >98 publications with XRCC5 and Blood
 Brain Antibodies  >30 publications with XRCC5 and Brain
 Liver Antibodies  >25 publications with XRCC5 and Liver
 Ovary Antibodies  >25 publications with XRCC5 and Ovary
 Lung Antibodies  >24 publications with XRCC5 and Lung
 Skin Antibodies  >12 publications with XRCC5 and Skin
 Bone Antibodies  >11 publications with XRCC5 and Bone
 Kidney Antibodies  >10 publications with XRCC5 and Kidney
 Testis Antibodies  >10 publications with XRCC5 and Testis
 Bone Marrow Antibodies  >9 publications with XRCC5 and Bone Marrow
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