NP_003671.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Homo sapiens tyrosyl-tRNA synthetase (YARS), mRNA
NCBI Official Synonym Full Names
tyrosyl-tRNA synthetase
NCBI Protein Information
tyrosine--tRNA ligase, cytoplasmic; tyrosine tRNA ligase 1, cytoplasmic; tyrosyl--tRNA ligase; tyrosyl-tRNA synthetase, cytoplasmic
UniProt Protein Name
Tyrosine--tRNA ligase, cytoplasmic
UniProt Synonym Protein Names
Tyrosyl-tRNA synthetase; TyrRS
UniProt Entry Name
SYYC_HUMAN
NCBI Summary for YARS
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]
UniProt Comments for YARS
YARS: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr). Defects in YARS are the cause of Charcot-Marie-Tooth disease dominant intermediate type C (CMTDIC). CMTDIC is a form of Charcot-Marie-Tooth disease characterized by clinical and pathologic features intermediate between demyelinating and axonal peripheral neuropathies, and motor median nerve conduction velocities ranging from 25 to 45 m/sec. Belongs to the class-I aminoacyl-tRNA synthetase family.
Protein type: EC 6.1.1.1; Ligase
Chromosomal Location of Human Ortholog: 1p35.1
Cellular Component: extracellular space; cytoplasm; nucleus; cytosol
Molecular Function: signal transducer activity; tyrosine-tRNA ligase activity; ATP binding; interleukin-8 receptor binding; isoleucine-tRNA ligase activity; tRNA binding
Biological Process: tyrosyl-tRNA aminoacylation; isoleucyl-tRNA aminoacylation; tRNA aminoacylation for protein translation; apoptosis; gene expression; signal transduction
Disease: Charcot-marie-tooth Disease, Dominant Intermediate C
Research Articles on YARS
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Products associated with anti-YARS antibody
Pathways associated with anti-YARS antibody
Diseases associated with anti-YARS antibody
Organs/Tissues associated with anti-YARS antibody
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