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anti-ZAP 70 antibody :: Mouse ZAP 70 Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS211479 anti-ZAP 70 antibody
Unit / Price
0.025 mg  /  $215 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ZAP 70, Monoclonal Antibody

 Also Known As   

MOUSE ANTI HUMAN ZAP 70

 Product Gene Name   

anti-ZAP 70 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    176947
 3D Structure    ModBase 3D Structure for P43403
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    SBZAP
 Host    Mouse
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 Form/Format    Purified
Purified IgG - liquid
 Concentration    Approximate Protein Concentration: 0.1 mg/ml (lot specific)
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 Buffer Solution    Borate buffered saline
 Target Species    Human
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 Preparation and Storage    At -20 degree C only (ship 4 degree C)
Shelf Life: 18 months from the date of despatch.
 Other Notes    Small volumes of anti-ZAP 70 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ZAP 70 antibody

   Mouse anti Human ZAP 70 antibody, clone SBZAP recognizes human ZAP-70, a 70kDa tyrosine protein kinase which associates with the T-cell receptor (TCR) zeta chain and undergoes phosphorylation following TCR stimulation. ZAP-70 is primarily expressed in T lymphocytes and natural killer cells, where it plays a key role in T-cell receptor (TCR) signalling. Recent studies suggest that ZAP-70 is also expressed in a population of normal immature B-cells and in B-cells from a sub-set of patients with chronic lymphocytic leukaemia.
 Applications Tested/Suitable for anti-ZAP 70 antibody   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for ZAP 70. It may not necessarily be applicable to this product.
 NCBI GI #    31455611
 NCBI GeneID    7535
 NCBI Accession #    NP_001070.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001079.3 [Other Products]
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 UniProt Primary Accession #    P43403 [Other Products]
 UniProt Secondary Accession #    Q6PIA4; Q8IXD6; Q9UBS6; A6NFP4 [Other Products]
 UniProt Related Accession #    P43403 [Other Products]
 Molecular Weight    55,873 Da
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 NCBI Official Full Name    tyrosine-protein kinase ZAP-70 isoform 1
 NCBI Official Synonym Full Names    zeta-chain (TCR) associated protein kinase 70kDa
 NCBI Official Symbol    ZAP70 [Similar Products]
 NCBI Official Synonym Symbols   
SRK; STD; TZK; STCD; ZAP-70
[Similar Products]
 NCBI Protein Information    tyrosine-protein kinase ZAP-70; 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; syk-related tyrosine kinase; zeta-chain associated protein kinase, 70kD
 UniProt Protein Name    Tyrosine-protein kinase ZAP-70
 UniProt Synonym Protein Names   
70 kDa zeta-chain associated protein; Syk-related tyrosine kinase
 UniProt Gene Name    ZAP70 [Similar Products]
 UniProt Synonym Gene Names    SRK [Similar Products]
 UniProt Entry Name    ZAP70_HUMAN
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 NCBI Summary for ZAP 70    This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ZAP 70    ZAP70: a tyrosine kinase of the Syk family. Associates with the T-cell antigen receptor zeta-chain after TCR stimulation. Phosphorylated by Src-family kinases following antigen receptor activation. Plays a role in lymphocyte activation.

Protein type: Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Protein kinase, TK; Kinase, protein; TK group; Syk family

Chromosomal Location of Human Ortholog: 2q12

Cellular Component: T cell receptor complex; extrinsic to internal side of plasma membrane; cytoplasm; plasma membrane; immunological synapse; intercellular junction; cytosol; lipid raft

Molecular Function: protein binding; phosphotyrosine binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding

Biological Process: cell migration; adaptive immune response; peptidyl-tyrosine phosphorylation; B cell activation; T cell activation; positive regulation of calcium-mediated signaling; negative thymic T cell selection; T cell receptor signaling pathway; protein amino acid phosphorylation; positive regulation of T cell differentiation; innate immune response; immune response; beta selection; positive regulation of alpha-beta T cell proliferation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of alpha-beta T cell differentiation; T cell differentiation; positive thymic T cell selection

Disease: Selective T-cell Defect
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 Research Articles on ZAP 70    1. The corrected mean fluorescence intensity (CorrMFI) represents the most promising method currently available in a routine diagnostic setting for the assessment of ZAP-70 expression in CLL patients.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ZAP 70 antibodyPathways associated with anti-ZAP 70 antibody
 Reference Product  PubMed Publications
 LCK antibody  >280 publications with ZAP 70 and LCK
 LAT antibody  >121 publications with ZAP 70 and LAT
 VAV1 antibody  >48 publications with ZAP 70 and VAV1
 CBL antibody  >48 publications with ZAP 70 and CBL
 PTPN6 antibody  >22 publications with ZAP 70 and PTPN6
 CD3E antibody  >16 publications with ZAP 70 and CD3E
 SHC1 antibody  >12 publications with ZAP 70 and SHC1
 CD247 antibody  >3 publications with ZAP 70 and CD247
 LCP2 antibody  >1 publications with ZAP 70 and LCP2
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Generation Of Second Messenger Molecules Pathway antibodies  Generation Of Second Messenger Molecules Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammatory Response Pathway antibodies  Inflammatory Response Pathway Diagram
 Interferon Type I Pathway antibodies  Interferon Type I Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram
 Primary Immunodeficiency Pathway antibodies  Primary Immunodeficiency Pathway Diagram
Diseases associated with anti-ZAP 70 antibodyOrgans/Tissues associated with anti-ZAP 70 antibody
 Disease Name  Pubmed Publications
 Immunologic Deficiency Syndromes Antibodies  >66 publications with ZAP 70 and Immunologic Deficiency Syndromes
 Severe Combined Immunodeficiency Antibodies  >42 publications with ZAP 70 and Severe Combined Immunodeficiency
 Inflammation Antibodies  >32 publications with ZAP 70 and Inflammation
 Necrosis Antibodies  >25 publications with ZAP 70 and Necrosis
 Neoplasms, Experimental Antibodies  >8 publications with ZAP 70 and Neoplasms, Experimental
 Anemia Antibodies  >5 publications with ZAP 70 and Anemia
 Congenital Abnormalities Antibodies  >5 publications with ZAP 70 and Congenital Abnormalities
 Kidney Diseases Antibodies  >4 publications with ZAP 70 and Kidney Diseases
 Weight Loss Antibodies  >3 publications with ZAP 70 and Weight Loss
 Hepatomegaly Antibodies  >2 publications with ZAP 70 and Hepatomegaly
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >828 publications with ZAP 70 and Blood
 Thymus Antibodies  >71 publications with ZAP 70 and Thymus
 Bone Marrow Antibodies  >65 publications with ZAP 70 and Bone Marrow
 Spleen Antibodies  >45 publications with ZAP 70 and Spleen
 Lymph Node Antibodies  >36 publications with ZAP 70 and Lymph Node
 Intestine Antibodies  >7 publications with ZAP 70 and Intestine
 Liver Antibodies  >7 publications with ZAP 70 and Liver
 Brain Antibodies  >6 publications with ZAP 70 and Brain
 Kidney Antibodies  >4 publications with ZAP 70 and Kidney
 Mammary Gland Antibodies  >2 publications with ZAP 70 and Mammary Gland
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