NP_001070.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
55,873 Da
NCBI Official Full Name
tyrosine-protein kinase ZAP-70 isoform 1
NCBI Official Synonym Full Names
zeta-chain (TCR) associated protein kinase 70kDa
NCBI Protein Information
tyrosine-protein kinase ZAP-70; syk-related tyrosine kinase; 70 kDa zeta-associated protein; 70 kDa zeta-chain associated protein; zeta-chain associated protein kinase, 70kD
UniProt Protein Name
Tyrosine-protein kinase ZAP-70
UniProt Synonym Protein Names
70 kDa zeta-chain associated protein; Syk-related tyrosine kinase
UniProt Synonym Gene Names
UniProt Entry Name
ZAP70_HUMAN
NCBI Summary for ZAP70
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ZAP70
ZAP70: a tyrosine kinase of the Syk family. Associates with the T-cell antigen receptor zeta-chain after TCR stimulation. Phosphorylated by Src-family kinases following antigen receptor activation. Plays a role in lymphocyte activation.
Protein type: Kinase, protein; Protein kinase, tyrosine (non-receptor); EC 2.7.10.2; Protein kinase, TK; TK group; Syk family
Chromosomal Location of Human Ortholog: 2q12
Cellular Component: T cell receptor complex; extrinsic to internal side of plasma membrane; cytoplasm; plasma membrane; immunological synapse; intercellular junction; cytosol; lipid raft
Molecular Function: protein binding; phosphotyrosine binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding
Biological Process: cell migration; adaptive immune response; peptidyl-tyrosine phosphorylation; T cell activation; B cell activation; positive regulation of calcium-mediated signaling; negative thymic T cell selection; T cell receptor signaling pathway; protein amino acid phosphorylation; positive regulation of T cell differentiation; innate immune response; beta selection; positive regulation of alpha-beta T cell proliferation; immune response; positive regulation of alpha-beta T cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; positive thymic T cell selection; T cell differentiation
Disease: Selective T-cell Defect
Research Articles on ZAP70
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Products associated with anti-ZAP70 antibody
Pathways associated with anti-ZAP70 antibody
Diseases associated with anti-ZAP70 antibody
Organs/Tissues associated with anti-ZAP70 antibody
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