NP_056956.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
61,584 Da
NCBI Official Synonym Full Names
zinc finger and BTB domain containing 7B
NCBI Official Synonym Symbols
CKROX; THPOK; ZFP67; ZBTB15; ZFP-67; c-KROX; hcKROX; ZNF857B [Similar Products]
NCBI Protein Information
zinc finger and BTB domain-containing protein 7B
UniProt Protein Name
Zinc finger and BTB domain-containing protein 7B
UniProt Synonym Protein Names
Krueppel-related zinc finger protein cKrox; hcKrox; T-helper-inducing POZ/Krueppel-like factor; Zinc finger and BTB domain-containing protein 15; Zinc finger protein 67 homolog; Zfp-67; Zinc finger protein 857B; Zinc finger protein Th-POK
UniProt Synonym Gene Names
UniProt Entry Name
ZBT7B_HUMAN
NCBI Summary for ZBTB7B
This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
UniProt Comments for ZBTB7B
ZBTB7B: Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes.
Protein type: C2H2-type zinc finger protein
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component: nucleoplasm; nucleus
Molecular Function: DNA binding; metal ion binding
Biological Process: transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; multicellular organismal development; ectoderm development; cell differentiation
Research Articles on ZBTB7B
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Products associated with anti-ZBTB7B antibody
Diseases associated with anti-ZBTB7B antibody
Organs/Tissues associated with anti-ZBTB7B antibody
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