P37275
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
zinc finger E-box binding homeobox 1
NCBI Official Synonym Full Names
zinc finger E-box binding homeobox 1
NCBI Official Synonym Symbols
BZP; TCF8; AREB6; FECD6; NIL2A; PPCD3; ZFHEP; ZFHX1A; DELTAEF1; MGC133261 [Similar Products]
NCBI Protein Information
zinc finger E-box-binding homeobox 1; OTTHUMP00000019404; OTTHUMP00000019405; OTTHUMP00000019406; negative regulator of IL2; delta-crystallin enhancer binding factor 1; posterior polymorphous corneal dystrophy 3; zinc finger homeodomain enhancer-binding protein; transcription factor 8 (represses interleukin 2 expression)
UniProt Protein Name
Zinc finger E-box-binding homeobox 1
UniProt Synonym Protein Names
NIL-2-A zinc finger protein; Negative regulator of IL2; Transcription factor 8
UniProt Synonym Gene Names
UniProt Entry Name
ZEB1_HUMAN
NCBI Summary for ZEB1
This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.
UniProt Comments for ZEB1
TCF8: Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Interacts (via N-terminus) with SMARCA4/BRG1. Colocalizes with SMARCA4/BRG1 in E-cadherin- negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas. Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas. Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.
Protein type: Transcription, coactivator/corepressor; DNA-binding; C2H2-type zinc finger protein; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10p11.2
Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus
Molecular Function: protein binding; zinc ion binding; transcription coactivator activity; double-stranded DNA binding; chromatin binding; transcription corepressor activity; transcription factor activity; transcription factor binding
Biological Process: response to nutrient levels; transcription, DNA-dependent; regulation of T cell differentiation in the thymus; semicircular canal morphogenesis; negative regulation of epithelial cell differentiation; negative regulation of transcription from RNA polymerase II promoter; pattern specification process; embryonic skeletal morphogenesis; regulation of mesenchymal cell proliferation; regulation of transcription from RNA polymerase II promoter; cell proliferation; negative regulation of cell proliferation; regulation of transforming growth factor beta receptor signaling pathway; cartilage development; regulation of smooth muscle cell differentiation; forebrain development; positive regulation of transcription from RNA polymerase II promoter; immune response; response to activity; embryonic camera-type eye morphogenesis; positive regulation of neuron differentiation; negative regulation of transcription, DNA-dependent
Disease: Corneal Dystrophy, Posterior Polymorphous, 3; Corneal Dystrophy, Fuchs Endothelial, 6
Research Articles on ZEB1
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Products associated with anti-ZEB1 antibody
Pathways associated with anti-ZEB1 antibody
Diseases associated with anti-ZEB1 antibody
Organs/Tissues associated with anti-ZEB1 antibody
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