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anti-ACTA1 antibody :: Mouse a-Actin, Skeletal Muscle Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS602996 anti-ACTA1 antibody
Unit / Price
0.5 mL  /  $545 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

a-Actin, Skeletal Muscle (ACTA1), Monoclonal Antibody

★Popular Item★
 Also Known As   

a-Actin, Skeletal Muscle

 Product Synonym Names    Anti -a-Actin, Skeletal Muscle
 Product Gene Name   

anti-ACTA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_006090.3 (39337939..39339803, complement). Location: chromosome: 3
 3D Structure    ModBase 3D Structure for P68139
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 Clonality    Monoclonal
 Isotype    IgM,k
 Clone Number    0.N.4
 Host    Mouse
 Species Reactivity    Bovine, Frog, Guinea Pig, Human, Rabbit, Rat, Sheep
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 Specificity    Recognizes human alpha-skeletal and alpha-cardiac (sarcomeric) actins as well as neoplasms derived from normal tissues (i.e. rhabdomyosarcomas). Shows no crossreaction with smooth muscle actin. Species Crossreactivity: bovine, rabbit, sheep, rat, guinea pig and frog.
 Purity/Purification    Purified
Purified by ammonium sulfate precipitation.
 Form/Format    Supplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide, before the addition of glycerol to 40%. Also available without BSA and azide. See A0760-24X.
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 Immunogen    N-terminal decapeptide of alpha skeletal muscle isoform of actin; acetylated at the N-terminus. Cellular Localization: Cytoplasmic. Epitope: N-terminal decapeptide.
 Positive Control    Skeletal or Cardiac muscle, or Rhabdomyosarcoma
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-ACTA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ACTA1 antibody    Antibodies; Abs to Actin Related Proteins
 Applications Tested/Suitable for anti-ACTA1 antibody   

Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-ACTA1 antibody    Suitable for use in Immunofluorescence and Immunohistochemistry.
Dilution: Immunohistochemistry (formalin/paraffin sections): 1:200 for 20 min at RT. No special pretreatment is required for the immunohistochemical staining of formalin/paraffin tissues.
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NCBI/Uniprot data below describe general gene information for ACTA1. It may not necessarily be applicable to this product.
 NCBI GI #    71894831
 NCBI GeneID    421534
 NCBI Accession #    NP_001026234.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001031063.1 [Other Products]
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 UniProt Primary Accession #    P68139 [Other Products]
 UniProt Secondary Accession #    P02568; P99020 [Other Products]
 UniProt Related Accession #    P68139 [Other Products]
 Molecular Weight    42,051 Da [Similar Products]
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 NCBI Official Full Name    actin, alpha skeletal muscle
 NCBI Official Synonym Full Names    actin, alpha 1, skeletal muscle
 NCBI Official Symbol    ACTA1 [Similar Products]
 NCBI Protein Information    actin, alpha skeletal muscle; a-actin; alpha-actin-1
 UniProt Protein Name    Actin, alpha skeletal muscle
 UniProt Synonym Protein Names   
Alpha-actin-1
 UniProt Gene Name    ACTA1 [Similar Products]
 UniProt Synonym Gene Names    ACTA [Similar Products]
 UniProt Entry Name    ACTS_CHICK
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 UniProt Comments for ACTA1    Function: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.

Subunit structure: Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others.

Subcellular location: Cytoplasm › cytoskeleton.

Post-translational modification: Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization

By similarity.

Miscellaneous: In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.

Sequence similarities: Belongs to the actin family.
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 Research Articles on ACTA1    1. These data suggest that actin bundling may improve the ability of the myosin motor system for nanotransport applications.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-ACTA1 antibodyOrgans/Tissues associated with anti-ACTA1 antibody
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >78 publications with ACTA1 and Nervous System Diseases
 MYOPATHY, CONGENITAL, WITH FIBER-TYPE DISPROPORTION Antibodies  >60 publications with ACTA1 and MYOPATHY, CONGENITAL, WITH FIBER-TYPE DISPROPORTION
 Nemaline myopathy 3 Antibodies  >16 publications with ACTA1 and Nemaline myopathy 3
 Hypertrophy Antibodies  >14 publications with ACTA1 and Hypertrophy
 Heart Diseases Antibodies  >14 publications with ACTA1 and Heart Diseases
 Cardiovascular Diseases Antibodies  >12 publications with ACTA1 and Cardiovascular Diseases
 Atrophy Antibodies  >7 publications with ACTA1 and Atrophy
 Fibrosis Antibodies  >6 publications with ACTA1 and Fibrosis
 Fetal Death Antibodies  >3 publications with ACTA1 and Fetal Death
 Hepatomegaly Antibodies  >2 publications with ACTA1 and Hepatomegaly
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >109 publications with ACTA1 and Muscle
 Heart Antibodies  >22 publications with ACTA1 and Heart
 Brain Antibodies  >9 publications with ACTA1 and Brain
 Embryonic Tissue Antibodies  >6 publications with ACTA1 and Embryonic Tissue
 Head Antibodies  >5 publications with ACTA1 and Head
 Adipose Tissue Antibodies  >1 publications with ACTA1 and Adipose Tissue
 Uncharacterized Tissue Antibodies  >1 publications with ACTA1 and Uncharacterized Tissue
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