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anti-NR5A2 antibody :: Mouse anti-Human a-Fetoprotein Receptor Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS602928 anti-NR5A2 antibody
Unit / Price
0.2 mg  /  $455 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

a-Fetoprotein Receptor (NR5A2), Monoclonal Antibody

★Popular Item★
 Also Known As   

a-Fetoprotein Receptor (AFPr)

 Product Synonym Names    Anti -a-Fetoprotein Receptor (AFPr)
 Product Gene Name   

anti-NR5A2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (199996730..200146552). Location: 1q32.1
 OMIM    604453
 3D Structure    ModBase 3D Structure for O00482
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 Clonality    Monoclonal
 Isotype    IgG2a
 Clone Number    4i264
 Host    Mouse
 Species Reactivity    Human
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 Specificity    Recognizes different determinants of human alpha-fetoprotein receptor. Blocks alpha-fetoprotein and it's receptor.
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
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 Immunogen    Purified, full-length, native human alpha fetoprotein receptor
 Positive Control    Ovarian adenocarcinoma SKOV3, human mammary carcinoma MCF-7, human cervical carcinoma Hela, B-cell lymphoma Raji and T-cell lymphoma Jurkat.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-NR5A2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-NR5A2 antibody

   AFP's cell growth-regulatory effects are mediated by its specific plasma membrane receptors coupled with its transmembrane signaling transduction through the pathway of cAMP-PKA and intracellular calcium to regulate the expression of oncogenes. The properties of the AFP receptor as well as the subsequent events after AFP binding are still undefined.
 Product Categories/Family for anti-NR5A2 antibody    Antibodies; Abs to Receptors
 Applications Tested/Suitable for anti-NR5A2 antibody   

Immunocytochemistry (ICC)

 Application Notes for anti-NR5A2 antibody    Suitable for use in Immunocytochemistry and Blocking studies.
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NCBI/Uniprot data below describe general gene information for NR5A2. It may not necessarily be applicable to this product.
 NCBI GI #    1947098
 NCBI GeneID    2494
 NCBI Accession #    AAD03155.1 [Other Products]
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 UniProt Primary Accession #    O00482 [Other Products]
 UniProt Secondary Accession #    O95642; Q147U3 [Other Products]
 UniProt Related Accession #    O00482 [Other Products]
 Molecular Weight    61,331 Da [Similar Products]
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 NCBI Official Full Name    alpha1-fetoprotein transcription factor
 NCBI Official Synonym Full Names    nuclear receptor subfamily 5, group A, member 2
 NCBI Official Symbol    NR5A2 [Similar Products]
 NCBI Official Synonym Symbols   
B1F; CPF; FTF; B1F2; LRH1; LRH-1; FTZ-F1; hB1F-2; FTZ-F1beta
[Similar Products]
 NCBI Protein Information    nuclear receptor subfamily 5 group A member 2; nuclear receptor NR5A2; liver receptor homolog 1; liver receptor homolog-1; CYP7A promoter-binding factor; hepatocytic transcription factor; alpha-1-fetoprotein transcription factor; liver nuclear receptor homolog-1 variant 2; fetoprotein-alpha 1 (AFP) transcription factor; b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus
 UniProt Protein Name    Nuclear receptor subfamily 5 group A member 2
 UniProt Synonym Protein Names   
Alpha-1-fetoprotein transcription factor; B1-binding factor; hB1F; CYP7A promoter-binding factor; Hepatocytic transcription factor; Liver receptor homolog 1
 Protein Family    Nuclear receptor subfamily
 UniProt Gene Name    NR5A2 [Similar Products]
 UniProt Synonym Gene Names    B1F; CPF; FTF; hB1F; LRH-1 [Similar Products]
 UniProt Entry Name    NR5A2_HUMAN
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 UniProt Comments for NR5A2    NR5A2: Binds to the sequence element 5'-AACGACCGACCTTGAG-3' of the enhancer II of hepatitis B virus genes, a critical cis-element of their expression and regulation. May be responsible for the liver-specific activity of enhancer II, probably in combination with other hepatocyte transcription factors. Key regulator of cholesterol 7-alpha-hydroxylase gene (CYP7A) expression in liver. May also contribute to the regulation of pancreas-specific genes and play important roles in embryonic development. Belongs to the nuclear hormone receptor family. NR5 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; ligand-dependent nuclear receptor activity; protein binding; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; phospholipid binding; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; positive regulation of viral genome replication; intracellular receptor-mediated signaling pathway; bile acid metabolic process; positive regulation of transcription, DNA-dependent; endocrine pancreas development; regulation of cell proliferation; cholesterol homeostasis; embryonic development; regulation of transcription, DNA-dependent; homeostatic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling
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 Research Articles on NR5A2    1. Data indicate that sequence divergence has differentially impacted ligand binding and protein dynamics in NR5A2.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-NR5A2 antibodyPathways associated with anti-NR5A2 antibody
 Reference Product  PubMed Publications
 CYP19A1 antibody  >38 publications with NR5A2 and CYP19A1
 CYP7A1 antibody  >19 publications with NR5A2 and CYP7A1
 STAR antibody  >12 publications with NR5A2 and STAR
 CTNNB1 antibody  >7 publications with NR5A2 and CTNNB1
 NR0B2 antibody  >6 publications with NR5A2 and NR0B2
 HSD3B2 antibody  >5 publications with NR5A2 and HSD3B2
 CR2 antibody  >1 publications with NR5A2 and CR2
 ABCB11 antibody  >1 publications with NR5A2 and ABCB11
 GPS2 antibody  >1 publications with NR5A2 and GPS2
 Products by Pathway  Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Maturity Onset Diabetes Of The Young Pathway antibodies  Maturity Onset Diabetes Of The Young Pathway Diagram
 Maturity Onset Diabetes Of The Young Pathway antibodies  Maturity Onset Diabetes Of The Young Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 Regulation Of Beta-cell Development Pathway antibodies  Regulation Of Beta-cell Development Pathway Diagram
 Regulation Of Gene Expression In Early Pancreatic Precursor Cells Pathway antibodies  Regulation Of Gene Expression In Early Pancreatic Precursor Cells Pathway Diagram
Diseases associated with anti-NR5A2 antibodyOrgans/Tissues associated with anti-NR5A2 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >44 publications with NR5A2 and Neoplasms
 Liver Neoplasms Antibodies  >28 publications with NR5A2 and Liver Neoplasms
 Liver Diseases Antibodies  >26 publications with NR5A2 and Liver Diseases
 Breast Neoplasms Antibodies  >14 publications with NR5A2 and Breast Neoplasms
 Inflammation Antibodies  >11 publications with NR5A2 and Inflammation
 Fatty Liver Antibodies  >11 publications with NR5A2 and Fatty Liver
 Pancreatic Neoplasms Antibodies  >8 publications with NR5A2 and Pancreatic Neoplasms
 Disease Models, Animal Antibodies  >7 publications with NR5A2 and Disease Models, Animal
 Infertility, Female Antibodies  >7 publications with NR5A2 and Infertility, Female
 Carcinoma, Hepatocellular Antibodies  >6 publications with NR5A2 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >175 publications with NR5A2 and Liver
 Testis Antibodies  >20 publications with NR5A2 and Testis
 Pancreas Antibodies  >20 publications with NR5A2 and Pancreas
 Embryonic Tissue Antibodies  >19 publications with NR5A2 and Embryonic Tissue
 Intestine Antibodies  >19 publications with NR5A2 and Intestine
 Brain Antibodies  >15 publications with NR5A2 and Brain
 Adrenal Gland Antibodies  >12 publications with NR5A2 and Adrenal Gland
 Kidney Antibodies  >6 publications with NR5A2 and Kidney
 Lung Antibodies  >4 publications with NR5A2 and Lung
 Muscle Antibodies  >4 publications with NR5A2 and Muscle
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