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anti-ACTN1 antibody :: Mouse a-actinin Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2548904
Immunohistochemistry (IHC)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

a-actinin (ACTN1), Monoclonal Antibody

 Also Known As   

a-actinin Monoclonal Antibody

 Product Gene Name   

anti-ACTN1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    X15804 mRNA
 3D Structure    ModBase 3D Structure for P12814
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 Clonality    Monoclonal
 Isotype    IgG
 Clone Number    1D4
 Host    Mouse
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Protein A Purification
 Concentration    1mg/mL (lot specific)
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 Immunogen    Recombinant Protein of a-actinin of ACTN1
 Buffer    PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
 Conjugation    Unconjugated
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ACTN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ACTN1 antibody

   Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
 Applications Tested/Suitable for anti-ACTN1 antibody   

Immunohistochemistry (IHC) Paraffin (IHC-p)

 Application Notes for anti-ACTN1 antibody    IHC: 1:100-200
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 Immunohistochemistry (IHC) of anti-ACTN1 antibody    Immunohistochemistry of paraffin-embedded Human kidney tissue using a-actinin Monoclonal Antibody at dilution of 1:200.
anti-ACTN1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ACTN1. It may not necessarily be applicable to this product.
 NCBI GI #    4501891
 NCBI GeneID    87
 NCBI Accession #    NP_001093.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001102.3 [Other Products]
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 UniProt Primary Accession #    P12814 [Other Products]
 UniProt Secondary Accession #    Q1HE25; Q9BTN1; B3V8S3; B4DHH3; B7TY16 [Other Products]
 UniProt Related Accession #    P12814 [Other Products]
 Molecular Weight    107,141 Da
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 NCBI Official Full Name    alpha-actinin-1 isoform b
 NCBI Official Synonym Full Names    actinin alpha 1
 NCBI Official Symbol    ACTN1 [Similar Products]
 NCBI Official Synonym Symbols   
BDPLT15
[Similar Products]
 NCBI Protein Information    alpha-actinin-1
 UniProt Protein Name    Alpha-actinin-1
 UniProt Synonym Protein Names   
Alpha-actinin cytoskeletal isoform; F-actin cross-linking protein; Non-muscle alpha-actinin-1
 Protein Family    Alpha-actinin
 UniProt Gene Name    ACTN1 [Similar Products]
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 NCBI Summary for ACTN1    Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ACTN1    ACTN1: a cytoskeletal protein of the spectrin superfamily. An actin-binding protein with multiple roles in different cell types. A nonmuscle isoform structurally similar to the erythroid beta spectrin gene.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 14q24.1|14q22-q24

Cellular Component: actin filament; brush border; cell projection; cytoplasm; cytosol; extracellular exosome; extracellular region; extracellular space; fascia adherens; focal adhesion; intercellular junction; intracellular; plasma membrane; pseudopodium; ruffle; stress fiber; Z disc

Molecular Function: actin filament binding; calcium ion binding; double-stranded RNA binding; integrin binding; ion channel binding; ligand-dependent nuclear receptor transcription coactivator activity; protein binding; protein homodimerization activity; vinculin binding

Biological Process: actin crosslink formation; actin filament bundle formation; actin filament network formation; actin filament organization; focal adhesion assembly; negative regulation of cell motility; platelet activation; platelet degranulation; platelet formation; regulation of apoptosis

Disease: Bleeding Disorder, Platelet-type, 15
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 Research Articles on ACTN1    1. our 11 patients with macrothrombocytopenia related to ACTN1 mutation are characterized by an isolated autosomal dominant mild thrombocytopenia, with low bleeding tendency.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ACTN1 antibodyPathways associated with anti-ACTN1 antibody
 Reference Product  PubMed Publications
 SRC antibody  >3 publications with ACTN1 and SRC
 VCL antibody  >2 publications with ACTN1 and VCL
 PTK2 antibody  >2 publications with ACTN1 and PTK2
 ZYX antibody  >1 publications with ACTN1 and ZYX
 SLC2A4 antibody  >1 publications with ACTN1 and SLC2A4
 PDLIM1 antibody  >1 publications with ACTN1 and PDLIM1
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-extracellular Matrix Interactions Pathway antibodies  Cell-extracellular Matrix Interactions Pathway Diagram
Diseases associated with anti-ACTN1 antibodyOrgans/Tissues associated with anti-ACTN1 antibody
 Disease Name  Pubmed Publications
 Colonic Neoplasms Antibodies  >5 publications with ACTN1 and Colonic Neoplasms
 Nervous System Diseases Antibodies  >3 publications with ACTN1 and Nervous System Diseases
 Urinary Bladder Neoplasms Antibodies  >2 publications with ACTN1 and Urinary Bladder Neoplasms
 Adenocarcinoma Antibodies  >2 publications with ACTN1 and Adenocarcinoma
 Nephritis Antibodies  >1 publications with ACTN1 and Nephritis
 Cardiovascular Diseases Antibodies  >1 publications with ACTN1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >1 publications with ACTN1 and Heart Diseases
 Lung Neoplasms Antibodies  >1 publications with ACTN1 and Lung Neoplasms
 Cell Transformation, Neoplastic Antibodies  >1 publications with ACTN1 and Cell Transformation, Neoplastic
 Inflammation Antibodies  >1 publications with ACTN1 and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >16 publications with ACTN1 and Muscle
 Blood Antibodies  >6 publications with ACTN1 and Blood
 Brain Antibodies  >6 publications with ACTN1 and Brain
 Prostate Antibodies  >3 publications with ACTN1 and Prostate
 Kidney Antibodies  >3 publications with ACTN1 and Kidney
 Lung Antibodies  >3 publications with ACTN1 and Lung
 Heart Antibodies  >3 publications with ACTN1 and Heart
 Embryonic Tissue Antibodies  >3 publications with ACTN1 and Embryonic Tissue
 Bladder Antibodies  >2 publications with ACTN1 and Bladder
 Nerve Antibodies  >2 publications with ACTN1 and Nerve
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