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anti-Orm1 antibody :: Rat anti-Mouse a1-Acid Glycoprotein Monoclonal Antibody

Scan QR to view Datasheet Catalog #    MBS609367
SDS-PAGE
Unit / Price
0.1 mg  /  $605 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

a1-Acid Glycoprotein (Orm1), Monoclonal Antibody

 Also Known As   

a1-Acid Glycoprotein (Alpha-1-acid Glycoprotein, AGP 1, AGP1, AGP-1, AGP-A, Alpha-1-AGP, Orosomucoid 1, Orosomucoid-1, OMD 1, OMD-1, ORM, ORM1)

 Product Synonym Names    Anti -a1-Acid Glycoprotein (Alpha-1-acid Glycoprotein, AGP 1, AGP1, AGP-1, AGP-A, Alpha-1-AGP, Orosomucoid 1, Orosomucoid-1, OMD 1, OMD-1, ORM, ORM1)
 Product Gene Name   

anti-Orm1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 5; NC_005104.2 (80325042..80328194). Location: 5q24
 3D Structure    ModBase 3D Structure for P02764
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 Clonality    Monoclonal
 Isotype    IgG1
 Clone Number    10K30
 Host    Rat
 Species Reactivity    Mouse
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 Specificity    Recognizes mouse AGP.
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.
 Concentration    ~0.5mg/ml (after reconsitution) (lot specific)
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 Immunogen    Mouse serum-derived AGP (AGP; Accession #Q60590). Species sequence homology: rat (70%), human (47%).
 Hybridoma    Fusion of a mouse myeloma with B cells obtained from a rat immunized with AGP purified from mouse serum.
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-Orm1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-Orm1 antibody

   a1-Acid Glycoprotein (AGP; also OMD/Orosomucoid) is a 40-46kD member of the immunocalin subfamily, lipocalin family of molecules. In mouse, circulating AGP is principally the product of hepatocytes that originates from multiple related genes (AGP-1, -2 and -3 in Mus musculus). Circulating AGP-1 and -2 are both 189aa in length, the principal sources of protein, and show 83% aa identity; AGP-3 contributes little to the AGP pool. In mouse blood, AGP is normally 200-400ug/ml. In response to inflammatory mediators (IL-6; IL-1), its concentration will rise 2-10 fold. More importantly, a complex glycosylation pattern will also change, transitioning from modestly branched to highly branched oligosaccharides. This change is reflected in its bioactivity, which has been shown to be a function of carbohydrate branching. AGP is generally considered to be a suppressor of inflammation. Rat and human AGP share only 70% and 47% aa identity with mouse AGP, respectively.
 Product Categories/Family for anti-Orm1 antibody    Antibodies; Abs to Carbohydrates, Glycoproteins
 Applications Tested/Suitable for anti-Orm1 antibody   

Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-Orm1 antibody    Dilution: Western Blot: 2ug/ml
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 SDS-PAGE of anti-Orm1 antibody    Lysates were prepared from mouse liver extract in reducing sample buffer, resolved by SDS-PAGE (30ug total protein/lane), and transferred to an Immobilon-P membrane. The blot was developed with 2ug/ml MBS609367 and chemiluminescent detection substrate.
anti-Orm1 antibody SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for Orm1. It may not necessarily be applicable to this product.
 NCBI GI #    16757980
 NCBI GeneID    24614
 NCBI Accession #    NP_445740.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_053288.1 [Other Products]
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 UniProt Primary Accession #    P02764 [Other Products]
 UniProt Related Accession #    P02764 [Other Products]
 Molecular Weight    23,575 Da [Similar Products]
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 NCBI Official Full Name    alpha-1-acid glycoprotein
 NCBI Official Synonym Full Names    orosomucoid 1
 NCBI Official Symbol    Orm1 [Similar Products]
 NCBI Official Synonym Symbols   
AGP; OMD; Orm; Agpa1
[Similar Products]
 NCBI Protein Information    alpha-1-acid glycoprotein
 UniProt Protein Name    Alpha-1-acid glycoprotein
 UniProt Synonym Protein Names   
Orosomucoid
 Protein Family    Alpha-1-acid glycoprotein
 UniProt Gene Name    Orm1 [Similar Products]
 UniProt Entry Name    A1AG_RAT
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 NCBI Summary for Orm1    an acute phase reactant protein; may have a role in the acute inflammation response [RGD]
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 UniProt Comments for Orm1    ORM1: Functions as transport protein in the blood stream. Binds various ligands in the interior of its beta-barrel domain. Also binds synthetic drugs and influences their distribution and availability in the body. Appears to function in modulating the activity of the immune system during the acute-phase reaction. Belongs to the calycin superfamily. Lipocalin family.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space

Molecular Function: drug binding

Biological Process: response to drug; organ regeneration; response to vitamin E; regulation of immune system process; transport; acute-phase response; response to lipopolysaccharide; response to organic cyclic substance; chronic inflammatory response to antigenic stimulus; acute inflammatory response to antigenic stimulus
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 Research Articles on Orm1    1. Surprisingly, AGP-over-expressing mice were not protected against renal ischemia-reperfusion injury.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-Orm1 antibodyOrgans/Tissues associated with anti-Orm1 antibody
 Disease Name  Pubmed Publications
 Skin Diseases Antibodies  >8 publications with Orm1 and Skin Diseases
 Inflammation Antibodies  >8 publications with Orm1 and Inflammation
 Neoplasms Antibodies  >6 publications with Orm1 and Neoplasms
 Lung Diseases Antibodies  >5 publications with Orm1 and Lung Diseases
 Acute-Phase Reaction Antibodies  >4 publications with Orm1 and Acute-Phase Reaction
 Asthma Antibodies  >3 publications with Orm1 and Asthma
 Respiratory Hypersensitivity Antibodies  >3 publications with Orm1 and Respiratory Hypersensitivity
 Breast Neoplasms Antibodies  >3 publications with Orm1 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >3 publications with Orm1 and Cardiovascular Diseases
 Psoriasis Antibodies  >3 publications with Orm1 and Psoriasis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >7 publications with Orm1 and Liver
 Placenta Antibodies  >1 publications with Orm1 and Placenta
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